Thierry Hennet: Katalogdaten im Herbstsemester 2017 |
| Name | Herr Prof. Dr. Thierry Hennet (Professor Universität Zürich (UZH)) |
| Adresse | Universität Zürich Winterthurerstrasse 190 Physiologisches Institut 8057 Zürich SWITZERLAND |
| Telefon | 044 635 50 80 |
| Fax | 044 635 68 14 |
| thennet@ethz.ch | |
| Departement | Biologie |
| Beziehung | Dozent |
| Nummer | Titel | ECTS | Umfang | Dozierende | |
|---|---|---|---|---|---|
| 551-1105-00L | Glycobiology | 4 KP | 2V | M. Aebi, T. Hennet | |
| Kurzbeschreibung | Structural principles, nomenclature and different classes of glycosylation. The different pathways of N- and O-linked protein glycosylation and glycolipid biosynthesis in prokaryotes and eukaryotes are discussed. Specific glycan binding proteins and their role in deciphering the glycan code are presented. The role of glycans in infectious diseases, antigen mimicry and autoimmunity are discussed. | ||||
| Lernziel | Detailed knowledge in 1) the different areas of prokaryotic and eukaryotic glycobiology, in particular in the biosynthesis of glycoproteins and glycolipids, 2) the cellular machinery required for these pathways, 3) the principles of carbohydrate/protein interaction, 4) the function of lectins, 5) the role of glycans in infectious disease. | ||||
| Inhalt | Structure and linkages; analytical approaches; N-linked protein glycosylation (ER, Golgi); glycan-assisted protein folding and quality control; O-linked protein glycosylation; glucosaminoglycans; glycolipids; prokaryotic glycosylation pathways; lectins; glycans and infectious disease | ||||
| Skript | handouts | ||||
| Literatur | Introduction to Glycobiology; M.E.Taylor, K.Drickamer, Oxford University Press, 2003 Essentials of Glycobiology (second edition); A.Varki et al. Cold Spring Harbor Laboratory Press, 2009 | ||||
| Voraussetzungen / Besonderes | The course will be in English. It will include the preparation of short essays (marked) about defined topics in Glycobiology. | ||||