Name | Prof. Dr. Mustafa Hani Khammash |
Field | Control Theory and Systems Biology |
Address | Regelungstheorie u. Systembiologie ETH Zürich, BSS J 13.2 Klingelbergstrasse 48 4056 Basel SWITZERLAND |
Telephone | +41 61 387 33 56 |
mustafa.khammash@bsse.ethz.ch | |
URL | http://www.bsse.ethz.ch/ctsb |
Department | Biosystems Science and Engineering |
Relationship | Full Professor |
Number | Title | ECTS | Hours | Lecturers | |
---|---|---|---|---|---|
636-0016-00L | Computational Systems Biology: Stochastic Approaches ![]() | 4 credits | 3G | M. H. Khammash, A. Gupta | |
Abstract | This course is concerned with the development of computational methods for modeling, simulation, and analysis of stochasticity in living cells. Using these tools, the course explores the richness of stochastic phenomena, how it arises from the interactions of dynamics and noise, and its biological implications. | ||||
Learning objective | To understand the origins and implications of stochastic noise in living cells, and to learn the computational tools for the modeling, simulation, analysis, and identification of stochastic biochemical reaction networks. | ||||
Content | The cellular environment is abuzz with noise. A key source of this noise is the randomness that characterizes the motion of cellular constituents at the molecular level. Cellular noise not only results in random fluctuations (over time) within individual cells, but it is also a main source of phenotypic variability among clonal cell populations. Review of basic probability and stochastic processes; Introduction to stochastic gene expression; deterministic vs. stochastic models; the stochastic chemical kinetics framework; a rigorous derivation of the chemical master equation; moment computations; linear vs. nonlinear propensities; linear noise approximations; Monte Carlo simulations; Gillespie's Stochastic Simulation Algorithm (SSA) and variants; direct methods for the solution of the Chemical Master Equation; moment closure methods; intrinsic and extrinsic noise in gene expression; parameter identification from noise; propagation of noise in cell networks; noise suppression in cells; the role of feedback; exploiting noise; bimodality and stochastic switches. | ||||
Literature | Literature will be distributed during the course as needed. | ||||
Prerequisites / Notice | Students are expected to have completed the course `Mathematical modeling for systems biology (BSc Biotechnology) or `Computational systems biology (MSc Computational biology and bioinformatics). Concurrent enrollment in `Computational Systems Biology: Deterministic Approaches is recommended. | ||||
636-0301-00L | Current Topics in Biosystems Science and Engineering | 2 credits | 1S | T. Stadler, N. Beerenwinkel, Y. Benenson, K. M. Borgwardt, P. S. Dittrich, M. Fussenegger, A. Hierlemann, D. Iber, M. H. Khammash, D. J. Müller, S. Panke, R. Paro, R. Platt, S. Reddy, T. Schroeder, J. Stelling | |
Abstract | This seminar will feature invited lectures about recent advances and developments in systems biology, including topics from biology, bioengineering, and computational biology. | ||||
Learning objective | To provide an overview of current systems biology research. | ||||
Content | The final list of topics will be available at http://www.bsse.ethz.ch/education/. |