Jean-Christophe Leroux: Catalogue data in Autumn Semester 2022 |  |
| Name | Prof. Dr. Jean-Christophe Leroux |
| Field | Drug Formulation and Delivery |
| Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 301 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 73 10 |
| jean-christophe.leroux@pharma.ethz.ch | |
| URL | http://www.galenik.ethz.ch |
| Department | Chemistry and Applied Biosciences |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 511-0007-00L | Scientific Writing and Presenting  Only for Pharmaceutical Sciences MSc. | 2 credits | 2G | J. A. Hiss, A. Burden, J. Dolenc, J.‑C. Leroux, O. Renn, C. Steuer | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This introductory class provides an overview of the basic scientific writing techniques and a guideline to presenting scientific data, together with guided exercises and hands-on training. It is devised to accompany the research projects within the curriculum of the MSc in Pharmaceutical Sciences. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The class enables the participants to prepare their own scientific texts and oral presentations, and critically assess the quality of the presentation of scientific data. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The participants receive an introduction to basic formal aspects of scientific writing and the design of graphical elements. Lectures and topical seminars alternate with practical task for the participants, which will be evaluated in a peer-to-peer setting. Performance feedback is provided by both the teachers and the peers. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 535-0001-00L | Introduction to Pharmaceutical Sciences I | 2 credits | 2V | J. Hall, C. Halin Winter, S.‑D. Krämer, J.‑C. Leroux, B. Pfeiffer, U. Quitterer, J. Scheuermann, R. Schibli, H. U. Zeilhofer | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Handouts for individual lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Interactive teaching | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 535-0011-00L | Drug Seminar The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences | 5 credits | 9S | J. Hall, A. Burden, K. Eyer, C. Halin Winter, S.‑D. Krämer, J.‑C. Leroux, C. Müller, V. I. Otto, U. Quitterer, J. Scheuermann, R. Schibli, K. Silina, C. Steuer | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The main objectives of this course are: - students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic - students gain in-depth knowledge of the topic investigated - students train their scientific writing and presentation skills - students train their ability to plan a project and work in a team | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences. The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Only for students of MSc Pharmacy and MSc Pharmaceutical Sciences. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 535-0421-AAL | Galenical Pharmacy I+II Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 4 credits | 7R | J.‑C. Leroux | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Principles and technologies for the manufacturing of dosage forms and drug delivery systems. Knowledge of pharmaceutical excipients, materials, containers, liquid, solid and semi-solid dosage forms, their production, function, quality and application. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Knowledge of the most important pharmaceutical excipients, materials, containers, liquid, solid and semi-solid dosage forms, of their production, function, quality, stability and application. Comprehension of the molecular interactions in solid state, solution and colloidal systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Introduction and overview of important fundamentals, principles and technologies for the development and manufacturing of dosage forms and drug delivery systems. Overview of the most important pharmaceutical excipients and polymers, their structure, properties and processing; importance of materials properties for containers. Pharmaceutical solvents, fundamentals of solubility and solubilization of drugs. Water treatment processes, sterilization techniques and quality requirements of pharmaceutical water. Parenteral dosage forms and liquid ophthalmics. Surfactants, micelle formation and colloidal systems. Liquid suspensions and emulsions. Stabilization measures in dosage forms. Important fundamentals, principles and technologies for the development and manufacturing of solid dosage forms and drug delivery systems. Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Formulation of biologics. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration. Packaging. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | M. E. Aulton and K. M. G. Taylor, Aulton's Pharmaceutics: The design and manufacture of medicines, 6th ed, Elsevier, Edinburgh, 2022. (excepting chapters 7, 13, 14, 19, 22, 25, 46, 47 and 48 and 49) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Competencies |
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| 535-0421-00L | Galenical Pharmacy I | 2 credits | 2G | J.‑C. Leroux, E. Giger | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Principles and technologies for the manufacturing of dosage forms and drug delivery systems. Knowledge of pharm. excipients, materials, containers, liquid and semi-solid dosage forms, their production, function, quality and application. Comprehension of molecular interactions in solution and colloidal systems. Comprehension of interfacial phenomena and stabilization measures in dosage forms. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Knowledge of the most important pharmaceutical excipients, materials, containers, liquid and semi-solid dosage forms, of their production, function, quality, stability and application. Comprehension of the molecular interactions in solution and colloidal systems. Comprehension of interfacial phenomena and stabilization measures in disperse dosage forms. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Introduction and overview of important fundamentals, principles and technologies for the development and manufacturing of dosage forms and drug delivery systems. Overview of the most important pharmaceutical excipients and polymers, their structure, properties and processing; importance of materials properties for containers. Pharmaceutical solvents, fundamentals of solubility and solubilization of drugs. Water treatment processes, sterilization techniques and quality requirements of pharmaceutical water. Parenteral dosage forms and liquid ophthalmics. Surfactants, micelle formation and colloidal systems. Liquid suspensions and emulsions. Stabilization measures in dosage forms. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | L.V. Allen Jr, T. B. McPherson, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, 12th Ed, Wolters Kluwer, Philadelphia 2023. M. E. Aulton and K. M. G. Taylor, Aulton's Pharmaceutics: The design and manufacture of medicines, 6th ed, Elsevier, Edinburgh, 2022. L. Felton, Remington - Essentials of Pharmaceutics, Pharmaceutical Press, London, 2013. Sinko P.J., Martin's Physical Pharmacy and Pharmaceutical Sciences, 7th ed, Wolters Kluwer, Philadelphia, 2017. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Language: German and English | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 535-0423-00L | Drug Delivery and Drug Targeting | 2 credits | 1.5V | J.‑C. Leroux | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The students gain an overview on current principles, methodologies and systems for controlled delivery and targeting of drugs. This enables the students to understand and evaluate the field in terms of scientific criteria. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The students dispose of an overview on current principles and systems for the controlled delivery and targeting of drugs. The focus of the course lies on developing a capacity to understand the involved technologies and methods, as well as an appreciation of the chances and constraints of their therapeutic usage, with prime attention on anticancer drugs, therapeutic peptides, proteins, nucleic acids and vaccines. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course covers the following topics: drug targeting and delivery principles, macromolecular drug carriers, liposomes, micelles, micro/nanoparticles, gels and implants, administration of vaccines, targeting at the gastrointestinal level, synthetic carriers for nucleic acid drugs, ophthalmic devices, novel trends in transdermal and nasal drug delivery and 3D printing of drug delivery systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Selected lecture notes, documents and supporting material will be directly provided or may be downloaded from the course website. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | A.M. Hillery, K. Park. Drug Delivery: Fundamentals & Applications, second edition, CRC Press, Boca Raton, FL, 2017. B. Wang B, L. Hu, T.J. Siahaan. Drug Delivery - Principles and Applications, second edition, John Wiley & Sons, Hoboken NJ, 2016. Further references will be provided in the course. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K. Eyer, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | State-of-the-art information on drug discovery and development. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||