Marcy Zenobi-Wong: Katalogdaten im Frühjahrssemester 2019 |
| Name | Frau Prof. Dr. Marcy Zenobi-Wong |
| Lehrgebiet | Knorpeltechnologie und -regeneration |
| Adresse | Gewebetechnol. und Biofabrikation ETH Zürich, HPL J 22 Otto-Stern-Weg 7 8093 Zürich SWITZERLAND |
| Telefon | +41 44 632 50 89 |
| marcy.zenobi@hest.ethz.ch | |
| URL | https://biofabrication.ethz.ch/ |
| Departement | Gesundheitswissenschaften und Technologie |
| Beziehung | Ordentliche Professorin |
| Nummer | Titel | ECTS | Umfang | Dozierende | |
|---|---|---|---|---|---|
| 376-0008-00L | Vertiefung Anatomie und Physiologie II: Vertiefung Physiologie und Pathophysiologie  Nur für Gesundheitswissenschaften und Technologie BSc. | 4 KP | 4V | K. De Bock, O. Bar-Nur, M. Detmar, G. A. Kuhn, M. Ristow, G. Schratt, C. Spengler, C. Wolfrum, M. Zenobi-Wong | |
| Kurzbeschreibung | Vertiefende Theorie zu molekularen und pathophysiologischen Aspekten von Nerven, Muskeln, Herz, Kreislauf, Atmung und Sinnesorganen. | ||||
| Lernziel | Vertiefendes Wissen über Anatomie und Physiologie. | ||||
| Inhalt | Molekulare Grundlagen von physiologischen Prozessen, Prozesse der Krankheitsentwicklung. | ||||
| 376-1392-00L | Mechanobiology: Implications for Development, Regeneration and Tissue Engineering | 3 KP | 2G | A. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong | |
| Kurzbeschreibung | This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs. | ||||
| Lernziel | This course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena. | ||||
| Inhalt | Typically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include osteogenesis (bones), chondrogenesis (cartilage), and tendogenesis (tendons). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance. The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering. | ||||
| Skript | n/a | ||||
| Literatur | Topical Scientific Manuscripts | ||||
| 376-1614-00L | Principles in Tissue Engineering | 3 KP | 2V | K. Maniura, J. Möller, M. Zenobi-Wong | |
| Kurzbeschreibung | Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | ||||
| Lernziel | Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed. | ||||
| Inhalt | This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | ||||
| Skript | Handouts provided during the classes and references therin. | ||||
| Literatur | The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002 | ||||
| 376-1624-00L | Practical Methods in Biofabrication Number of participants limited to 12. | 5 KP | 4P | M. Zenobi-Wong, S. Schürle-Finke, K. Würtz-Kozak | |
| Kurzbeschreibung | Biofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft. | ||||
| Lernziel | The objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based project. | ||||
| Voraussetzungen / Besonderes | Not recommended if passed 376-1622-00 Practical Methods in Tissue Engineering | ||||
| 376-1974-00L | Colloquium in Biomechanics  | 2 KP | 2K | B. Helgason, S. J. Ferguson, R. Müller, J. G. Snedeker, W. R. Taylor, K. Würtz-Kozak, M. Zenobi-Wong | |
| Kurzbeschreibung | Current topics in biomechanics presented by speakers from academia and industry. | ||||
| Lernziel | Getting insight into actual areas and problems of biomechanics. | ||||