Christian Wolfrum: Catalogue data in Autumn Semester 2023

Name	Prof. Dr. Christian Wolfrum
Field	Translational Nutrition Biology
Address	VP Forschung ETH Zürich, HG F 57 Rämistrasse 101 8092 Zürich SWITZERLAND
Telephone	+41 44 632 20 39
E-mail	christian-wolfrum@ethz.ch
Department	Health Sciences and Technology
Relationship	Full Professor and Vice President of Research

Number

Title

ECTS

Hours

Lecturers

377-0101-00L

Fundamentals of Medicine and the Human Body

2 credits

J. Goldhahn, R.‑A. Kubik, J. Loffing, C. Wolfrum

Abstract

Fundamental principles of human medicine, Basic Life Support (BLS) and introduction to histology and microscopy.

Learning objective

After completion of the course, the students:
- have a basic understanding of elementary building blocks and processes as a basis for human medicine, e.g. cell structure and cycle.
- know basic terminology of anatomy.
- understand the process of medical care from first aid to rehabilitation.
- understand the advantages and disadvantages of emergency diagnostics, especially ultrasound.
- know the basics of microscopy and histology.
- have learned the basics of Basic Life Support:
- recognize the symptoms of cardiovascular arrest.
- alarm in an emergency according to the situation.
- If available, they organize an AED and use it correctly and as quickly as possible.
- perform sufficient chest compressions on the phantom.
- perform effective ventilation on the phantom using a pocket mask.
- will identify possible ventilation complications. Under certain circumstances, they will not attempt further ventilation.
- will identify the limits of cardiopulmonary resuscitation.
- under stress, they do not risk their own or other "helpers'" lives.

Content

Based on a complex clinical case, students are familiarized with the course of medical care from initial treatment to rehabilitation. Basic terms, modules and processes are introduced. In addition, the students experience the basics of imaging techniques, especially ultrasound.
The students complete the Basic Life Support course. After this training sequence, all participants should be able to initiate resuscitation measures in private and in-hospital settings.
The students experience learning, teaching and working in the hospital sector as a social process and teamwork in which all senses and a wide range of skills are needed.
In addition, the students experience in three workshops the basic process of a physiotherapeutic intervention with the concepts of clinical reasoning, therapeutic aspects and therapy progression.
An intensive course in microscopy/histology enables students to perform microscopy independently and to understand histological sections of a histological sample, but also online.

377-0301-03L

Endocrinology, Metabolism

5 credits

M. Stoffel, F. Beuschlein, A. Hall, C. Wolfrum

Abstract

Discussion of normal structure and function of the endocrine systems, their interaction with the autonomic nervous system and their role in metabolism. In addition, pathophysiological and clinical aspects, diagnostics and therapeutic concepts of the most important endocrine diseases and related metabolic disorders as well as respective preventive measures are adressed.

Learning objective

Upon successful completion of this module, students should:

- be able to explain the systematics of the endocrine system;
- know the structure and function of the hypothalamus, pituitary gland, adrenal gland, endocrine pancreas, thyroid gland, ovaries, testes;
- know the principles and regulation of bone, calcium and phosphate metabolism, energy balance, glucose metabolism, lipid metabolism, blood pressure;
- know the hormonally regulated metabolic processes (carbohydrates, protein and fat);
- know the most important endocrine diseases and tumors, their development, clinic, diagnostics and therapy;
- know the most important measures for the prevention of metabolic diseases and the underlying mechanisms.

Content

In this module, students learn about anatomy, physiology, and pathophysiology of the endocrine glands, as well as the clinical, diagnostic, therapeutic, and preventive aspects of the most important endocrine diseases. This includes:
- Systematics of the endocrine system: structure and anatomical location of the various endocrine glands.
- Neuronal innervation and vascular supply area of the endocrine glands.
- Hormone classes: Protein and polypeptide hormones, amino and amino acid derivatives steroid hormones, biosynthesis of protein and polypeptide hormones, biosynthesis of amino and amino acid derivatives, biosynthesis of steroid hormones, storage of hormones, secretion of hormones, transport of hormones, half-lives, degradation and excretion of hormones.
- Transmission of information by hormones: hormone action at receptors, structure and function of membrane-associated hormone receptors, structure and function of nuclear receptors, regulation of hormone secretion.
- Structure and function of the hypothalamus, structure and function of the pituitary gland.
- Structure and function of the thyroid gland, under- and over-functioning of the thyroid gland, principles of diagnostics and therapy of thyroid diseases. Symptoms, medical history and clinical examination of thyroid diseases,
- Bones, calcium and phosphate metabolism.
- Regulation of glucose, lipid and protein metabolism, eating disorders, etiology, diagnostics, therapy and prevention of adpositas.
- Structure and function of endocrine pancreas, pathogenesis of different types of diabetes mellitus. Principles of diagnostics and therapy and prevention of type 1 and type 2 diabetes, risk factors and complications. Symptoms, medical history and clinical examination in diabetes mellitus,
- Structure and function of the adrenal gland, pathogenesis, principles of diagnostics and therapy of diseases with hyper- and hypofunction of the adrenal gland. Symptoms, anamnesis and clinical examination in case of hyper- and hypofunction of the adrenal gland.
- Structure and function of the ovaries and testis, principles of reproductive physiology.

Lecture notes

There is no traditional script for this course. Instead the course is supported by a Moodle page through which students have access to all necessary texts, exercises, videos and activities.

Literature

The essential course material will be available on the course's Moodle Page in the form of scripts and lesson handouts.
The course does not have an "official" textbook, but students may find a general reference book on the topic interesting. For this purpose the text "Endokrinologie und Stoffwechsel” von Stefan Fischli und Giatgen A. Spinas (Herausgeber), Thieme Verlag, may be helpful.

Prerequisites / Notice

The course builds on the content of the "Chemie für Mediziner", "Biochemie", “Pathobiochemie”, "Pharmakologie für Mediziner" and "Molekulare Genetik und Zellbiologie" course and “Nutrition and Digestion”.

395-0103-00L

Precision Medicine

3 credits

S. Modica, A. Ghosh, C. Wolfrum

Abstract

Precision Medicine is a new approach in health care aiming to deliver personalized prevention and treatment for human diseases, by taking into account individual differences in lifestyle, environment, and biology.

Learning objective

After taking this course, participants will be able

- to describe the goal of precision medicine;
- to explain different next-generation sequencing technologies;
- to illustrate how to make good use of public biological/clinical repositories;
- to demonstrate basic concepts of big data and machine learning;
- to explain how to genotype biological samples for a genetic disease;
- to describe examples of complicated ethical or clinical situations in personalized medicine.

752-6001-00L

Introduction to Nutritional Science

3 credits

N. Stoffel, C. Wolfrum

Abstract

This course introduces basic concepts of micro- and macronutrient nutrition. Micronutrients studied include fat-soluble and water-soluble vitamins, minerals and trace elements. Macronutrients include proteins, fat and carbohydrates. Special attention is given to nutrient digestion, bioavailability, metabolism and excretion with some focus on energy metabolism.

Learning objective

To introduce the students to the both macro- and micronutrients in relation to food and metabolism.

Content

The course is devided into two parts: Micronutrients and macronutrients. The micronutrient part includes fat-soluble vitamins, water-soluble vitamins, minerals and trace elements. The macronutrient part introduces basic nutritional aspects of proteins, fats, carbohydrates and energy metabolism. The nutrients are described in relation to digestion, absorption and metabolism. Special aspects of homeostasis and homeorhesis are emphasized.

Lecture notes

There is no script. Powerpoint presentations will be made available.

Literature

Elmadfa I & Leitzmann C: Ernährung des Menschen
UTB Ulmer, Stuttgart, 4. überarb. Ausgabe 2004
ISBN-10: 3825280365; ISBN-13: 978-3825280369

Garrow JS and James WPT: Human Nutrition and Dietetics
Churchill Livingstone, Edinburgh, 11th rev. ed. 2005
ISBN-10: 0443056277; ISBN-13: 978-0443056277

Competencies

Subject-specific Competencies

Concepts and Theories

fostered

752-6003-00L

Introduction to Nutritional Science

2 credits

1.5V

N. Stoffel, C. Wolfrum

Abstract

Learning objective

To introduce the students to the both the macro- and the micronutrients.

Content

Lecture notes

There is no script. Powerpoint presentations will be made available.

Literature

Competencies

Subject-specific Competencies

Concepts and Theories

fostered