|Name||Prof. Dr. Gisbert Schneider|
|Field||Computer-Assisted Drug Design|
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 411
|Telephone||+41 44 633 73 27|
|Fax||+41 44 633 13 79|
|Department||Chemistry and Applied Biosciences|
|535-0023-00L||Computer-Assisted Drug Design (Practical Course) |
Does not take place this semester.
Limited number of participants.
|4 credits||6P||G. Schneider|
|Abstract||The practical course is open for master and graduate students to get an introduction into hands-on computer-assisted drug design. The class includes an introduction to computer-based screening of a virtual compound library, subsequent synthesis of candidate ligands, and biochemically testing for activity on pharmacologically important drug targets.|
|Objective||Participants become familiar with state-of-the-art methodologies in a real-life computer-aided medicinal chemistry project. Participants work as small teams, perform literature research and discuss recent research findings. A seminar talk is to be given presenting the molecular design strategy chosen and the results obtained during the course.|
|Content||The course offers the possibility for people with and without computational and or laboratory background to get an introduction into computer-assisted drug design, as well as practical training in a modern chemical laboratory. Using various software suites, the participants will computationally create and screen a virtual compound library for potential active small molecules. The process will involve an introduction to screening a virtual compound library, synthesizing candidate inhibitors, and biophysical testing against a pharmacologically important drug target.|
|Lecture notes||Detailed information will be handed out during the course.|
Schneider, G. and Baringhaus, K.-H. (2008) Molecular Design - Concepts and Applications. Wiley-VCH, Weinheim, New York.
|Prerequisites / Notice||The class is organized as a two-week block course.|
The number of participants is limited.
Kick-off meeting and confirmation of registration (Vorbesprechung und Platzvergabe): During the last lecture of the class "Computer-Assisted Drug Design" (535-0022-00)
Ideally, students interested in the course participated and successfully passed the lecture "Computer-Assisted Drug Design" (535-0022-00).
|535-0024-00L||Methods in Drug Design |
Does not take place this semester.
Complementary to the practical course "Computer-Assisted Drug Design (Practical Course)" 535-0023-00L . Compulsory for the students of the practical course, open for other interested students.
|1 credit||1V||G. Schneider|
|Abstract||The lecture is organized as a two-week block during the practical course "Computer-Assisted Drug Design" (535-0023-00 P), totalling 10 two-hour lectures. It provides an introduction to advanced drug design techniques and approaches emphasizing computer-assisted molecular design.|
|Objective||Participants will learn about computational algorithms and advanced experimental approaches to drug discovery and design, including selected actual topics and practical applications. The contents of the lecture will allow for a deeper understanding of modern computer-assisted drug design methods and how they are linked to experimental applications. The main focus is on computational medicinal chemistry, so that participants will be able to use relevant computer-based methods in own research projects.|
|Literature||Schneider, G. and Baringhaus, K.-H. (2008) Molecular Design - Concepts and Applications. Wiley-VCH, Weinheim, New York.|
Additional selected literature will be provided during the lecture.
|Prerequisites / Notice||The lecture is mandatory for all participants of the course "Computer-Assisted Drug Design" (535-0023-00 P).|
|535-0900-00L||Seminars on Drug Discovery and Development||1 credit||1K||R. Schibli, K. Eyer, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer|
|Abstract||State-of-the-art information on drug discovery and development by experts from academia and industry.|
|Objective||State-of-the-art information on drug discovery and development.|
|Content||Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics.|
|535-2000-00L||Seminar for Group Members||0 credits||2S||G. Schneider|
|Abstract||Weekly group seminar, in which members of the research team present and discuss the results of their projects and selected reports from the current scientific literature.|
|Objective||Participants learn to present scientific studies and discuss own results in greater context.|