Paola Picotti: Catalogue data in Autumn Semester 2019

Name	Prof. Dr. Paola Picotti
Field	Molecular Systems Biology
Address	Inst. f. Molekulare Systembiologie ETH Zürich, HPM H 46 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND
Telephone	+41 44 633 25 58
Fax	+41 44 633 12 98
E-mail	picotti@imsb.biol.ethz.ch
Department	Biology
Relationship	Full Professor

Number	Title	ECTS	Hours	Lecturers
551-0319-00L	Cellular Biochemistry (Part I)	3 credits	2V	U. Kutay, Q. Feng, M. Peter, P. Picotti, K. Weis, I. Zemp
Abstract	Concepts and molecular mechanisms underlying the biochemistry of the cell, providing advanced insights into structure, function and regulation of individual cell components. Particular emphasis will be put on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes such as intracellular transport, cell division & growth, and cell migration.
Learning objective	The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterisation of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain the integration of different molecules and signaling pathways into complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, cell division and cell growth. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer.
Content	Structural and functional details of individual cell components, regulation of their interactions, and various aspects of the regulation and compartmentalisation of biochemical processes. Topics include: biophysical and electrical properties of membranes; viral membranes; structural and functional insights into intracellular transport and targeting; vesicular trafficking and phagocytosis; post-transcriptional regulation of gene expression.
Lecture notes	Scripts and additional material will be provided during the semester. Please contact Dr. Alicia Smith for assistance with the learning materials. (alicia.smith@bc.biol.ethz.ch)
Literature	Recommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Prerequisites / Notice	To attend this course the students must have a solid basic knowledge in chemistry, biochemistry and general biology. The course will be taught in English.
551-1303-00L	Cellular Biochemistry of Health and Disease Number of participants limited to 20.	4 credits	2S	V. Korkhov, Y. Barral, J. Fernandes de Matos, T. Ishikawa, R. Kroschewski, M. Peter, P. Picotti, A. E. Smith, B. Snijder, K. Weis
Abstract	During this Masters level seminar style course, students will explore current research topics in cellular biochemistry focused on the structure, function and regulation of selected cell components, and the consequences of dysregulation for pathologies.
Learning objective	Students will work with experts toward a critical analysis of cutting-edge research in the domain of cellular biochemistry, with emphasis on normal cellular processes and the consequences of their dysregulation. At the end of the course, students will be able to introduce, present, evaluate, critically discuss and write about recent scientific articles in the research area of cellular biochemistry.
Content	Guided by an expert in the field, students will engage in classical round-table style discussions of current literature with occasional frontal presentations. Students will alternate as discussion leaders throughout the semester, with the student leader responsible to briefly summarize key general knowledge and context of the assigned primary research paper. Together with the faculty expert, all students will participate in discussion of the primary paper, including the foundation of the biological question, specific questions addressed, key methods, key results, remaining gaps and research implications.
Literature	The literature will be provided during the course
Prerequisites / Notice	The course will be taught in English.