Ernst Hafen: Catalogue data in Spring Semester 2020 |
Name | Prof. em. Dr. Ernst Hafen |
Field | Molekulare Entwicklungsbiologie |
Address | Inst. f. Molekulare Systembiologie ETH Zürich, HPM H 29 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND |
hafen@imsb.biol.ethz.ch | |
URL | http://www.imsb.ethz.ch/researchgroup/hafene |
Department | Biology |
Relationship | Professor emeritus |
Number | Title | ECTS | Hours | Lecturers | |
---|---|---|---|---|---|
551-0016-AAL | Biology II Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 2 credits | 4R | M. Stoffel, E. Hafen | |
Abstract | The lecture course Biology II is a basic introductory course into biology for students who need to pass this course for admission to their MSc curriculum. | ||||
Learning objective | The objective of the lecture course Biology II is the understanding of form, function, and development of animals and of the basic underlying mechanisms. | ||||
Content | The following numbers of chapters refer to the text-book "Biology" (Campbell & Reece, 10th edition, 2015) on which the course is based. Chapters 1-4 are a basic prerequisite. The sections "Structure of the Cell" (Chapters 5-10, 12, 17) and "General Genetics" (Chapters 13-16, 18, 46) are covered by the lecture Biology I. 1. Genomes, DNA Technology, Genetic Basis of Development Chapter 19: Eukaryotic Genomes: Organization, Regulation, and Evolution Chapter 20: DNA Technology and Genomics Chapter 21: The Genetic Basis of Development 2. Form, Function, and Development of Animals I Chapter 40: Basic Principles of Animal Form and Function Chapter 41: Animal Nutrition Chapter 44: Osmoregulation and Excretion Chapter 47: Animal Development 3. Form, Function, and Develeopment of Animals II Chapter 42: Circulation and Gas Exchange Chapter 43: The Immune System Chapter 45: Hormones and the Endocrine System Chapter 48: Nervous Systems Chapter 49: Sensory and Motor Mechanisms | ||||
Literature | The following text-book is the basis for the courses Biology I and II: Biology, Campbell and Rees, 10th Edition, 2015, Pearson/Benjamin Cummings, ISBN 978-3-8632-6725-4 | ||||
Prerequisites / Notice | Prerequisite: Lecture course Biology I of winter semester | ||||
551-0016-00L | Biology II | 2 credits | 2V | M. Stoffel, E. Hafen, K. Köhler | |
Abstract | The lecture course Biology II, together with the course Biology I of the previous winter semester, is a basic introductory course into biology for students of materials sciences, of chemistry and of chemical engineering. | ||||
Learning objective | The objective of the lecture course Biology II is the understanding of form, function, and development of animals and of the basic underlying mechanisms. | ||||
Content | The following numbers of chapters refer to the text-book "Biology" (Campbell & Rees, 10th edition, 2015) on which the course is based. Chapters 1-4 are a basic prerequisite. The sections "Structure of the Cell" (Chapters 5-10, 12, 17) and "General Genetics" (Chapters 13-16, 18, 46) are covered by the lecture Biology I. 1. Genomes, DNA Technology, Genetic Basis of Development Chapter 19: Eukaryotic Genomes: Organization, Regulation, and Evolution Chapter 20: DNA Technology and Genomics Chapter 21: The Genetic Basis of Development 2. Form, Function, and Development of Animals I Chapter 40: Basic Principles of Animal Form and Function Chapter 41: Animal Nutrition Chapter 44: Osmoregulation and Excretion Chapter 47: Animal Development 3. Form, Function, and Develeopment of Animals II Chapter 42: Circulation and Gas Exchange Chapter 43: The Immune System Chapter 45: Hormones and the Endocrine System Chapter 48: Nervous Systems Chapter 49: Sensory and Motor Mechanisms | ||||
Lecture notes | The course follows closely the recommended text-book. Additional handouts may be provided by the lecturers. | ||||
Literature | The following text-book is the basis for the courses Biology I and II: Biology, Campbell and Rees, 10th Edition, 2015, Pearson/Benjamin Cummings, ISBN 978-3-8632-6725-4 | ||||
Prerequisites / Notice | Prerequisite: Lecture course Biology I of autumn semester | ||||
551-0103-AAL | Fundamentals of Biology II: Cell Biology Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 5 credits | 11R | U. Kutay, Y. Barral, E. Hafen, G. Schertler, U. Suter, S. Werner | |
Abstract | The goal of this course is to provide students with a wide general understanding in cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others. | ||||
Learning objective | The goal of this course is to provide students with a wide general understanding cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others. | ||||
Content | The focus is animal cells and the development of multicellular organisms with a clear emphasis on the molecular basis of cellular structures and phenomena. The topics include biological membranes, the cytoskeleton, protein sorting, energy metabolism, cell cycle and division, viruses, extracellular matrix, cell signaling, embryonic development and cancer research. | ||||
Literature | Alberts et al. 'Molecular Biology of the Cell' 6th edition, 2014, ISBN 9780815344322 (hard cover) and ISBN 9780815345244 (paperback). Topic/Lecturer/Chapter/Pages: Analyzing cells & molecules / Gebhard Schertler/8/ 439-463; Membrane structure / Gebhard Schertler/ 10/ 565-595; Compartments and Sorting/ Ulrike Kutay/12+14+6/641-694/755-758/782-783/315-320/325 -333/Table 6-2/Figure6-20, 6-21, 6-32, 6-34; Intracellular Membrane Traffic/ Ulrike Kutay/13/695-752; The Cytoskeleton/ Ulrike Kutay/ 16/889 - 948 (only the essentials); Membrane Transport of Small Molecules and the Electrical Properties of Membranes /Sabine Werner/11/597 - 633; Mechanisms of Cell Communication / Sabine Werner/15/813-876; Cancer/ Sabine Werner/20/1091-1141; Cell Junctions and Extracellular Matrix/Ueli Suter / 1035-1081; Stem Cells and Tissue Renewal/Ueli Suter /1217-1262; Development of Multicellular organisms/ Ernst Hafen/ 21/ 1145-1179 /1184-1198/1198-1213; Cell Migration/Joao Matos/951-960; Cell Death/Joao Matos/1021-1032; Cell Cycle/chromosome segregation/Cell division/Meiosis/Joao Matos/ 963-1018. | ||||
Prerequisites / Notice | none | ||||
551-0916-00L | Learning and Teaching Biology Does not take place this semester. Number of participants limited to 20 The block course will only take place with a minimum of 10 participants. The enrolment is done by the D-BIOL study administration. | 6 credits | 7G | E. Hafen, further lecturers | |
Abstract | This course represents an introduction to recent research into student learning on the conceptual foundations of modern biology, together with pedagogical methods associated with effective instruction and its valuation. Students will be involved in active research into conceptual and practical issues involved in biology education and methods to discover student preconceptions. | ||||
Learning objective | Provides an overview on student's learning and shows ways to make the classroom experience more engaging and effective for students. Students will learn to produce a research-based paper on a project they work on during the course. | ||||
Literature | The course is not taught by a particular book, but recommended literature (review articles and selected primary literature) will be provided during the course. See the introductory video to the course here: http://youtu.be/GFJuNncSsdE | ||||
551-0974-00L | Specialized Biology Course with an Educational Focus: Biological Concepts | 6 credits | 2G + 13A | E. Hafen, K. Köhler, H. Stocker | |
Abstract | Specialist aspects of biology with a focus on biological concepts and misconceptions are covered from the angle of imparting these to pupils, their historical development, and their significance for the subject, the individual and society. | ||||
Learning objective | After successful completion of the module, students should be able - to explain biological concepts and principles, as well as the way they fit together - to recognise and to correct existing misconceptions - to analyse controversial topics and to give factual explanations for these - to conduct more in-depth work on a research topic and to compile a tuition unit based on this topic - to prepare tuition units involving complex learning matter at a high specialist level which are suitably tailored to the recipients, and to teach these in a manner conducive to learning. | ||||
Content | Selected biological topics are dealt with under consideration of the special needs of persons involved in teaching. The module comprises lectures, a book club, and a seminar thesis. | ||||
Lecture notes | Teaching materials are available online on Moodle. | ||||
Literature | Literature and references are posted online on Moodle. | ||||
Prerequisites / Notice | The Specialized Biology Course with an Educational Focus consists of two modules (6 CP each). In the fall semester, the focus is on evolution. The module of the spring semester deals with biological concepts. Students attending both modules can start with either module. Performance is assessed during the course of the entire module. Active participation in the course is required. The electronic thesis and an oral presentation have to be completed. The Specialized Biology Course with an Educational Focus (6+6 CP) can be acknowledged, in agreement with the advisor of the respective elective major, as one of the two obligatory research projects (each 15 CP). In such a case, additional 3 CP must be obtained in another course. In case of overbooking of the course, students enrolled in the Teaching Diploma in Biology will have priority. | ||||
551-1298-00L | Genetics, Genomics, Bioinformatics | 4 credits | 2V + 2U | E. Hafen, C. Beyer, B. Christen, U. K. Genick, J. Piel, R. Schlapbach, G. Schwank, S. Sunagawa, K. Weis, A. Wutz | |
Abstract | The course provides the basis of modern genetics, genomics and bioinformatics. A special focus is placed on the use of these tools for the understanding of biological processes in bacteria, model organisms and humans. The unit uses the principle of blended learning consisting of self-study modules in Moodle, tasks and input lectures by experts from the department. | ||||
Learning objective | At the end of this course you know the most important genetic tools in different organisms. You can use the essential methods in bioinformatics by using online tools. You know the advantages and disadvantages of various model organisms to understand biological processes. You know the various mutagenesis methods and other tools to disrupt gene function and can discuss their merits and drawbacks. You are aware of the difficulties in choosing a phenotype for selection in a mutagenesis experiment. Finally, you can describe how you would study a specific biological process by choosing a model organism and the appropriate genetic or genomic tools. | ||||
Content | The appearance and function of an organism (phenotype) is determined by the interplay between its genome (genotype) and the environment: Genotype + environment = phenotype. Understanding these interactions to the point where we can ultimately predict the phenotype from knowledge of the genotype and environmental factors is one oft the great challenges of biology. In the course Bio IA you learnt about the composition and function of the genome and how it is inherited. The goal of this course is that you learn how genetic, genomic and bioinformatics methods are used to understand biological processes (the connection between genotype and phenotype). You will start by refreshing and deepening your knowledge of the basic principles of genetics and genomics in an interactive learning modules on the Moodle platform. This is followed by an introduction of the basic tools of bioinformatics and genomic analysis. After you have mastered the basic principles you will learn how to study biological processes either by inactivating specific genes or by randomly mutagenizing the entire genome. You will be introduced to different model organisms (bacteria, yeast, Drosophila) and humans. At the end of this first part of the course, you will test your knowledge by working with a group of fellow students to design your own genetic study. Conventional genetic methods rely on the alteration of the function of single genes and on the observation of the effect on the organism (phenotype). Based on the observed phenotype one deduces the normal function of the gene. However, this is a strong simplification. Even if environmental factors are controlled, phenotypes are very rarely controlled by a single gene. It is therefore important to understand the influence of the entire genome in conjunction with environmental factors on a given phenotype (e.g. human disease). Modern methods in genomics now permit first approaches in this direction. Therefore, the focus of the second part of the unit is on genomics methods. You learn, how the influence of the entire genome on a specific phenotype is detected and what challenges are involved in the analysis and the interpretation of the results. We will examine these methods in model organisms and humans. You will also learn how the genome of cancer cells changes under the constant selection for these cells to survive and how this genome analysis provides new insights into diagnosis and therapy. This course is based on active learning. Each week consists of a learning unit with clearly defined learning goals. In the first two hours you will learn the basics from texts, videos and questionnaires on the Moodle platform. In the third lecture an expert on the topic of the week (e.g. genetic screens in yeast) from the department will give an input lecture that builds on the basic knowledge that you acquired. In the fourth lecture you will discuss the tests and topics of the week with the expert. During the semester you will have access to assistants and lecturers via the Moodle online forum. | ||||
Lecture notes | The learning material and slides of the input lectures are available on Moodle. There you will also find further information (articles, links, videos). | ||||
Literature | All texts and references will be available on Moodle. To follow the most recent developments in this rapidly evolving field follow the following experts on Twitter: @dgmacarthur @EricTopol und/oder @ehafen | ||||
Prerequisites / Notice | The course builds on the course Bio IA, in particular on that course's content regarding genetics and genomics. The course is based on self-learning units on Moodle, input lectures by experts from D-BIOL and exercises. |