Jan Kisielow: Catalogue data in Autumn Semester 2021 |
| Name | Dr. Jan Kisielow |
| Address | Inst. f. Molecular Health Sciences ETH Zürich, HPL G 14.2 Otto-Stern-Weg 7 8093 Zürich SWITZERLAND |
| jan.kisielow@biol.ethz.ch | |
| Department | Environmental Systems Science |
| Relationship | Lecturer |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||
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| 551-0223-00L | Immunology III | 4 credits | 2V | M. Kopf, S. B. Freigang, J. Kisielow, S. R. Leibundgut, A. Oxenius, C. Schneider, E. Slack, R. Spörri, L. Tortola | ||||||||||||||||||||||||||
| Abstract | This course provides a detailed understanding of - development of T and B cells - the dynamics of a immune response during acute and chronic infection - mechanisms of immunopathology - modern vaccination strategies Key experimental results will be shown to help understanding how immunological text book knowledge has evolved. | |||||||||||||||||||||||||||||
| Learning objective | Obtain a detailed understanding of - the development, activation, and differentiation of different types of T cells and their effectormechanisms during immune responses, - Recognition of pathogenic microorganisms by the host cells and molecular events thereafter, - events and signals for maturation of naive B cells to antibody producing plasma cells and memory B cells. - Optimization of B cell responses by intelligent design of new vaccines | |||||||||||||||||||||||||||||
| Content | o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg) o NK T cells and responses to lipid antigens o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17 o Overview of cytokines and their effector function o Co-stimulation (signals 1-3) o Dendritic cells o Evolution of the "Danger" concept o Cells expressing Pattern Recognition Receptors and their downstream signals o T cell function and dysfunction in acute and chronic viral infections | |||||||||||||||||||||||||||||
| Literature | Documents of the lectures are available for download at: https://moodle-app2.let.ethz.ch/course/view.php?id=2581¬ifyeditingon=1 | |||||||||||||||||||||||||||||
| Prerequisites / Notice | Immunology I and II recommended but not compulsory | |||||||||||||||||||||||||||||
| 551-1171-00L | Immunology: From Milestones to Current Topics | 4 credits | 2S | B. Ludewig, J. Kisielow, A. Oxenius, L. Tortola, University lecturers | ||||||||||||||||||||||||||
| Abstract | Milestones in Immunology: on old concepts and modern experiments | |||||||||||||||||||||||||||||
| Learning objective | The course will cover the current grand topics in immunology: B cells, innate immunity, antigen presentation, tumor immunity, T cells, myeloid cells and stromal cells. For each topic two or four hours will be allocated. Historical milestone papers will be presented by the tutor/lecturer providing an overview on the development of the theoretical framework and critical technological advances. The students will read the historical milestone papers and contribute to the discussion. In the second part of the lecture, students will present recent high impact research papers that have emerged from the landmark achievements of the previously discussed milestone concepts. | |||||||||||||||||||||||||||||
| Content | Milestones and current topics of innate immunity, antigen presentatino, B cells, thymus and T cells, cytotoxic T cells, NK cells, stromal cells, CNS immunity and tumor immunology. | |||||||||||||||||||||||||||||
| Lecture notes | Original and review articles will be distributed by the respective lecturer. | |||||||||||||||||||||||||||||
| Literature | Literaturunterlagen werden vor Beginn des Kurses auf folgender website zugänglich sein: https://moodle-app2.let.ethz.ch/course/view.php?id=15568 | |||||||||||||||||||||||||||||
Competencies |
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