Jan Kisielow: Catalogue data in Autumn Semester 2020

Name Dr. Jan Kisielow
Inst. f. Molecular Health Sciences
ETH Zürich, HPL G 14.2
Otto-Stern-Weg 7
8093 Zürich
DepartmentEnvironmental Systems Science

551-0223-00LImmunology III4 credits2VM. Kopf, S. B. Freigang, J. Kisielow, S. R. Leibundgut, A. Oxenius, C. Schneider, E. Slack, R. Spörri, L. Tortola
AbstractThis course provides a detailed understanding of
- development of T and B cells
- the dynamics of a immune response during acute and chronic infection
- mechanisms of immunopathology
- modern vaccination strategies
Key experimental results will be shown to help understanding how immunological text book knowledge has evolved.
ObjectiveObtain a detailed understanding of
- the development, activation, and differentiation of different types of T cells and their effectormechanisms during immune responses,
- Recognition of pathogenic microorganisms by the host cells and molecular events thereafter,
- events and signals for maturation of naive B cells to antibody producing plasma cells and memory B cells.
- Optimization of B cell responses by intelligent design of new vaccines
Contento Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg)
o NK T cells and responses to lipid antigens
o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17
o Overview of cytokines and their effector function
o Co-stimulation (signals 1-3)
o Dendritic cells
o Evolution of the "Danger" concept
o Cells expressing Pattern Recognition Receptors and their downstream signals
o T cell function and dysfunction in acute and chronic viral infections
LiteratureDocuments of the lectures are available for download at:
Prerequisites / NoticeImmunology I and II recommended but not compulsory
551-1171-00LImmunology: from Milestones to Current Topics4 credits2SB. Ludewig, N. C. Joller, J. Kisielow, C. Münz, A. Oxenius, L. Tortola, M. van den Broek
AbstractImmunology: from Milestones to Current Topics 2020
ObjectiveThe course will cover the current grand topics in immunology: B cells, innate immunity, antigen presentation, tumor immunity, T cells, myeloid cells and stromal cells. For each topic two or four hours will be allocated. Historical milestone papers will be presented by the tutor/lecturer providing an overview on the development of the theoretical framework and critical technological advances. The students will read the historical milestone papers and contribute to the discussion. In the second part of the lecture, students will present recent high impact research papers that have emerged from the landmark achievements of the previously discussed milestone concepts.
ContentMilestones and current grand topics in immunology: B cells, innate immunity, antigen presentation, tumor immunity, T cells, myeloid cells and stromal cells.
Lecture notesOriginal and review articles will be distributed by the lecturer.
LiteratureLiteraturunterlagen werden vor Beginn des Kurses auf folgender website zugänglich sein: Moodle Course https://moodle-app2.let.ethz.ch/course/view.php?id=13066