Markus Stoffel: Catalogue data in Autumn Semester 2023 |
| Name | Prof. Dr. Markus Stoffel |
| Field | Metabolic Diseases |
| Address | Inst. f. Molecular Health Sciences ETH Zürich, HPL H 36 Otto-Stern-Weg 7 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 45 60 |
| Fax | +41 44 633 13 62 |
| stoffel@biol.ethz.ch | |
| Department | Biology |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||
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| 377-0301-03L | Endocrinology, Metabolism  | 5 credits | 5V | M. Stoffel, F. Beuschlein, A. Hall, C. Wolfrum | ||||||||||||||||||||||||||
| Abstract | Discussion of normal structure and function of the endocrine systems, their interaction with the autonomic nervous system and their role in metabolism. In addition, pathophysiological and clinical aspects, diagnostics and therapeutic concepts of the most important endocrine diseases and related metabolic disorders as well as respective preventive measures are adressed. | |||||||||||||||||||||||||||||
| Learning objective | Upon successful completion of this module, students should: - be able to explain the systematics of the endocrine system; - know the structure and function of the hypothalamus, pituitary gland, adrenal gland, endocrine pancreas, thyroid gland, ovaries, testes; - know the principles and regulation of bone, calcium and phosphate metabolism, energy balance, glucose metabolism, lipid metabolism, blood pressure; - know the hormonally regulated metabolic processes (carbohydrates, protein and fat); - know the most important endocrine diseases and tumors, their development, clinic, diagnostics and therapy; - know the most important measures for the prevention of metabolic diseases and the underlying mechanisms. | |||||||||||||||||||||||||||||
| Content | In this module, students learn about anatomy, physiology, and pathophysiology of the endocrine glands, as well as the clinical, diagnostic, therapeutic, and preventive aspects of the most important endocrine diseases. This includes: - Systematics of the endocrine system: structure and anatomical location of the various endocrine glands. - Neuronal innervation and vascular supply area of the endocrine glands. - Hormone classes: Protein and polypeptide hormones, amino and amino acid derivatives steroid hormones, biosynthesis of protein and polypeptide hormones, biosynthesis of amino and amino acid derivatives, biosynthesis of steroid hormones, storage of hormones, secretion of hormones, transport of hormones, half-lives, degradation and excretion of hormones. - Transmission of information by hormones: hormone action at receptors, structure and function of membrane-associated hormone receptors, structure and function of nuclear receptors, regulation of hormone secretion. - Structure and function of the hypothalamus, structure and function of the pituitary gland. - Structure and function of the thyroid gland, under- and over-functioning of the thyroid gland, principles of diagnostics and therapy of thyroid diseases. Symptoms, medical history and clinical examination of thyroid diseases, - Bones, calcium and phosphate metabolism. - Regulation of glucose, lipid and protein metabolism, eating disorders, etiology, diagnostics, therapy and prevention of adpositas. - Structure and function of endocrine pancreas, pathogenesis of different types of diabetes mellitus. Principles of diagnostics and therapy and prevention of type 1 and type 2 diabetes, risk factors and complications. Symptoms, medical history and clinical examination in diabetes mellitus, - Structure and function of the adrenal gland, pathogenesis, principles of diagnostics and therapy of diseases with hyper- and hypofunction of the adrenal gland. Symptoms, anamnesis and clinical examination in case of hyper- and hypofunction of the adrenal gland. - Structure and function of the ovaries and testis, principles of reproductive physiology. | |||||||||||||||||||||||||||||
| Lecture notes | There is no traditional script for this course. Instead the course is supported by a Moodle page through which students have access to all necessary texts, exercises, videos and activities. | |||||||||||||||||||||||||||||
| Literature | The essential course material will be available on the course's Moodle Page in the form of scripts and lesson handouts. The course does not have an "official" textbook, but students may find a general reference book on the topic interesting. For this purpose the text "Endokrinologie und Stoffwechsel” von Stefan Fischli und Giatgen A. Spinas (Herausgeber), Thieme Verlag, may be helpful. | |||||||||||||||||||||||||||||
| Prerequisites / Notice | The course builds on the content of the "Chemie für Mediziner", "Biochemie", “Pathobiochemie”, "Pharmakologie für Mediziner" and "Molekulare Genetik und Zellbiologie" course and “Nutrition and Digestion”. | |||||||||||||||||||||||||||||
| 551-0127-00L | Fundamentals of Biology III: Multicellularity | 8 credits | 6G | M. Stoffel, M. Künzler, O. Y. Martin, U. Suter, S. Werner, A. Wutz, S. C. Zeeman | ||||||||||||||||||||||||||
| Abstract | The lecture conveys the fundamental concepts underlying multicellularity with an emphasis on the molecular basis of multicellular biological systems and their functional integration into coherent wholes. The structural and functional specialization in multicellular organisms will be discussed by highlighting common and specific functions in fungi, plants, and animals (including humans). | |||||||||||||||||||||||||||||
| Learning objective | 1.Students can describe advantages and challenges associated with being multicellular and outline independent solutions that organisms have developed to cope with the challenges of complex multicellularity . 2.Students can explain how the internal and external structures of fungi, plants and animals function to support survival, growth, behavior, and reproduction. 3.Students can explain the basic pathways and mechanisms of cellular communication regulating cellular behavior (cell adhesion, metabolism, proliferation, reproduction, development). 4.Students can describe how a single cell develops from one cell into many, each with different specialized functions. | |||||||||||||||||||||||||||||
| Content | The lecture introduces the structural and functional specialization in fungi, plants and animals, including humans. After providing an overview on the diversity of eukaryotic organisms, the lecture will discuss how fungi, plants, animals and humans have evolved structures and strategies to cope with the challenges of multicellularity. The molecular basis underlying communication, coordination and differentiation will be conveyed and complemented by key aspects of reproduction, metabolism development, and regeneration. Topics include form and function of fungi and plants, human anatomy and physiology, metabolism, cell signaling, adhesion, stem cells, regeneration, reproduction, and development. | |||||||||||||||||||||||||||||
| Literature | Alberts et al. 'Molecular Biology of the Cell' 6th edition Smith A.M., et al. “Plant Biology” Garland Science, New York, Oxford Campbell “Biology”, 11th Edition | |||||||||||||||||||||||||||||
| Prerequisites / Notice | Some lecture are held in English. | |||||||||||||||||||||||||||||
Competencies |
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| 551-1409-00L | RNA Biology Lecture Series II: Non-Coding RNAs: Biology and Therapeutics | 4 credits | 2V | J. Hall, M. Stoffel, further lecturers | ||||||||||||||||||||||||||
| Abstract | This course covers aspects of RNA biology related to the functions of non-coding RNAs as well as their use as drugs to treat diseases. | |||||||||||||||||||||||||||||
| Learning objective | The students should get familiar with the wide array of roles, which non-coding RNAs play in cellular functions. | |||||||||||||||||||||||||||||
| Content | Micro RNAs; computational approaches to miRNAs; micro RNA function in metabolism; viruses and viral RNAs; nucleic acid-based drugs; ncRNA-mediated genome regulation; epigenetic programming of genome remodelling in ciliates; telomerase and telomeres; tRNA biology. http://www.nccr-rna-and-disease.ch/tiki-index.php?page=LectureSeries | |||||||||||||||||||||||||||||
| Prerequisites / Notice | Basic knowledge of cell and molecular biology. | |||||||||||||||||||||||||||||
| 551-1515-00L | Insulin Signaling Number of participants limited to 15. The enrolment is done by the D-BIOL study administration. | 6 credits | 7P | M. Stoffel | ||||||||||||||||||||||||||
| Abstract | Introduction to the physiological and biochemical action of insulin signaling and its role in the fasted/feeding response and in obesity and diabetes. | |||||||||||||||||||||||||||||
| Learning objective | The students will obtain an overview about the current topics of research in insulin signaling and how it impacts on growth, metabolism and cell differentiation. They will learn to design experiments and use techniques necessary to analyze different aspects of insulin signaling,including physiological actions in whole animals as well as in tissue culture. Through lectures and literature seminars, they will learn about the open questions of insulin signaling research and discuss approaches to address these questions experimentally. In practical lab projects the students will perform physiological in vivo studies as well as biochemical experiments. Finally, they will learn how to present and discuss their data. Student assessment is a graded semester performance based on individual performance in the laboratory, a written exam and the lab data presentation. | |||||||||||||||||||||||||||||