Antonio Lanzavecchia: Catalogue data in Autumn Semester 2018

Name Prof. em. Dr. Antonio Lanzavecchia
Address
Institut für Mikrobiologie
ETH Zürich, HCI F 417
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
E-maillanzavecchia@micro.biol.ethz.ch
DepartmentBiology
RelationshipProfessor emeritus

NumberTitleECTSHoursLecturers
551-0223-00LImmunology III4 credits2VM. Kopf, M. Bachmann, S. B. Freigang, J. Kisielow, A. Lanzavecchia, S. R. Leibundgut, A. Oxenius, R. Spörri, L. Tortola
AbstractThis course provides a detailed understanding of
- development of T and B cells
- the dynamics of a immune response during acute and chronic infection
- mechanisms of immunopathology
- modern vaccination strategies
Key experimental results will be shown to help understanding how immunological text book knowledge has evolved.
ObjectiveObtain a detailed understanding of
- the development, activation, and differentiation of different types of T cells and their effectormechanisms during immune responses,
- Recognition of pathogenic microorganisms by the host cells and molecular events thereafter,
- events and signals for maturation of naive B cells to antibody producing plasma cells and memory B cells.
- Optimization of B cell responses by intelligent design of new vaccines
Contento Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg)
o NK T cells and responses to lipid antigens
o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17
o Overview of cytokines and their effector function
o Co-stimulation (signals 1-3)
o Dendritic cells
o Evolution of the "Danger" concept
o Cells expressing Pattern Recognition Receptors and their downstream signals
o T cell function and dysfunction in acute and chronic viral infections
LiteratureDocuments of the lectures are available for download at:
https://moodle-app2.let.ethz.ch/course/view.php?id=2581&notifyeditingon=1
Prerequisites / NoticeImmunology I and II recommended but not compulsory