Jonathan Hall: Katalogdaten im Herbstsemester 2023 |  |
| Name | Herr Prof. Dr. Jonathan Hall |
| Lehrgebiet | Pharmazeutische Chemie |
| Adresse | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 437 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telefon | +41 44 633 74 35 |
| Fax | +41 44 633 13 69 |
| jonathan.hall@pharma.ethz.ch | |
| Departement | Chemie und Angewandte Biowissenschaften |
| Beziehung | Ordentlicher Professor |
| Nummer | Titel | ECTS | Umfang | Dozierende | |||||||||||||||||||||||||||||||||||||||||
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| 511-0000-00L | Drug Discovery and Development  | 2 KP | 1G + 2S | J. Hall, U. Thibaut, K.‑H. Altmann, M. Arand, J. Scheuermann, R. Schibli, H. U. Zeilhofer | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This course provides an overview over the concepts and processes employed in today's drug discovery and development. It has an introductory character but will also provide more detailed insights employing real life examples. The course combines lectures and interactive elements with active participation of the students. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Students - Understand the drug discovery process and can explain major approaches and relevant technical terms (for details see lecture notes). - Understand and appreciate the content and timing of drug development process steps, development phases and decision criteria. - Understand the concepts underlying drug product development through all the phases from preclinical and clinical development to regulatory submission, approval and market launch. - Can differentiate between small molecule drug development and biological drug development. - Understand the most important differences for drug development and approval between the EU and USA pharma markets with regard to legal and regulatory requirements. | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Course unit comprises weekly lectures covering the early phases of target and drug discovery (535-0901-01 S "From A to Z in Drug Discovery and Development I") with group work in the area of Drug Development (511-0000-00 G). The latter course lasts 2 full days (Days 1 and 2) and comprises both lectures and group work: inter alia an introduction to the entire suite of drug product development processes in the pharmaceutical industry, covering preclinical research and development, clinical development, regulatory processes and market launch. R&D support processes such as project management, quality management, pharmacovigilance and pharmacoeconomics will be covered as well as organizational and governance aspects of the pharmaceutical industry. In addition, important success factors for a later career in the pharmaceutical industry will be briefly discussed at the end of day 2 of the course. | ||||||||||||||||||||||||||||||||||||||||||||
| Skript | Will be published on "mystudies" | ||||||||||||||||||||||||||||||||||||||||||||
| Literatur | G. Nahler (Hrsg.) Dictionary of pharmaceutical medicine, Springer, Wien, 2013 (3rd edition) Further readings will be listed in the lecture notes. | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | This course provides the essential basic knowledge required for the industry-specific modules of the spring semester. Safety conceptt: https://chab.ethz.ch/studium/bachelor1.html | ||||||||||||||||||||||||||||||||||||||||||||
Kompetenzen |
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| 535-0001-00L | Einführung in die Pharmazeutischen Wissenschaften I | 2 KP | 2V | J. Hall, S.‑D. Krämer, J.‑C. Leroux, B. Pfeiffer, U. Quitterer, J. Scheuermann, R. Schibli, Y. Yamauchi, H. U. Zeilhofer | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Erste Identifizierung mit den Pharmazeutischen Wissenschaften; Motivation für die Profilierung im Bereich der Naturwissenschaften (erste zwei Studienjahre) als Vorbereitung auf das Fachstudium; Sensibilisierung für die Aufgaben und die Verantwortung einer staatlichen anerkannten Medizinalperson (eidg. Apothekerdiplom); Übersicht über verschiedene Berufsbilder und mögliche Betätigungsfelder. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Erste Identifizierung mit den Pharmazeutischen Wissenschaften; Motivation für die Profilierung im Bereich der Naturwissenschaften als Vorbereitung auf das Fachstudium; Sensibilisierung für die Aufgaben und die Verantwortung einer staatlichen anerkannten Medizinalperson (eidg. Apothekerdiplom); Übersicht über verschiedene Berufsbilder und mögliche Betätigungsfelder. | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Einführung in die verschiedenen Bereiche der Pharmazeutischen Wissenschaften anhand ausgewählter Meilensteine aus Forschung und Entwicklung. Einblick in die Fachprofessuren und deren Forschungsschwerpunkte innerhalb des Netzwerkes Arzneimittel. Sensibilisierung für die Entwicklung der Fähigkeit zu kommunizieren und Information zu verarbeiten. Aufzeigen der Berufsmöglichkeiten in der öffentlichen Apotheke, im Spital, in der Industrie sowie im Gesundheitswesen. | ||||||||||||||||||||||||||||||||||||||||||||
| Skript | Wird teilweise abgegeben. | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Interaktive Lehrveranstaltung | ||||||||||||||||||||||||||||||||||||||||||||
| 535-0011-00L | Drug Seminar | 5 KP | 9S | J.‑C. Leroux, A. Burden, K. Eyer, C. Halin Winter, J. Hall, S.‑D. Krämer, C. Müller, V. I. Otto, U. Quitterer, J. Scheuermann, R. Schibli, K. Silina, C. Steuer | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic and present their work on a one day symposium. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The main objectives of this course are: - students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic - students gain in-depth knowledge of the topic investigated - students train their scientific writing and presentation skills - students train their ability to plan a project and work in a team | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | The Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences. The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. During the course, students work in small teams on a topic of their choice and elaborate an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search/review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester. | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Only for students of MSc Pharmacy and MSc Pharmaceutical Sciences. | ||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 535-0230-00L | Medizinische Chemie I | 2 KP | 2V | J. Hall | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The lectures give an overview of selected drugs and the molecular mechanisms underlying their therapeutic effects in disease. The historical and modern-day methods by which these drugs were discovered and developed are described. Structure-function relationships and the biophysical rules underlying ligand-target interactions will be discussed and illustrated with examples. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Basic understanding of therapeutic agents with respect to molecular, pharmacological and pharmaceutical properties. | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Molecular mechanisms of action of drugs. Structure function and biophysical basis of ligand-target interactions | ||||||||||||||||||||||||||||||||||||||||||||
| Skript | Will be provided in parts before each individual lecture. | ||||||||||||||||||||||||||||||||||||||||||||
| Literatur | - G.L. Patrick, "An Introduction to Medicinal Chemistry", 5th edition, Oxford University Press - D. Steinhilber, M. Schubert-Zsilavecz, H.J. Roth, "Medizinische Chemie", Deutscher Apotheker Verlag Stuttgart (2005) - J.H. Block, J.M. Beale, "Organic Medicinal and Pharmaceutical Chemistry", 11th edition, Lippincott, Williams, Wilkins (2002) - A. Gringauz, "How Drugs Act and Why", Wiley (1997) - R. B. Silverman and M. W. Holladay, "The Organic Chemistry of Drug Design and Drug Action", 3rd edition, Elsevier | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Requirements: Knowledge of physical and organic chemistry, biochemistry and biology. Attendance of Medicinal Chemistry II in the spring semester. For Pharmacy and non-Pharmacy students, Medicinal Chemistry I and II are examined in a SINGLE examination (Jahresprüfung). | ||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 535-0239-00L | Praktikum Medizinische Chemie | 3 KP | 7P | J. Hall, C. Halin Winter, J. Scheuermann | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The course comprises experiments relating to concepts of medicinal chemistry including statistical processing, fitting of experimental data, computer modeling of protein structures, experimental measurement of affinity constants and kinetic dissociation constants for protein ligands. The chemical stability of a drug will be studied. Basic gene cloning and protein expression will be introduced. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Knowledge of experimental methods in drug discovery and development | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Characterisation of the biophysical and biological properties of drugs. | ||||||||||||||||||||||||||||||||||||||||||||
| Skript | Scripts | ||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Original literature | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Requirements: Laboratory course in Pharmaceutical Anaytics; Lecture Medicinal Chemistry I in the same semester or earlier. | ||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 535-0900-00L | Seminars on Drug Discovery and Development | 1 KP | 1K | R. Schibli, K. Eyer, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Vermittlung neuer Erkenntnisse im Bereich Arzneimittelfindung und -entwicklung anhand von Expertenvorträgen aus dem Hochschul- und Industriebereich. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Einblick in aktuelle Forschungsgebiete im Gesamtbereich der Pharmazie. Vermittlung neuer Erkenntnisse im Bereich Arzneimittelfindung und -entwicklung. | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Seminarreihe des Instituts für Pharmazeutische Wissenschaften. Expertinnen und Experten aus Akademia und Industrie berichten über neue Erkenntnisse. | ||||||||||||||||||||||||||||||||||||||||||||
| 535-0901-00L | From A to Z in Drug Discovery and Development | 1 KP | 2S | J. Hall, K.‑H. Altmann, M. Arand, J. Scheuermann, R. Schibli, H. U. Zeilhofer | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The lecture series takes place at the ETH Hönggerberg and covers a variety of major activities involved in drug discovery: selecting drug targets, technologies used in drug discovery, small, medium and large drugs, objectives of the medicinal chemist, assessing drug safety, principles of personalized medicine, designing clinical trials, how intellectual property is protected, as well as others. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The objective of the course is to gain a global understanding of most of the important phases in the discovery and development of modern synthetic and biological drugs, from the first activities to clinical trials. The lecture is intended for students that have an interest in the area and/or may consider a career working in drug discovery. This lecture course complements knowledge and experience gained in the research project performed by the PhD student. | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Thirteen two hour lectures for life-science PhD students and students of the Pharmaceutical Sciences Master, given by experts from the ETH, UZH, USZ and the pharmaceutical industry. Introduction to the modern drug discovery process - Principles of drug pharmacokinetics and drug metabolism - Computer sciences in drug discovery - Drug targets - In vitro methods in drug discovery - Natural products in drug discovery - Medicinal chemistry: Chemical lead selection/optimization - Antibodies and therapeutic proteins: Targets and drugs - In vivo molecular imaging in drug discovery - Drug formulation: Key development consideration, Current new APIs challenges and FDA rising standards - Preclinical safety, adverse drug events and drug-drug interactions - Clinical development steps including trial design - Intellectual property in drug discovery and development | ||||||||||||||||||||||||||||||||||||||||||||
| Literatur | To be distributed during the lecture | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Formally none, but a basic understanding in biochemistry, physiology and chemistry is highly desirable as it will certainly help to get the most from the lectures. | ||||||||||||||||||||||||||||||||||||||||||||
| 535-1001-00L | Praktikum Allgemeine Chemie (für Biol./Pharm. Wiss.) Informationen zum Praktikum am Begrüssungstag. So früh wie möglich in myStudies belegen, weil die Brandschutzkurse mit separatem Aufgebot schon vor dem Praktikumsstart stattfinden. | 6 KP | 8P | S. Gruber, J. Hall | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Einführung in das praktische Arbeiten im chemischen Laboratorium. Der Kurs vermittelt die wesentlichen Arbeitstechniken und behandelt die wichtigsten chemischen Reaktionsarten. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | - Erlernen der grundlegenden Arbeitstechniken im chemischen Laboratorium - Erlernen der Grundlagen des naturwissenschaftlichen Experimentierens - Beobachtung und Interpretation chemischer Vorgänge - Führung eines auswertbaren Laborjournals | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | - Einfache chemische Arbeitstechniken/methoden - Methoden zur Stofftrennung - Physikalische Messungen: Masse, Volumen, pH - Ionische Festkörper (Salze) - Säure/Base-Chemie, Pufferung - Redoxreaktionen - Metallkomplexe - Titrationsmethoden und quantitative Spektroskopie - Einführung in die qualitative Analyse | ||||||||||||||||||||||||||||||||||||||||||||
| Skript | Anleitung zum Praktikum (wird zu Beginn des Kurses an die Studenten abgegeben) Sprache: Deutsch, Englisch auf Anfrage | ||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Allgemeine Chemie für Biologen Latscha & Klein Springer Verlag (ständig neue Auflagen), ist als Ergänzungsliteratur geeignet. | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Der Kurs verursacht Material- und Chemikalienkosten, welche am Ende des Semesters den Studenten belastet werden. Mit Belegung dieses Praktikums bestätigen die Studierenden, alle Sicherheitsinformationen gründlich zu studieren und Anweisungen zu befolgen. | ||||||||||||||||||||||||||||||||||||||||||||
| 551-1309-00L | RNA-Biology Number of participants limited to 17. The enrolment is done by the D-BIOL study administration. | 6 KP | 7P | F. Allain, J. Corn, J. Hall, M. Jinek, S. Jonas, B. Mateescu, R. Santoro, O. Voinnet | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Introduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The students will obtain an overview about the diversity of current RNA-research. They will learn to design experiments and use techniques necessary to analyze different aspects of RNA biology. Through lectures and literature seminars, they will learn about the burning questions of RNA research and discuss approaches to address these questions experimentally. In practical lab projects the students will work in one of the participating laboratories. Finally, they will learn how to present and discuss their data in an appropriate manner. Student assessment is a graded semester performance based on individual performance in the laboratory, the written exam and the poster presentation. | ||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Documentation and recommended literature will be provided at the beginning and during the course. | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | The course will be taught in English. | ||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 551-1409-00L | RNA Biology Lecture Series II: Non-Coding RNAs: Biology and Therapeutics | 4 KP | 2V | J. Hall, M. Stoffel, weitere Dozierende | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This course covers aspects of RNA biology related to the functions of non-coding RNAs as well as their use as drugs to treat diseases. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The students should get familiar with the wide array of roles, which non-coding RNAs play in cellular functions. | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Micro RNAs; computational approaches to miRNAs; micro RNA function in metabolism; viruses and viral RNAs; nucleic acid-based drugs; ncRNA-mediated genome regulation; epigenetic programming of genome remodelling in ciliates; telomerase and telomeres; tRNA biology. http://www.nccr-rna-and-disease.ch/tiki-index.php?page=LectureSeries | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Basic knowledge of cell and molecular biology. | ||||||||||||||||||||||||||||||||||||||||||||