Christian Frei: Catalogue data in Spring Semester 2019

Name Dr. Christian Frei
Inst. f. Biomedizinische Technik
ETH Zürich, GLC F 12.2
Gloriastrasse 37/ 39
8092 Zürich
Telephone+41 44 632 45 85
DepartmentInformation Technology and Electrical Engineering

227-0945-10LCell and Molecular Biology for Engineers II
This course is part II of a two-semester course.
Knowledge of part I is required.
3 credits2GC. Frei
AbstractThe course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology.
ObjectiveAfter completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested.
ContentLectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells.

In addition, 4 journal clubs will be held, where recent publications will be discussed (2 journal clubs in part I and 2 journal clubs in part II). For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded and count as 40% for the final grade.
Lecture notesScripts of all lectures will be available.
Literature"Molecular Biology of the Cell" (6th edition) by Alberts, Johnson, Lewis, Morgan, Raff, Roberts, and Walter.
227-0949-10LBiological Methods for Engineers (Advanced Lab) Restricted registration - show details
Limited number of participants.
Students of the MSc in Biomedical Engineering have priority.
4 credits9PC. Frei
AbstractThe 2 week-long, full-time block course covers basic laboratory skills and safety, cell culture, protein analysis, RNA/DNA Isolation and RT-PCR. Each topic will be introduced, followed by practical work at the bench.
ObjectiveThe goal of this laboratory course is to give students practical exposure to basic techniques of cell and molecular biology.
ContentThe goal of this laboratory course is to give students practical exposure to basic techniques of cell and molecular biology.
Prerequisites / NoticeEnrollment is limited and preference given to students in the Masters of Biomedical Engineering program.
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
2 credits4RC. Frei
AbstractBasic knowledge of enzymology, in particular the structure, kinetics and chemistry of enzyme-catalysed reaction in vitro and in vivo. Biochemistry of metabolism: Those completing the course are able to describe and understand fundamental cellular metabolic processes.
ObjectiveIn this self-study course, the students will gain solid biochemical knowledge about enzymology, membrane biochemistry, and central metabolism.

Introduction, basics, composition of cells, biochemical units, repetition of relevant organic chemistry
Structure and function of proteins
Carbohydrates, structure of DNA
Lipids an biological membranes
Enzymes and enzyme kinetics
Catalytic strategies
Metabolism: Basic concepts and design. Repetition of basic thermodynamics
The citric acid cycle
Oxidative phosphorylation
Fatty acid metabolism
Lecture notesHorton et al. (Pearson) serves as lecture notes.
LiteratureHorton, Moran, Scrimgeour, Perry, Rawn: Principles of Biochemistry, 4th ed. or
Moran, Horton, Scrimgeour, Perry: Principles of Biochemistry, 5th ed.
Pearson Education Limited, Essex
Prerequisites / NoticeBasic knowledge in biology and chemistry is a precondition.