Michael Detmar: Catalogue data in Spring Semester 2020

Name Prof. em. Dr. Michael Detmar
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 303
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
Telephone+41 44 633 73 61
DepartmentChemistry and Applied Biosciences
RelationshipProfessor emeritus

376-0008-00LAdvanced Physiology and Pathophysiology Restricted registration - show details
Only for Health Sciences and Technology BSc.
4 credits4VK. De Bock, O. Bar-Nur, M. Detmar, G. A. Kuhn, M. Ristow, G. Schratt, C. Spengler, C. Wolfrum, M. Zenobi-Wong
AbstractIn-depth theory to molecular and pathophysiological aspects of nerves, muscles, heart , circulatory , respiratory and sensory organs .
ObjectiveIn-depth knowledge of anatomy and physiology.
ContentMolecular fundamentals of physiological processes, processes of disease development.
Prerequisites / NoticeLanguage of teaching in this course is German/English depending on the teacher
535-0391-00LPathobiology4 credits3GM. Detmar, V. I. Otto
AbstractPathobiology describes the mechanisms underlying a disease and its clinical manifestations. An overview over important diseases of different organ systems and their symptoms will be given. How the discussed diseases can be recognized based on symptoms and diagnostic tests will be practiced based on case studies.
ObjectiveUnderstanding of the molecular mechanisms that link the cause of a disease to its clinical manifestation. Knowing the most important diseases and their symptoms. First abilities to recognize and distinguish between different diseases based on case studies.
ContentLecture Topics:

1. Introduction and General Pathology

2. Diseases of Blood Cells

3. Kidney Diseases

4. Cardiovascular Diseases

5. Lung Diseases

6. Gastrointestinal Diseases

7. Disorders of the Endocrine System

8. Metabolic Disorders

9. Skin Diseases

10. Diseases of the Reproductive Organs

11. Diseases of the Bones and Joints

12. Disorders of the Central Nervous System

13. Disorders of Sensory Organs

14. Psychiatric Diseases

Case studies referring to the diseases discussed in the course of the lectures will be solved and the solutions presented by the students.
Lecture notesWill be available at the following website:

LiteratureKumar Vinay ; Abbas Abul K. ; Fausto Nelson ; Aster Jon C, Robbins and Cotran Pathologic Basis of Disease, 9th ed., Saunders Elsevier, Philadelphia 2015
Mitchell Richard N. ; Kumar Vinay ; Abbas Abul K. ; Fausto Nelson ; Aster Jon C., Pocket Companion to Robbins and Cotran Pathologic Basis of Disease, 9th ed., Elsevier Saunders, Philadelphia 2017
Tischendorf Frank W. (Hrsg.), Blickdiagnostik : Compact-Atlas der klinischen Inspektion und Differenzialdiagnostik, 5. Aufl., Schattauer Verlag, Stuttgart 2017
Prerequisites / NoticeRequirements: Completion of Basic Studies
535-0900-00LSeminars on Drug Discovery and Development1 credit1KR. Schibli, K.‑H. Altmann, M. Detmar, C. Halin Winter, J. Hall, J.‑C. Leroux, D. Neri, U. Quitterer, G. Schneider, H. U. Zeilhofer
AbstractState-of-the-art information on drug discovery and development by experts from academia and industry.
ObjectiveState-of-the-art information on drug discovery and development.
ContentSeminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics.
535-0901-00LFrom A to Z in Drug Discovery and Development
Does not take place this semester.
2 credits2SJ. Hall, K.‑H. Altmann, M. Detmar, D. Neri, R. Schibli, H. U. Zeilhofer
AbstractThe lecture series takes place at the ETH Hönggerberg and covers a variety of major activities involved in drug discovery: selecting drug targets, technologies used in drug discovery, small, medium and large drugs, objectives of the medicinal chemist, assessing drug safety, principles of personalized medicine, designing clinical trials, how intellectual property is protected, as well as others.
ObjectiveThe objective of the course is to gain a global understanding of most of the important phases in the discovery and development of modern synthetic and biological drugs, from the first activities to clinical trials. The lecture is intended for students that have an interest in the area and/or may consider a career working in drug discovery. This lecture course complements knowledge and experience gained in the research project performed by the PhD student.
ContentFifteen two hour lectures for life-science PhD students, given by experts from the ETH, UZH, USZ and the pharmaceutical industry.
Introduction to the modern drug discovery process - Principles of drug pharmacokinetics and drug metabolism - Computer sciences in drug discovery - Drug targets - In vitro methods in drug discovery - Natural products in drug discovery - Medicinal chemistry: Chemical lead selection/optimization - Nucleic acid-based drugs - Antibodies and therapeutic proteins: Targets and drugs - In vivo molecular imaging in drug discovery - Personalized medicine in drug discovery and development - Drug formulation: Key development consideration, Current new APIs challenges and FDA rising standards - Preclinical safety, adverse drug events and drug-drug interactions - Clinical development steps including trial design - Intellectual property in drug discovery and development
Lecture notesScripts to be uploaded into ILIAS
LiteratureTo be distributed during the lecture
Prerequisites / NoticeFormally none, but a basic understanding in biochemistry, physiology and chemistry is highly desirable as it will certainly help to get the most from the lectures.
551-0509-00LCurrent Immunological Research in Zürich0 creditsR. Spörri, M. Detmar, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers
AbstractThis monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion.
ObjectiveThe aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups.
ContentPresentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich.
Lecture notesnone