Rudolf Aebersold: Catalogue data in Spring Semester 2018

Name Prof. Dr. Rudolf Aebersold
FieldSystembiologie
E-mailaebersold@imsb.biol.ethz.ch
DepartmentBiology
RelationshipProfessor emeritus

NumberTitleECTSHoursLecturers
551-0002-00LGeneral Biology II Restricted registration - show details 4 credits4GU. Sauer, R. Aebersold, W. Gruissem
AbstractBasics of biochemistry (macromolecules, membranes, cellular structures, metabolism), molecular genetics (gene expression and its regulation; from gene to protein), and physiology of higher plants (structure, growth, development, nutrition, transport, reproduction)
ObjectiveThe understanding of basic concepts of molecular biology and physiology.
ContentHow cells function at the level of molecules and higher structures.
Molecular processes during gene expression.
Plant physiology.

The following Campbell chapters will be covered:

Week 1-5: Prof. Sauer
5 Biological macromolecules and lipids
7 Cell structure and function
8 Cell membranes
10 Respiration: introduction to metabolism
10 Cell respiration
11 Photosynthetic processes

Week 6-9: Prof. Aebersold
16 Nucleic acids and inheritance
17 Expression of genes
18 Control of gene expression
19 DNA Technology

Week 9-13: Prof. Gruissem
35 Plant Structure and Growth
36 Transport in vascular plants
37 Plant nutrition
38 Reproduction of flowering plants
39 Plants signal and behavior
Lecture notesNo script
LiteratureCampbell, Reece et al: "Biologie" (10th global edition); Pearson 2015.
551-0003-AALGeneral Biology I+II
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
7 credits13RU. Sauer, R. Aebersold, W. Gruissem, O. Y. Martin, A. Widmer
AbstractGeneral Biology I: Organismic biology to teach the basic principles of classical and molecular genetics, evolutionary biology and phylogeny.

General Biology II: Molecular biology approach to teach the basic principles of biochemistry, cell biology, cgenetics, evolutionary biology and form and function of vacular plants.
ObjectiveGeneral Biology I: The understanding of basic principles of biology (inheritance, evolution and phylogeny) and an overview of the diversity of life.

General Biology II: The understanding basic concepts of biology: the hierarchy of the structural levels of biological organisation, with particular emphasis on the cell and its molecular functions, the fundamentals of metabolism and molecular genetics, as well as form and function of vascular plants.
ContentGeneral Biology I:
General Biology I focuses on the organismal biology aspects of genetics, evolution and diversity of life in the Campbell chapters 12-34.

Week 1-7 by Alex Widmer, Chapters 12-25
12 Cell biology Mitosis
13 Genetics Sexual life cycles and meiosis
14 Genetics Mendelian genetics
15 Genetics Linkage and chromosomes
20 Genetics Evolution of genomes
21 Evolution How evolution works
22 Evolution Phylogentic reconstructions
23 Evolution Microevolution
24 Evolution Species and speciation
25 Evolution Macroevolution

Week 8-14 by Oliver Martin, Chapters 26-34
26 Diversity of Life Introdution to viruses
27 Diversity of Life Prokaryotes
28 Diversity of Life Origin & evolution of eukaryotes
29 Diversity of Life Nonvascular&seedless vascular plants
30 Diversity of Life Seed plants
31 Diversity of Life Introduction to fungi
32 Diversity of Life Overview of animal diversity
33 Diversity of Life Introduction to invertebrates
34 Diversity of Life Origin & evolution of vertebrates


General Biology II: The structure and function of biomacromolecules; basics of metabolism; tour of the cell; membrane structure and function; basic energetics of cellular processes; respiration, photosynthesis; cell cycle, from gene to protein; structure and growth of vascular plants, resource acquisition and transport, soil and plant nutrition.

Specifically the following Campbell chapters will be covered:
3 Biochemistry Chemistry of water
4 Biochemistry Carbon: the basis of molecular diversity
5 Biochemistry Biological macromolecules and lipids
7 Cell biology Cell structure and function
8 Cell biology Cell membranes
10 Cell biology Respiration: introduction to metabolism
10 Cell biology Cell respiration
11 Cell biology Photosynthetic processes
16 Genetics Nucleic acids and inheritance
17 Genetics Expression of genes
18 Genetics Control of gene expression
19 Genetics DNA Technology
35 Plant structure&function Plant Structure and Growth
36 Plant structure&function Transport in vascular plants
37 Plant structure&function Plant nutrition
38 Plant structure&function Reproduction of flowering plants
39 Plant structure&function Plants signal and behavior
Lecture notesNo script
LiteratureCampbell et al. (2015) Biology - A Global Approach. 10th Edition (Global Edition)
Prerequisites / NoticeBasic general and organic chemistry


This is a virtual self-study lecture for non-German speakers of the "Allgemeine Biology I (551-0001-00L) and "Allgemeine Biology II (551-0002-00L) lectures. The exam will be written jointly with the participants of this lecture.
551-0224-00LAdvanced Proteomics Restricted registration - show details
For master students from the 2nd semester on, also doctoral candidates and post docs.
4 credits6GR. Aebersold, L. Gillet, M. Gstaiger, A. Leitner, P. Pedrioli
AbstractGoal of the course is to analyze current and newly emerging technologies and approaches in protein and proteome analysis with regard to their application in biology, biotechnology and medicine.
Format: Introduction by instructor followed by discussions stimulated by reading assignments and exercises.
ObjectiveTo discuss current and newly emerging technologies and approaches in protein and proteome analysis with regard to their applications in biology, biotechnology, medicine and systems biology.
ContentBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Prerequisites / NoticeNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students http://www.rektorat.ethz.ch/students/admission/auditors/index_EN
551-0324-00LSystems Biology6 credits4VR. Aebersold, B. Christen, M. Claassen, U. Sauer
AbstractIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Objective- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
ContentOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Lecture notesno script
LiteratureThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005