Julia Vorholt-Zambelli: Catalogue data in Autumn Semester 2023 |
| Name | Prof. Dr. Julia Vorholt-Zambelli |
| Field | Mikrobiologie |
| Address | Institut für Mikrobiologie ETH Zürich, HCI F 429 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 632 55 24 |
| Fax | +41 44 633 13 07 |
| jvorholt@ethz.ch | |
| Department | Biology |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||
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| 551-0125-00L | Fundamentals of Biology I: From Molecules to the Biochemistry of Cells | 6 credits | 5G | J. Vorholt-Zambelli, N. Ban, R. Glockshuber, K. Locher, J. Piel | ||||||||||||||||||||||||||
| Abstract | The lecture provides an introduction to the basics of biochemistry and molecular biology as well as evolutionary principles. The focus is on bacteria and archaea under consideration of universal concepts. | |||||||||||||||||||||||||||||
| Learning objective | Introduction to biochemistry, molecular biology and evolutionary principles | |||||||||||||||||||||||||||||
| Content | The lecture introduces biology as an interdisciplinary science. Links to physics and chemistry will manifest as biological processes that operate within the laws of thermodynamics and are rooted in elements, molecules and chemical reactions. The transition from geochemistry to biochemistry is discussed and considered in relation to the origin of life. Evolutionary principles are introduced and resulting processes are used as a guiding principle. Unifying concepts in biology are presented, including the structure and function of cellular macromolecules and the ways in which hereditary information is encoded, decoded and replicated. Central principles of universal energy conversion are looked at, starting from redox processes and focusing on bacteria and archaea. Finally, biological processes are put into an ecosystems perspective. The lecture is divided into different sections: 1. Geochemical perspectives on Earth and introduction to evolution 2. Building blocks of life 3. Macromolecules: Proteins 4. Membranes and transport across the plasma membrane 5. Universal mechanisms of inheritance, transcription and translation 6. Reaction Kinetics, binding equilibria and enzymatic catalysis 7. Essentials of Catabolism 8. Essentials of Anabolism 9. Metabolism and biogeochemical cycling of elements | |||||||||||||||||||||||||||||
| Lecture notes | The newly conceived lecture is supported by scripts. | |||||||||||||||||||||||||||||
| Literature | The lecture is supported by scripts. The lecture contains elements of "Brock Biology of Microorganisms", Madigan et al. 15th edition, Pearson und "Biochemistry" (Stryer), Berg et al. 9th edition, Macmillan international. | |||||||||||||||||||||||||||||
Competencies |
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| 551-1106-00L | Progress Reports in Microbiology and Immunology Students must sign up via secr.micro.biol.ethz.ch | 0 credits | 5S | J. Piel, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli | ||||||||||||||||||||||||||
| Abstract | Presentation and discussion of current research results in the field of Microbiology and Infection Immunology | |||||||||||||||||||||||||||||
| Learning objective | Precise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims | |||||||||||||||||||||||||||||
| 551-1109-00L | Seminars in Microbiology | 0 credits | 2K | S. Sunagawa, W.‑D. Hardt, M. Künzler, J. Piel, J. Vorholt-Zambelli | ||||||||||||||||||||||||||
| Abstract | Seminars by invited speakers covering selected microbiology themes. | |||||||||||||||||||||||||||||
| Learning objective | Discussion of selected microbiology themes presented by invited speakers. | |||||||||||||||||||||||||||||
| 551-1129-00L | Understanding and Engineering Microbial Metabolism  Number of participants limited to 6. The enrolment is done by the D-BIOL study administration. | 6 credits | 7P | J. Vorholt-Zambelli | ||||||||||||||||||||||||||
| Abstract | The focus of this laboratory course is on current research topics related to metabolic engineering and the general understanding of metabolism, particularly in relation to one carbon metabolism. Projects will be carried out in small teams. | |||||||||||||||||||||||||||||
| Learning objective | The course aims at introducing technologies to investigate bacterial metabolism and key principles of metabolic engineering. The main focus of this block course is on practical work and will familiarize participants with complementary approaches, in particular genetic, biochemical and analytical techniques including metabolomics. Results will be presented by students in scientific presentations. Another goal is to learn how to write a scientific report. | |||||||||||||||||||||||||||||
| Content | The course and will include topics such as pathway elucidation & engineering and related ongoing research projects in the lab. Experimental work applied during the course will comprise methods such as cloning work & transformation, growth determination, enzyme activity assays, liquid-chromatography mass-spectrometry and dynamic labeling experiments. | |||||||||||||||||||||||||||||
| Lecture notes | None | |||||||||||||||||||||||||||||
| Literature | Will be provided at the beginning of the course. | |||||||||||||||||||||||||||||
| Competencies |
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