Julia Vorholt-Zambelli: Catalogue data in Autumn Semester 2022

Name Prof. Dr. Julia Vorholt-Zambelli
Institut für Mikrobiologie
ETH Zürich, HCI F 429
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
Telephone+41 44 632 55 24
Fax+41 44 633 13 07
RelationshipFull Professor

551-0125-00LFundamentals of Biology I: From Molecules to the Biochemistry of Cells6 credits5GJ. Vorholt-Zambelli, N. Ban, R. Glockshuber, K. Locher, J. Piel
AbstractThe lecture provides an introduction to the basics of biochemistry and molecular biology as well as evolutionary principles. The focus is on bacteria and archaea under consideration of universal concepts.
ObjectiveIntroduction to biochemistry, molecular biology and evolutionary principles
ContentThe lecture introduces biology as an interdisciplinary science. Links to physics and chemistry will manifest as biological processes that operate within the laws of thermodynamics and are rooted in elements, molecules and chemical reactions. The transition from geochemistry to biochemistry is discussed and considered in relation to the origin of life. Evolutionary principles are introduced and resulting processes are used as a guiding principle. Unifying concepts in biology are presented, including the structure and function of cellular macromolecules and the ways in which hereditary information is encoded, decoded and replicated. Central principles of universal energy conversion are looked at, starting from redox processes and focusing on bacteria and archaea. Finally, biological processes are put into an ecosystems perspective.

The lecture is divided into different sections:
1. Geochemical perspectives on Earth and introduction to evolution
2. Building blocks of life
3. Macromolecules: Proteins
4. Membranes and transport across the plasma membrane
5. Universal mechanisms of inheritance, transcription and translation
6. Reaction Kinetics, binding equilibria and enzymatic catalysis
7. Essentials of Catabolism
8. Essentials of Anabolism
9. Metabolism and biogeochemical cycling of elements
Lecture notesThe newly conceived lecture is supported by scripts.
LiteratureThe lecture is supported by scripts.
The lecture contains elements of "Brock Biology of Microorganisms", Madigan et al. 15th edition, Pearson und "Biochemistry" (Stryer), Berg et al. 9th edition, Macmillan international.
551-1106-00LProgress Reports in Microbiology and Immunology
Students must sign up via secr.micro.biol.ethz.ch
0 credits5SJ. Piel, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli
AbstractPresentation and discussion of current research results in the field of Microbiology and Infection Immunology
ObjectivePrecise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims
551-1109-00LSeminars in Microbiology0 credits2KS. Sunagawa, W.‑D. Hardt, M. Künzler, J. Piel, J. Vorholt-Zambelli
AbstractSeminars by invited speakers covering selected microbiology themes.
ObjectiveDiscussion of selected microbiology themes presented by invited speakers.
551-1129-00LUnderstanding and Engineering Microbial Metabolism Restricted registration - show details
Number of participants limited to 6.
The enrolment is done by the D-BIOL study administration.
6 credits7PJ. Vorholt-Zambelli
AbstractThis laboratory course has a focus on current research topics in our laboratory related to metabolic engineering, the general understanding of metabolism, and is partially focused on one carbon metabolism. Projects will be conducted in small groups.
ObjectiveThe course aims at introducing technologies to investigate bacterial metabolism and key principles of metabolic engineering. The main focus of this block course is on practical work and will familiarize participants with complementary approaches, in particular genetic, biochemical and analytical techniques including metabolomics. Results will be presented by students in scientific presentations. Another goal is to learn how to write a scientific report.
ContentThe course and will include topics such as pathway elucidation & engineering and related ongoing research projects in the lab. Experimental work applied during the course will comprise methods such as cloning work & transformation, growth determination, enzyme activity assays, liquid-chromatography mass-spectrometry and dynamic labeling experiments.
Lecture notesNone
LiteratureWill be provided at the beginning of the course.
752-4001-00LMicrobiology2 credits2VM. Ackermann, M. Schuppler, J. Vorholt-Zambelli
AbstractTeaching of basic knowledge in microbiology with main focus on Microbial Cell Structure and Function, Molecular Genetics, Microbial Growth, Metabolic Diversity, Phylogeny and Taxonomy, Prokaryotic Diversity, Human-Microbe Interactions, Biotechnology.
ObjectiveTeaching of basic knowledge in microbiology.
ContentDer Schwerpunkt liegt auf den Themen: Bakterielle Zellbiologie, Molekulare Genetik, Wachstumsphysiologie, Biochemische Diversität, Phylogenie und Taxonomie, Prokaryotische Vielfalt, Interaktion zwischen Menschen und Mikroorganismen sowie Biotechnologie.
Lecture notesWird von den jeweiligen Dozenten ausgegeben.
LiteratureDie Behandlung der Themen erfolgt auf der Basis des Lehrbuchs Brock, Biology of Microorganisms