Christian Wolfrum: Catalogue data in Spring Semester 2021

Name Prof. Dr. Christian Wolfrum
FieldTranslational Nutrition Biology
VP Forschung
ETH Zürich, HG F 57
Rämistrasse 101
8092 Zürich
Telephone+41 44 632 20 39
DepartmentHealth Sciences and Technology
RelationshipFull Professor and Vice President of Research

376-0004-01LLab Course in Health Sciences and Technology Restricted registration - show details
Only for Health Sciences and Technology BSc.
2 credits2PR. Müller, M. Sommerhalder, C. Wolfrum
AbstractSelected experiments in the area of health sciences and technology as introduction to scientific working.
ObjectiveStudents should understand the methods of scientific working which they will apply in various experiments.
ContentData collection, data presentation and discussion (partially including reporting) in the following experiments:
- Human vs. pneumatic muscle
- Muscle activity and strength
- Balance / sensorimotor function
- Stress-strain relation
- Molecular diagnosis
- Literature research
376-0006-02LLaboratory Course in Molecular Biology Restricted registration - show details 2 credits2PC. Wolfrum, K. De Bock, C. Ewald, M. Ristow
AbstractIntroduction to experimental molecular biology using physiological examples.
ObjectivePractical experience of molecular biology. Learning of fundamental research methods.
ContentProtein analysis , cell culture, quantification of RNA.
Lecture notesEin Skript zum Praktikum wird abgegeben.
Prerequisites / NoticeCell Biology
376-0008-00LAdvanced Physiology and Pathophysiology Restricted registration - show details
Only for Health Sciences and Technology BSc.
4 credits4VK. De Bock, O. Bar-Nur, M. Detmar, G. A. Kuhn, M. Ristow, G. Schratt, C. Spengler, C. Wolfrum, M. Zenobi-Wong
AbstractIn-depth theory to molecular and pathophysiological aspects of nerves, muscles, heart , circulatory , respiratory and sensory organs .
ObjectiveIn-depth knowledge of anatomy and physiology.
ContentMolecular fundamentals of physiological processes, processes of disease development.
Prerequisites / NoticeLanguage of teaching in this course is German/English depending on the teacher
376-0209-00LMolecular Disease Mechanisms6 credits4VC. Wolfrum, H. Gahlon, M. Kopf
AbstractIn this course the mechanisms of disease development will be studied. Main topics will be:

1. Influence of environmental factors with an emphasis on inflammation and the immune response.
2. Mechanisms underlying disease progression in metabolic disorders, integrating genetic and environmental factors.
3. Mechanisms underlying disease progression in cancer, integrating genetic and environment
ObjectiveTo understand the mechanisms governing disease development with a special emphasis on genetic and environmental associated components
Lecture notesAll information can be found at:

The enrollment key will be provided by email
377-0407-00LPrecision Medicine: Theory and Hands-on Exercises Restricted registration - show details
Only for Human Medicine BSc.
5 credits1V + 4PC. Wolfrum, S. Modica, L. Poveda Mozolowski
AbstractPrecision Medicine is a new approach in health care aiming to deliver personalized prevention and treatment for human diseases, by taking into account individual differences in lifestyle, environment, and biology. This course consists of a series of theoretical lectures integrated with a final two-week practical part.
ObjectiveThe goal is to obtain the knowledge to conduct genetic analyzes to be able to carry out genetic analyses both experimentally as well as computationally using standardized tools.
ContentThe theory section introduces precision medicine:
- Concepts
- Epigenetics
- Genetic variations
- Screening and diagnosis
- Case studies and therapies
- Genom Editing and modulation
- Big data analysis and interpretation
A virtual lab with scripts, videos and questions/problems to solve with explanatory answers will run during the whole semester in parallel with the lectures.

In the open lab practical course of 1 week (supervised group work) students will put in practice what they have learned in the virtual lab to solve a biological problem consisting of gDNA isolation from biological biopsies, quality control, RFLP-PCR analysis and diagnosis of a genetic disease. Students have to write a report at the end of the practical course describing lab procedures, diagnosis and how to inform patients.
Prerequisites / NoticeVoraussetzung:
LE 401-0683-00L Statistik II
377-0608-00LTranslational Research Internship Restricted registration - show details
Only for Human Medicine BSc
8 creditsJ. Goldhahn, C. Wolfrum
AbstractWithin the Bachelor’s in Human Medicine, the Translational Research Internship is the final step before transferring into the master at a partner university. It is intended to give insight into the transfer “from bench to bedside”, i.e. the translation of research findings to the clinical application, and to prepare for the master thesis.
ObjectiveThe students should…

- present practical examples for the transfer of medical research into practice in a clinical context.
- gain practical clinical skills in a scientific/clinical context.
- learn how to write a short scientific report and how to critically reflect on your own work.
ContentThe Translational Research Internship (TRI) provides an insight into the development process of 'Bench to Bedside'. This should give students the opportunity to put their theoretical knowledge into practice. The TRI is designed to offer students the possibility to acquire skills and experience in a safe and realistic working environment. The TRI is designed for 6 weeks.
Prerequisites / NoticePrerequisite:
LE 377-0405-11L Clinical Research
551-1304-01LPathobiochemistry Information Restricted registration - show details
Only for Human Medicine BSc.
2 credits2GW. Kovacs, R. C. Dechant, C. Wolfrum
AbstractThe course accompanies the “Biochemie” course and covers similar topics (properties of biomolecules, metabolism, signal transduction, motor proteins etc.). However, in this course these topics will be covered from the perspective of the pathological consequences that arise when these molecules and process do not function properly.
ObjectiveThe course's detailed learning goals are available on the course's Moodle page.
Lecture notesThere is no traditional script for this course. Instead the course is supported by a Moodle page through which students have access to all necessary texts, exercises, videos and activities.
LiteratureThe essential course material will be available on the course's Moodle Page in the form of scripts and lesson handouts.
The course does not have an "official" textbook, but students may find a general reference book on the topic interesting. For this purpose the text "Löffler/Petrides Biochemie und Pathobiochemie" ISBN 978-3-642-17971-6 may be interesting.
Prerequisites / NoticeThe course builds on the content of the "Biochemie" course, which runs parallel to this course as well as on the courses "Chemie für Mediziner", "Pharmakologie für Mediziner" and "Molekulare Genetik und Zellbiologie" from the fall semester.
752-6001-AALIntroduction to Nutritional Science Information
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
3 credits6RM. B. Zimmermann, C. Wolfrum
AbstractThis course introduces basic concepts of micro- and macronutrient nutrition. Micronutrients studied include fat-soluble and water-soluble vitamins, minerals and trace elements. Macronutrients include proteins, fat and carbohydrates. Special attention is given to nutrient digestion, bioavailability, metabolism and excretion with some focus on energy metabolism.
ObjectiveTo introduce the students to the both macro- and micronutrients in relation to food and metabolism.
ContentThe course is devided into two parts. The lectutres on micronutrients are given by Prof. Zimmermann and the lectures on macronutrients are given by Prof. Wolfrum. Prof. Zimmermann discusses the micronutrients, including fat-soluble vitamins, water-soluble vitamins, minerals and trace elements. Prof. Wolfrum introduces basic nutritional aspects of proteins, fats, carbohydrates and energy metabolism. The nutrients are described in relation to digestion, absorption and metabolism. Special aspects of homeostasis and homeorhesis are emphasized.
LiteraturePresent Knowledge in Nutrition, 10th Edition
John W. Erdman Jr. (Editor), Ian A. MacDonald (Editor), Steven H. Zeisel (Editor)
ISBN: 978-0-470-95917-6 September 2012 Wiley-Blackwell 1328 Pages