Michael Detmar: Catalogue data in Spring Semester 2021 |
| Name | Prof. em. Dr. Michael Detmar |
| Field | Pharmacogenomics |
| Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 303 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 73 61 |
| michael.detmar@pharma.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Professor emeritus |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 376-0008-00L | Advanced Physiology and Pathophysiology  Only for Health Sciences and Technology BSc. | 4 credits | 4V | K. De Bock, O. Bar-Nur, M. Detmar, G. A. Kuhn, M. Ristow, G. Schratt, C. Spengler, C. Wolfrum, M. Zenobi-Wong | |
| Abstract | In-depth theory to molecular and pathophysiological aspects of nerves, muscles, heart , circulatory , respiratory and sensory organs . | ||||
| Learning objective | In-depth knowledge of anatomy and physiology. | ||||
| Content | Molecular fundamentals of physiological processes, processes of disease development. | ||||
| Prerequisites / Notice | Language of teaching in this course is German/English depending on the teacher | ||||
| 535-0391-00L | Pathobiology | 4 credits | 3G | M. Detmar, V. I. Otto | |
| Abstract | Pathobiology describes the mechanisms underlying a disease and its clinical manifestations. An overview over important diseases of different organ systems and their symptoms will be given. How the discussed diseases can be recognized based on symptoms and diagnostic tests will be practiced based on case studies. | ||||
| Learning objective | Understanding of the molecular mechanisms that link the cause of a disease to its clinical manifestation. Knowing the most important diseases and their symptoms. First abilities to recognize and distinguish between different diseases based on case studies. | ||||
| Content | Lecture Topics: 1. Introduction and General Pathology 2. Diseases of Blood Cells 3. Cardiovascular Diseases 4. Lung Diseases 5. Kidney Diseases 6. Disorders of the Endocrine System 7. Metabolic Disorders 8. Gastrointestinal Diseases 9. Skin Diseases 10. Diseases of the Reproductive Organs 11. Diseases of the Bones and Joints 12. Disorders of the Central Nervous System 13. Disorders of Sensory Organs 14. Psychiatric Diseases Case studies referring to the diseases discussed in the course of the lectures will be solved and the solutions presented by the students. | ||||
| Lecture notes | Will be available at the following website: myStudies | ||||
| Literature | Kumar Vinay ; Abbas Abul K. ; Fausto Nelson ; Aster Jon C, Robbins and Cotran, Pathologic Basis of Disease, 9th ed., Saunders Elsevier, Philadelphia 2017 Mitchell Richard N. ; Kumar Vinay ; Abbas Abul K. ; Fausto Nelson ; Aster Jon C., Pocket Companion to Robbins and Cotran Pathologic Basis of Disease, 9th ed., Elsevier Saunders, Philadelphia 2017 Tischendorf Frank W. (Hrsg.), Blickdiagnostik : Compact-Atlas der klinischen Inspektion und Differenzialdiagnostik, 5. Aufl., Schattauer Verlag, Stuttgart 2017 | ||||
| Prerequisites / Notice | Requirements: Completion of Basic Studies | ||||
| 535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K.‑H. Altmann, M. Detmar, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer | |
| Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | ||||
| Learning objective | State-of-the-art information on drug discovery and development. | ||||
| Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | ||||
| 535-0901-00L | From A to Z in Drug Discovery and Development Does not take place this semester. | 2 credits | 2S | J. Hall, K.‑H. Altmann, M. Detmar, R. Schibli, H. U. Zeilhofer | |
| Abstract | The lecture series takes place at the ETH Hönggerberg and covers a variety of major activities involved in drug discovery: selecting drug targets, technologies used in drug discovery, small, medium and large drugs, objectives of the medicinal chemist, assessing drug safety, principles of personalized medicine, designing clinical trials, how intellectual property is protected, as well as others. | ||||
| Learning objective | The objective of the course is to gain a global understanding of most of the important phases in the discovery and development of modern synthetic and biological drugs, from the first activities to clinical trials. The lecture is intended for students that have an interest in the area and/or may consider a career working in drug discovery. This lecture course complements knowledge and experience gained in the research project performed by the PhD student. | ||||
| Content | Fifteen two hour lectures for life-science PhD students, given by experts from the ETH, UZH, USZ and the pharmaceutical industry. Introduction to the modern drug discovery process - Principles of drug pharmacokinetics and drug metabolism - Computer sciences in drug discovery - Drug targets - In vitro methods in drug discovery - Natural products in drug discovery - Medicinal chemistry: Chemical lead selection/optimization - Nucleic acid-based drugs - Antibodies and therapeutic proteins: Targets and drugs - In vivo molecular imaging in drug discovery - Personalized medicine in drug discovery and development - Drug formulation: Key development consideration, Current new APIs challenges and FDA rising standards - Preclinical safety, adverse drug events and drug-drug interactions - Clinical development steps including trial design - Intellectual property in drug discovery and development | ||||
| Lecture notes | Scripts to be uploaded into ILIAS | ||||
| Literature | To be distributed during the lecture | ||||
| Prerequisites / Notice | Formally none, but a basic understanding in biochemistry, physiology and chemistry is highly desirable as it will certainly help to get the most from the lectures. | ||||
| 551-0509-00L | Current Immunological Research in Zurich | 0 credits | 1K | R. Spörri, M. Detmar, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers | |
| Abstract | This monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion. | ||||
| Learning objective | The aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups. | ||||
| Content | Presentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich. | ||||
| Lecture notes | none | ||||