Jeffrey W. Bode: Catalogue data in Autumn Semester 2022

Name Prof. Dr. Jeffrey W. Bode
FieldSynthetic Organic Chemistry
Address
Lab. für Organische Chemie
ETH Zürich, HCI F 315
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 21 03
E-mailbode@org.chem.ethz.ch
DepartmentChemistry and Applied Biosciences
RelationshipFull Professor

NumberTitleECTSHoursLecturers
529-0016-00LBCB III: Organic Chemistry Restricted registration - show details 8 credits12PJ. W. Bode
AbstractLaboratory course in Organic Chemistry for students of "Biochemisty - Chemical Biology"
ObjectiveIntroduction into basic techniques used in the organic laboratory. Understanding organic reactions through experiments.
ContentPart I: Basic operations such as the isolation, purification, and characterization of organic compounds: distillation, extraction, chromatography, crystallization, IR (UV/1H-NMR)-spectroscopy for the identification of the constitution of organic compounds.

Part II: Organic reactions: preparative chemistry. From simple, one-step to multi-step syntheses. The syntheses include classic Organic Chemistry as well as methods widely used in a Chemical Biology context.
Lecture notessee https://bode.ethz.ch/education/bcb-iii/bcb-iii-lab-course.html
LiteratureR. K. Müller, R. Keese: "Grundoperationen der präparativen organischen Chemie"; J. Leonard, B. Lygo, G. Procter: "Praxis der Organischen Chemie" (Übersetzung herausgegeben von G. Dyker), VCH, Weinheim, 1996, ISBN 3-527-29411-2
Prerequisites / NoticeBasisprüfung + BCB I: General Chemistry
CompetenciesCompetencies
Subject-specific CompetenciesConcepts and Theoriesassessed
Techniques and Technologiesassessed
Method-specific CompetenciesAnalytical Competenciesassessed
Decision-makingassessed
Media and Digital Technologiesfostered
Problem-solvingassessed
Project Managementfostered
Social CompetenciesCommunicationfostered
Cooperation and Teamworkfostered
Customer Orientationfostered
Leadership and Responsibilityfostered
Self-presentation and Social Influence fostered
Sensitivity to Diversityfostered
Negotiationfostered
Personal CompetenciesAdaptability and Flexibilityfostered
Creative Thinkingfostered
Critical Thinkingfostered
Integrity and Work Ethicsfostered
Self-awareness and Self-reflection fostered
Self-direction and Self-management fostered
529-0018-00LOrganic Chemistry for Biochemistry and Chemical Biology6 credits3GJ. W. Bode
AbstractThe synthesis and reactivity of organic molecules plays a crucial role in chemical biology, particularly for the interrogation of biological pathways and phenomena. This course will cover advanced topics in the design and synthesis of organic molecules for applications in biochemistry and chemical biology, with particular emphasis on the mechanistic understanding of these reactions and processes.
ObjectiveAfter the completion of this lecture, the students will have an understanding of organic chemistry commonly employed in the field of chemical biology, be able to apply these concepts to the design and synthesis of tools for probing biological pathways, and explain the underlying reaction mechanisms of selective reactions.
ContentThe course will discuss past and recent advances in the synthesis of biomolecules, organic chemistry for applications in chemical biology, and the mechanism of relevant reactions. Topics will include chemical ligations, bioorthoganal reactions, photoaffinity probes, photopharmacology, activity based probes, targeted protein degraders, chemical probes for metabolites, fluorescent dyes and imaging, caged biomolecules, conditional activation, site-specific protein modification, and metabolic engineering.
Lecture notesLecture notes and other material relevant for the course will be available online under https://bode.ethz.ch/education.html.
LiteratureRelevant research articles and review papers will be available in the course and course material.
Prerequisites / NoticeThis is an advanced organic chemistry course. Prior knowledge of organic synthesis, reactions, and mechanisms is required. Familiarity with biochemistry and biology is recommended.
CompetenciesCompetencies
Subject-specific CompetenciesConcepts and Theoriesassessed
Techniques and Technologiesassessed
Method-specific CompetenciesAnalytical Competenciesfostered
Decision-makingfostered
Media and Digital Technologiesfostered
Problem-solvingassessed
Project Managementfostered
Social CompetenciesCommunicationassessed
Cooperation and Teamworkassessed
Customer Orientationfostered
Leadership and Responsibilityfostered
Self-presentation and Social Influence fostered
Sensitivity to Diversityfostered
Negotiationfostered
Personal CompetenciesAdaptability and Flexibilityassessed
Creative Thinkingassessed
Critical Thinkingassessed
Integrity and Work Ethicsfostered
Self-awareness and Self-reflection fostered
Self-direction and Self-management fostered
529-0241-10LSelectivity in Organic Synthesis6 credits3GJ. W. Bode
AbstractFundamentals of selective organic reactions, including current and historical examples of enantioselectivity, regioselectivity, chemoselectivity. Further aspects include recent developments in catalysis, strategies and tools for selective organic synthesis.
ObjectiveUnderstanding and explaining the origin of selectivity in organic synthesis and the application of selective organic reactions to the construction of complex organic and biological molecules.
ContentFundamental concepts and recent advances for the selective synthesis of complex organic molecules, including natural products, pharmaceuticals, and biological molecules. Key concepts include the development of enantioselective and regioselective catalysts, the identification of new reaction mechanisms and pathways, and technological advances for facilitating the synthesis of organic molecules. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized.
Lecture noteswill be provided in class and online
LiteratureSuggesting Textbooks

Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006.
CompetenciesCompetencies
Subject-specific CompetenciesConcepts and Theoriesassessed
Method-specific CompetenciesAnalytical Competenciesassessed
Media and Digital Technologiesfostered
Problem-solvingassessed
Project Managementfostered
Social CompetenciesCommunicationassessed
Cooperation and Teamworkfostered
Customer Orientationfostered
Leadership and Responsibilityfostered
Self-presentation and Social Influence fostered
Sensitivity to Diversityfostered
Negotiationfostered
Personal CompetenciesAdaptability and Flexibilityassessed
Creative Thinkingassessed
Critical Thinkingassessed
Integrity and Work Ethicsfostered
529-0290-00LOrganic Chemistry (Seminar) Restricted registration - show details 0 credits2SE. M. Carreira, J. W. Bode, H. Wennemers, R. Zenobi
Abstract
Objective
529-0299-00LOrganic Chemistry0 credits1.5KJ. W. Bode, E. M. Carreira, P. Chen, H. Wennemers, R. Zenobi
Abstract
Objective