Jean-Christophe Leroux: Catalogue data in Spring Semester 2022 |  |
| Name | Prof. Dr. Jean-Christophe Leroux |
| Field | Drug Formulation and Delivery |
| Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 301 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 73 10 |
| jean-christophe.leroux@pharma.ethz.ch | |
| URL | http://www.galenik.ethz.ch |
| Department | Chemistry and Applied Biosciences |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 535-0419-00L | Laboratory Course in Galenical Pharmacy  | 5 credits | 9P | J.‑C. Leroux, E. Giger | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The students gain knowledge on excipients, the preparation of simple dosage forms under consideration of basic quality assurance requirements, on quality control of medicaments and pharmacopoeial requirements. This enables them to analyse and understand simple galenical problems, to study them experimentally, and to evaluate and present the data in a scientific format. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | „Introductory stations“: The students dispose of knowledge on pharmaceutical excipients, preparation methods for simple important dosage forms, and related quality assurance and quality control aspects. With this knowledge, the students are able to prepare simple dosage forms under basic quality assurance measures and to control the galenical quality of the medicaments. The students also possess knowledge on relevant pharmacopoeial requirements and on contents of formularies and excipients handbooks. „Mini project“: The students are able to comprehend and analyse basic galenical problems in their context. The students are also able to use data and information from the literature and other resources to develop a relevant experimental plan for solving experimentally basic galenical problems under consideration of quality assurance issues. The students are finally able to present and evaluate the experiments and data in a scientifically sound oral presentation and written report (publication style). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | „Introductory stations“: Knowledge, comprehension and application of methods and techniques in the following areas: drug dissolution testing; disintegration of dosage forms; grinding and mixing of powders; granulation; extrusion; pelletization; flowability of powders; true and apparent densities of powders, sieve analyses; specific surfaces of powders; compression and in-process controls; quality control charts and quality control of tablets; fluidized bed and drum coating processes; dispersion and homogenisation of liquid and semi-solid dosage forms; preparation of gels, creams and ointments; preparation of liquid emulsions and suspensions; rheological measurements of viscous systems; particle size measurements by means of laser light diffractometry; surfaced tension of liquid (tensiometry); water purification; sterilisation; sterility testing; freeze-drying; osmometry; conductometry; liposomes. „Mini project“: Preparation of suitable drug formulations based on patient examples. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Printed script on selected methods; manuals and other documents. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Eur. Pharm. (European Pharmacopoeia) USP (United States Pharmacopeia) K.H. Bauer, K.-H. Frömming, C. Führer Lehrbuch der pharmazeutisK.H. Bauer, K.-H. Frömming, C. Führer, Lehrbuch der pharmazeutischen Technologie. 8. Auflage, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2006 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Teaching methods: Demonstrations; Practical guided exercises; Self-guided literature research; Questionnaires; Seminars; Self-guided experimental project work. Requirements: Laboratory course in Pharmaceutical Analytics passed Lecture in Galenical Pharmacy I Lecture in Galenical Pharmacy II in the same semester or previously Safety concept: https://chab.ethz.ch/studium/bachelor1.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 535-0421-AAL | Galenical Pharmacy I+II Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 4 credits | 7R | J.‑C. Leroux | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Principles and technologies for the manufacturing of dosage forms and drug delivery systems. Knowledge of pharmaceutical excipients, materials, containers, liquid, solid and semi-solid dosage forms, their production, function, quality and application. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Knowledge of the most important pharmaceutical excipients, materials, containers, liquid, solid and semi-solid dosage forms, of their production, function, quality, stability and application. Comprehension of the molecular interactions in solid state, solution and colloidal systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Introduction and overview of important fundamentals, principles and technologies for the development and manufacturing of dosage forms and drug delivery systems. Overview of the most important pharmaceutical excipients and polymers, their structure, properties and processing; importance of materials properties for containers. Pharmaceutical solvents, fundamentals of solubility and solubilization of drugs. Water treatment processes, sterilization techniques and quality requirements of pharmaceutical water. Parenteral dosage forms and liquid ophthalmics. Surfactants, micelle formation and colloidal systems. Liquid suspensions and emulsions. Stabilization measures in dosage forms. Important fundamentals, principles and technologies for the development and manufacturing of solid dosage forms and drug delivery systems. Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | M. E. Aulton and K. M. G. Taylor, Aulton's Pharmaceutics: The design and manufacture of medicines, 6th ed, Elsevier, Edinburgh, 2021. (excepting chapters 7, 13, 14, 19, 22, 25, 46, 47 and 48 and 49) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Competencies |
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| 535-0422-00L | Galenical Pharmacy II Prerequisite: Galenical Pharmacy I (535-0421-00L) | 2 credits | 2G | J.‑C. Leroux, E. Giger | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Continues Galenical Pharmacy I. Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Suppositories. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Introduction and overview of important fundamentals, principles and technologies for the development and manufacturing of dosage forms and drug delivery systems. In continuation of Galenical Pharmacy I. The students dispose of knowledge of properties, function, quality and application of dosage forms. The following topics will be covered: Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Suppositories. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration. Formulation of biotechnology products. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Overview of important fundamentals, principles and technologies for the development and manufacturing of solid dosage forms and drug delivery systems. Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration. Packaging. Flavoring. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Scripts, documentations to the lectures and additional supporting materials can be either downloaded via the indicated link to the course , or they will be directly provided at each lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | A.T. Florence - An introduction to clinical pharmaceutics. Pharmaceutical Press, London 2010. L.V. Allen, N.G. Popovich, H.C. Ansel, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, 12th Ed, Wolters Kluwer, Philadelphia 2021. L. Felton, Remington - Essentials of Pharmaceutics, Pharmaceutical Press, London, 2013. M.E. Aulton. Pharmaceutics - The design and manufacture of medicines. 6th Ed. Elsevier, Philadelphia, 2021. Sinko P.J., Martin's Physical Pharmacy and Pharmaceutical Sciences, 7th ed, Wolters Kluwer, Philadelphia, 2017. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prior attendance of Galenical Pharmacy I is recommended. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K.‑H. Altmann, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | State-of-the-art information on drug discovery and development. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||