Christian Wolfrum: Catalogue data in Spring Semester 2019

Name Prof. Dr. Christian Wolfrum
FieldTranslational Nutrition Biology
VP Forschung
ETH Zürich, HG F 57
Rämistrasse 101
8092 Zürich
Telephone+41 44 632 20 39
DepartmentHealth Sciences and Technology
RelationshipFull Professor and Vice President of Research

376-0004-01LLab Introduction to Health Sciences and Technology Restricted registration - show details
Only for Health Sciences and Technology BSc.
2 credits2PR. Müller, R. Riener, C. Wolfrum
AbstractSelected experiments in the area of health sciences and technology as introduction to scientific working.
ObjectiveStudents should understand the methods of scientific working which they will apply in various experiments.
376-0006-02LLaboratory Course in Molecular Biology Restricted registration - show details 2 credits2PC. Wolfrum, K. De Bock, C. Ewald, M. Ristow
AbstractIntroduction to experimental molecular biology using physiological examples.
ObjectivePractical experience of molecular biology. Learning of fundamental research methods.
ContentProtein analysis , cell culture, quantification of RNA.
Lecture notesEin Skript zum Praktikum wird abgegeben.
Prerequisites / NoticeCell Biology
376-0008-00LAdvanced Anatomy and Physiology II: Advanced Physiology and Pathophysiology Restricted registration - show details
Only for Health Sciences and Technology BSc.
4 credits4VK. De Bock, O. Bar-Nur, M. Detmar, G. A. Kuhn, M. Ristow, G. Schratt, C. Spengler, C. Wolfrum, M. Zenobi-Wong
AbstractIn-depth theory to molecular and pathophysiological aspects of nerves, muscles, heart , circulatory , respiratory and sensory organs .
ObjectiveIn-depth knowledge of anatomy and physiology.
ContentMolecular fundamentals of physiological processes, processes of disease development.
376-0209-00LMolecular Disease Mechanisms6 credits4VC. Wolfrum, H. Gahlon, M. Kopf
AbstractIn this course the mechanisms of disease development will be studied. Main topics will be:

1. Influence of environmental factors with an emphasis on inflammation and the immune response.
2. Mechanisms underlying disease progression in metabolic disorders, integrating genetic and environmental factors.
3. Mechanisms underlying disease progression in cancer, integrating genetic and environment
ObjectiveTo understand the mechanisms governing disease development with a special emphasis on genetic and environmental associated components
Lecture notesAll information can be found at:

The enrollment key will be provided by email
377-0405-00LFundamentals of Research and Ethics Restricted registration - show details
Only for Human Medicine BSc.
5 credits5VH. C. Bucher, E. Vayena, C. Wolfrum, A. Blasimme, C. Brall, F. Gille, M. Ienca, further lecturers
AbstractOn the one hand, this module teaches basic knowledge for a critical study of literature with a close relation to clinical decision making as well as the fundamentals of clinical research methodology. On the other hand, methods of personalized medicine and related ethical problems in medical and biomedical research are discussed.
ObjectiveThis module is intended to enable students to critically appreciate scientific literature and to plan clinical trials themselves, and to recognize and analyze ethical controversial situations in everyday medical practice.
ContentThe sub-module 'Clinical Research' contains the following aspects:
- Basic principles of evidence assessment (validity, clinical relevance and external validity of evidence) on the basis of clinical case vignettes (diagnostics, therapy, screening).
- Development and presentation of a clinical trial protocol.
The ‘Ethics in Medicine and Health Care’ sub-module contains the following ethical issues:
- Doctor-patient relationship
- End-of-life decisions
- Reproductive choices
- Techniques such as genetic testing, genome sequencing, Big Data, Artificial Intelligence
The submodule 'Personalized Medicine' contains the following aspects:
- Introduction to precision medicine
- Mendelian inheritance and monogenic diseases
- GWAS and precision medicine
- Biomarkers in precision medicine
377-0407-00LLab Digital Medicine Restricted registration - show details
Only for Human Medicine BSc.
5 credits6PC. Wolfrum
AbstractIn this practical course, students will learn about the latest diagnostic and bioinformatics tools to investigate human genetic variations that are at the bases of individual drug responses. Contents include RNA and DNA applications, generation of libraries, sequencing, data interpretation and analysis, public genomic data set investigations with emphasis on cancer genomics “big data”.
ObjectiveThe goal is to get the right knowledge to perform genetic analyses to finally predict as well as to precisely perform as more personal as possible diagnosis and therapies for human diseases.
752-6001-AALIntroduction to Nutritional Science Information
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
3 credits6RM. B. Zimmermann, C. Wolfrum
AbstractThis course introduces basic concepts of micro- and macronutrient nutrition. Micronutrients studied include fat-soluble and water-soluble vitamins, minerals and trace elements. Macronutrients include proteins, fat and carbohydrates. Special attention is given to nutrient digestion, bioavailability, metabolism and excretion with some focus on energy metabolism.
ObjectiveTo introduce the students to the both macro- and micronutrients in relation to food and metabolism.
ContentThe course is devided into two parts. The lectutres on micronutrients are given by Prof. Zimmermann and the lectures on macronutrients are given by Prof. Wolfrum. Prof. Zimmermann discusses the micronutrients, including fat-soluble vitamins, water-soluble vitamins, minerals and trace elements. Prof. Wolfrum introduces basic nutritional aspects of proteins, fats, carbohydrates and energy metabolism. The nutrients are described in relation to digestion, absorption and metabolism. Special aspects of homeostasis and homeorhesis are emphasized.
LiteratureElmadfa I & Leitzmann C: Ernährung des Menschen
UTB Ulmer, Stuttgart, 4. überarb. Ausgabe 2004
ISBN-10: 3825280365; ISBN-13: 978-3825280369

Garrow JS and James WPT: Human Nutrition and Dietetics
Churchill Livingstone, Edinburgh, 11th rev. ed. 2005
ISBN-10: 0443056277; ISBN-13: 978-0443056277
752-6002-00LAdvanced Topics in Nutritional Science Information 3 credits2VV. Galetti, J. M. Sych, C. Wolfrum
AbstractThe course gives an introduction to dietary recommendations and nutrient requirements at different stages of the life cycle. It also includes lectures on specific diets, e.g. vegetarianism and weight loss, as well as important micronutrients and other food components and their interactions.
ObjectiveThe learning objectives are improved student understanding of: 1) the dietary recommendations and nutrient requirements of populations at different stages of the life cycle; 2) the effect of different diets on health; and 3) certain micronutrients and other nutritionally important food components.
ContentThe course gives a brief introduction into different areas of human nutrition. Including: 1) Dietary recommendations and the nutrient requirements at different stages of the life cycle, including pregnancy and lactation, childhood and adolescence, adults and elderly. 2) The influence of specific diets (e.g. vegetarianism, weight loss diets) on health. 3) Specific nutrients (e.g. iron and biological active ingredients) and their interactions.
Lecture notesThe lecture details and teaching slides will be available online