Christian Wolfrum: Catalogue data in Autumn Semester 2022

Name Prof. Dr. Christian Wolfrum
FieldTranslational Nutrition Biology
Address
VP Forschung
ETH Zürich, HG F 57
Rämistrasse 101
8092 Zürich
SWITZERLAND
Telephone+41 44 632 20 39
E-mailchristian-wolfrum@ethz.ch
DepartmentHealth Sciences and Technology
RelationshipFull Professor and Vice President of Research

NumberTitleECTSHoursLecturers
376-0300-00LTranslational Science for Health and Medicine Restricted registration - show details 3 credits2GJ. Goldhahn, C. Wolfrum
AbstractTranslational science is a cross disciplinary scientific research that is motivated by the need for practical applications that help people. The course should help to clarify basics of translational science, illustrate successful applications and should enable students to integrate key features into their future projects.
Learning objectiveAfter completing this course, students will be able to understand:
Principles of translational science (including project planning, ethics application, basics of resource management and interdisciplinary communication)
ContentWhat is translational science and what is it not?
How to identify need?
- Disease concepts and consequences for research
- Basics about incidence, prevalence etc., and orphan indications
How to choose the appropriate research type and methodology
- Ethical considerations including ethics application
- Pros and cons of different types of research
- Coordination of complex approaches incl. timing and resources
How to measure success?
- Outcome variables
- Improving the translational process
Challenges of communication?
How independent is translational science?
- Academic boundary conditions vs. industrial influences
Positive and negative examples will be illustrated by distinguished guest speakers.
377-0101-00LFundamentals of Medicine and the Human Body Restricted registration - show details
Only for Human Medicine BSc
2 credits3GJ. Goldhahn, G. Csúcs, R.‑A. Kubik, C. Wolfrum
AbstractFundamental principles of human medicine, Basic Life Support (BLS) and introduction to histology and microscopy.
Learning objectiveAfter completion of the course, the students:
- have a basic understanding of elementary building blocks and processes as a basis for human medicine, e.g. cell structure and cycle.
- know basic terminology of anatomy.
- understand the process of medical care from first aid to rehabilitation.
- understand the advantages and disadvantages of emergency diagnostics, especially ultrasound.
- know the basics of microscopy and histology.
- have learned the basics of Basic Life Support:
- recognize the symptoms of cardiovascular arrest.
- alarm in an emergency according to the situation.
- If available, they organize an AED and use it correctly and as quickly as possible.
- perform sufficient chest compressions on the phantom.
- perform effective ventilation on the phantom using a pocket mask.
- will identify possible ventilation complications. Under certain circumstances, they will not attempt further ventilation.
- will identify the limits of cardiopulmonary resuscitation.
- under stress, they do not risk their own or other "helpers'" lives.
ContentBased on a complex clinical case, students are familiarized with the course of medical care from initial treatment to rehabilitation. Basic terms, modules and processes are introduced. In addition, the students experience the basics of imaging techniques, especially ultrasound.
The students complete the Basic Life Support course. After this training sequence, all participants should be able to initiate resuscitation measures in private and in-hospital settings.
The students experience learning, teaching and working in the hospital sector as a social process and teamwork in which all senses and a wide range of skills are needed.
In addition, the students experience in three workshops the basic process of a physiotherapeutic intervention with the concepts of clinical reasoning, therapeutic aspects and therapy progression.
An intensive course in microscopy/histology enables students to perform microscopy independently and to understand histological sections of a histological sample, but also online.
377-0301-03LEndocrinology, Metabolism Restricted registration - show details
Only for Human Medicine BSc
5 credits5VM. Stoffel, F. Beuschlein, A. Hall, C. Wolfrum
AbstractDiscussion of normal structure and function of the endocrine systems, their interaction with the autonomic nervous system and their role in metabolism. In addition, pathophysiological and clinical aspects, diagnostics and therapeutic concepts of the most important endocrine diseases and related metabolic disorders as well as respective preventive measures are adressed.
Learning objectiveUpon successful completion of this module, students should:

- be able to explain the systematics of the endocrine system;
- know the structure and function of the hypothalamus, pituitary gland, adrenal gland, endocrine pancreas, thyroid gland, ovaries, testes;
- know the principles and regulation of bone, calcium and phosphate metabolism, energy balance, glucose metabolism, lipid metabolism, blood pressure;
- know the hormonally regulated metabolic processes (carbohydrates, protein and fat);
- know the most important endocrine diseases and tumors, their development, clinic, diagnostics and therapy;
- know the most important measures for the prevention of metabolic diseases and the underlying mechanisms.
ContentIn this module, students learn about anatomy, physiology, and pathophysiology of the endocrine glands, as well as the clinical, diagnostic, therapeutic, and preventive aspects of the most important endocrine diseases. This includes:
- Systematics of the endocrine system: structure and anatomical location of the various endocrine glands.
- Neuronal innervation and vascular supply area of the endocrine glands.
- Hormone classes: Protein and polypeptide hormones, amino and amino acid derivatives steroid hormones, biosynthesis of protein and polypeptide hormones, biosynthesis of amino and amino acid derivatives, biosynthesis of steroid hormones, storage of hormones, secretion of hormones, transport of hormones, half-lives, degradation and excretion of hormones.
- Transmission of information by hormones: hormone action at receptors, structure and function of membrane-associated hormone receptors, structure and function of nuclear receptors, regulation of hormone secretion.
- Structure and function of the hypothalamus, structure and function of the pituitary gland.
- Structure and function of the thyroid gland, under- and over-functioning of the thyroid gland, principles of diagnostics and therapy of thyroid diseases. Symptoms, medical history and clinical examination of thyroid diseases,
- Bones, calcium and phosphate metabolism.
- Regulation of glucose, lipid and protein metabolism, eating disorders, etiology, diagnostics, therapy and prevention of adpositas.
- Structure and function of endocrine pancreas, pathogenesis of different types of diabetes mellitus. Principles of diagnostics and therapy and prevention of type 1 and type 2 diabetes, risk factors and complications. Symptoms, medical history and clinical examination in diabetes mellitus,
- Structure and function of the adrenal gland, pathogenesis, principles of diagnostics and therapy of diseases with hyper- and hypofunction of the adrenal gland. Symptoms, anamnesis and clinical examination in case of hyper- and hypofunction of the adrenal gland.
- Structure and function of the ovaries and testis, principles of reproductive physiology.
Lecture notesThere is no traditional script for this course. Instead the course is supported by a Moodle page through which students have access to all necessary texts, exercises, videos and activities.
LiteratureThe essential course material will be available on the course's Moodle Page in the form of scripts and lesson handouts.
The course does not have an "official" textbook, but students may find a general reference book on the topic interesting. For this purpose the text "Endokrinologie und Stoffwechsel” von Stefan Fischli und Giatgen A. Spinas (Herausgeber), Thieme Verlag, may be helpful.
Prerequisites / NoticeThe course builds on the content of the "Chemie für Mediziner", "Biochemie", “Pathobiochemie”, "Pharmakologie für Mediziner" and "Molekulare Genetik und Zellbiologie" course and “Nutrition and Digestion”.
395-0103-00LPrecision Medicine Restricted registration - show details
Only for CAS in Modern Concepts in Clinical Research and MAS in digital Clinical Research
3 credits3GS. Modica, A. Ghosh, C. Wolfrum
AbstractPrecision Medicine is a new approach in health care aiming to deliver personalised prevention and treatment for human diseases by considering individual differences in lifestyle, environment, and biology. As Precision Medicine is a multidisciplinary approach, the content of this course includes topics in genetics, epigenetics, pharmacogenetics.
Learning objectiveThe course enables participants to...

1. describe the difference between traditional and precision medicine, the goal of precision medicine, and of different patterns of inheritance.

2. recall genetic definitions and genetic variants, and explain how to study genetic variants.

3. explain different next generation sequencing (NGS) technologies and standard NGS data analysis workflow for Mendelian diseases.

4. demonstrate steps involved in variant analysis and interpretation, and how to use public repositories to interpret variants of interest.

5. explain different types of omics data.

6. describe the difference between screening and diagnostic genetic tests

7. describe how to identify patients who might be candidates for whole genome sequencing.

8. report on risks, benefits and limit actions of genomic testing in individuals interested in learning about their future risks, and report on positive, negative, uncertain and unexpected whole genome test results in collaboration with genetic specialists.

9. communicate risks, benefits, and limitations of whole genome sequencing, interpret the results from testing.

10. describe examples of complicated ethical or clinical situations in personalised medicine, name ethical issues that arise, and identify behaviors to deal with ethical issues.

11. describe variability in drug response and examples of drug therapy and adverse drug reactions, explain how to interpret the pharmacogenomic test results, explain what pharmacogenomic tests are available if a patient is a candidate for pharmacogenomic testing.

12. explain analytic and clinical validity of pharmacogenomic tests, describe adverse drug reactions and the mechanisms underlying the variability in drug response.

13. show how to handle biological samples, use the laboratory equipment and infrastructure, explain how to genotype biological samples for a genetic disease, and how to evaluate and communicate results.
395-0302-00LNutrition in Metabolic Disease Restricted registration - show details
Does not take place this semester.
Only for CAS in Nutrition in Medicine and MAS in digital Clinical Research
3 credits2GC. Wolfrum, F. von Meyenn
Abstract
Learning objective
752-6001-AALIntroduction to Nutritional Science Information
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
3 credits6RM. B. Zimmermann, C. Wolfrum
AbstractThis course introduces basic concepts of micro- and macronutrient nutrition. Micronutrients studied include fat-soluble and water-soluble vitamins, minerals and trace elements. Macronutrients include proteins, fat and carbohydrates. Special attention is given to nutrient digestion, bioavailability, metabolism and excretion with some focus on energy metabolism.
Learning objectiveTo introduce the students to the both macro- and micronutrients in relation to food and metabolism.
ContentThis is a self-study course.
The course is devided into two parts: micronutrients are given by and macronutrients a. The micronutrients include fat-soluble vitamins, water-soluble vitamins, minerals and trace elements. The part on macronutrients introduces basic nutritional aspects of proteins, fats, carbohydrates and energy metabolism.
Lecture notesA reading list will be provided to the students detailing chapters and lecture slides to be studied
LiteraturePresent Knowledge in Nutrition; Edited by: J.W. Erdman Jr., I.A. Macdonald and S.H. Zeisel; 10th edition; International Life Sciences Institute; ISBN 978-0-470-95917-6
752-6001-00LIntroduction to Nutritional Science3 credits2VM. B. Zimmermann, C. Wolfrum
AbstractThis course introduces basic concepts of micro- and macronutrient nutrition. Micronutrients studied include fat-soluble and water-soluble vitamins, minerals and trace elements. Macronutrients include proteins, fat and carbohydrates. Special attention is given to nutrient digestion, bioavailability, metabolism and excretion with some focus on energy metabolism.
Learning objectiveTo introduce the students to the both macro- and micronutrients in relation to food and metabolism.
ContentThe course is devided into two parts. The lectutres on micronutrients are given by Prof. Zimmermann and the lectures on macronutrients are given by Prof. Wolfrum. Prof. Zimmermann discusses the micronutrients, including fat-soluble vitamins, water-soluble vitamins, minerals and trace elements. Prof. Wolfrum introduces basic nutritional aspects of proteins, fats, carbohydrates and energy metabolism. The nutrients are described in relation to digestion, absorption and metabolism. Special aspects of homeostasis and homeorhesis are emphasized.
Lecture notesThere is no script. Powerpoint presentations will be made available.
LiteratureElmadfa I & Leitzmann C: Ernährung des Menschen
UTB Ulmer, Stuttgart, 4. überarb. Ausgabe 2004
ISBN-10: 3825280365; ISBN-13: 978-3825280369

Garrow JS and James WPT: Human Nutrition and Dietetics
Churchill Livingstone, Edinburgh, 11th rev. ed. 2005
ISBN-10: 0443056277; ISBN-13: 978-0443056277
752-6003-00LIntroduction to Nutritional Science Information Restricted registration - show details
Only for Agricultural Science BSc.
2 credits1.5VM. B. Zimmermann, C. Wolfrum
AbstractThis course introduces basic concepts of micro- and macronutrient nutrition. Micronutrients studied include fat-soluble and water-soluble vitamins, minerals and trace elements. Macronutrients include proteins, fat and carbohydrates.
Learning objectiveTo introduce the students to the both the macro- and the micronutrients.
ContentThe lectutres on micronutrients are given by Prof. Zimmermann and the lectures on macronutrients are given by Prof. Wolfrum. Prof. Zimmermann discusses the micronutrients, including fat-soluble vitamins, water-soluble vitamins, minerals and trace elements. Prof. Wolfrum introduces basic nutritional aspects of proteins, fats, carbohydrates and energy metabolism.
Lecture notesThere is no script. Powerpoint presentations will be made available.

Moodle Kurs: https://moodle-app2.let.ethz.ch/course/view.php?id=17957
LiteratureElmadfa I & Leitzmann C: Ernährung des Menschen
UTB Ulmer, Stuttgart, 4. überarb. Ausgabe 2004
ISBN-10: 3825280365; ISBN-13: 978-3825280369

Garrow JS and James WPT: Human Nutrition and Dietetics
Churchill Livingstone, Edinburgh, 11th rev. ed. 2005
ISBN-10: 0443056277; ISBN-13: 978-0443056277