Jeffrey W. Bode: Katalogdaten im Herbstsemester 2022 |
| Name | Herr Prof. Dr. Jeffrey W. Bode |
| Lehrgebiet | Synthetische Organische Chemie |
| Adresse | Lab. für Organische Chemie ETH Zürich, HCI F 315 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telefon | +41 44 633 21 03 |
| bode@org.chem.ethz.ch | |
| Departement | Chemie und Angewandte Biowissenschaften |
| Beziehung | Ordentlicher Professor |
| Nummer | Titel | ECTS | Umfang | Dozierende | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0016-00L | BCB III: Organische Chemie  | 8 KP | 12P | J. W. Bode | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Laborpraktikum in Organischer Chemie für den Studiengang "Biochemie - Chemische Biologie" | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Einführung in grundlegende Arbeitstechniken der Organischen Chemie. Verständnis organischer Reaktionen durch experimentelles Arbeiten. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Teil I: Grundlegende Arbeitsmethoden wie Isolation, Reinigung und Charakterisierung organischer Substanzen: Distillation Extraktion, Chromatographie, Kristallisation, IR (UV/1H-NMR)-Spektroskopie zur Identifizierung der Zusammensetzung organischer Substanzen. Teil II: Organische Reaktionen: Präparative Chemie. Von einfachen, Einstufen- zu Mehrstufensynthesen. Die Synthesen umfassen ebenso klassische Organische Chemie, als auch Methoden, die im Feld der Chemischen Biologie breite Anwendung finden. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | siehe https://bode.ethz.ch/education/bcb-iii/bcb-iii-lab-course.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | R. K. Müller, R. Keese: "Grundoperationen der präparativen organischen Chemie"; J. Leonard, B. Lygo, G. Procter: "Praxis der Organischen Chemie" (Übersetzung herausgegeben von G. Dyker), VCH, Weinheim, 1996, ISBN 3-527-29411-2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Basisprüfung + BCB I: Allgemeine Chemie | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kompetenzen |
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| 529-0018-00L | Organic Chemistry for Biochemistry and Chemical Biology | 6 KP | 3G | J. W. Bode | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The synthesis and reactivity of organic molecules plays a crucial role in chemical biology, particularly for the interrogation of biological pathways and phenomena. This course will cover advanced topics in the design and synthesis of organic molecules for applications in biochemistry and chemical biology, with particular emphasis on the mechanistic understanding of these reactions and processes. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | After the completion of this lecture, the students will have an understanding of organic chemistry commonly employed in the field of chemical biology, be able to apply these concepts to the design and synthesis of tools for probing biological pathways, and explain the underlying reaction mechanisms of selective reactions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | The course will discuss past and recent advances in the synthesis of biomolecules, organic chemistry for applications in chemical biology, and the mechanism of relevant reactions. Topics will include chemical ligations, bioorthoganal reactions, photoaffinity probes, photopharmacology, activity based probes, targeted protein degraders, chemical probes for metabolites, fluorescent dyes and imaging, caged biomolecules, conditional activation, site-specific protein modification, and metabolic engineering. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Lecture notes and other material relevant for the course will be available online under https://bode.ethz.ch/education.html. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Relevant research articles and review papers will be available in the course and course material. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | This is an advanced organic chemistry course. Prior knowledge of organic synthesis, reactions, and mechanisms is required. Familiarity with biochemistry and biology is recommended. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 529-0241-10L | Selectivity in Organic Synthesis | 6 KP | 3G | J. W. Bode | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Fundamentals of selective organic reactions, including current and historical examples of enantioselectivity, regioselectivity, chemoselectivity. Further aspects include recent developments in catalysis, strategies and tools for selective organic synthesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Understanding and explaining the origin of selectivity in organic synthesis and the application of selective organic reactions to the construction of complex organic and biological molecules. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Fundamental concepts and recent advances for the selective synthesis of complex organic molecules, including natural products, pharmaceuticals, and biological molecules. Key concepts include the development of enantioselective and regioselective catalysts, the identification of new reaction mechanisms and pathways, and technological advances for facilitating the synthesis of organic molecules. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | will be provided in class and online | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Suggesting Textbooks Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 529-0290-00L | Organic Chemistry (Seminar) | 0 KP | 2S | E. M. Carreira, J. W. Bode, H. Wennemers, R. Zenobi | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0299-00L | Organic Chemistry | 0 KP | 1.5K | J. W. Bode, E. M. Carreira, P. Chen, H. Wennemers, R. Zenobi | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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