Karl-Heinz Altmann: Catalogue data in Autumn Semester 2020

Name Prof. em. Dr. Karl-Heinz Altmann
FieldPharmazeutische Biologie
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 405
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
DepartmentChemistry and Applied Biosciences
RelationshipProfessor emeritus

511-0000-00LDrug Discovery and Development Restricted registration - show details
Only for Pharmaceutical Sciences MSc.
2 credits2GU. Thibaut, K.‑H. Altmann, J. Hall, J.‑C. Leroux, J. Scheuermann, G. Schneider
AbstractThis course provides an overview over the concepts and processes employed in today's drug discovery and development. It has an introductory character but will also provide more detailed insights employing real life examples. The course combines lectures and interactive elements with active participation of the students.
- Understand the drug discovery process and can explain major approaches and relevant technical terms (for details see lecture notes).
- Understand and appreciate the content and timing of drug development process steps, development phases and decision criteria.
- Understand the concepts underlying drug product development through all the phases from preclinical and clinical development to regulatory submission, approval and market launch.
- Can differentiate between small molecule drug development and biological drug development.
- Understand the most important differences between legal and regulatory requirements for drug development and approval for the major markets EU and USA.
ContentDrug Discovery (day 1):

Introduction to drug discovery: the concepts of drug target selection, ligands/leads, the developability of drug candidates;
Overview over the principal approaches to drug discovery: rational drug design, the natural product approach, serendipity, repurposing as well as chemical libraries and high-throughput screening.

Drug Development (day 2)

Introduction to development processes from the perspective of the pharmaceutical industry. Why and how are decisions for drug development candidates made? What drives portfolio decisions of pharmaceutical companies? Besides stimulating lectures, the course also includes group work on interesting new drugs both from the class of small molecules as well as from biologicals.

Drug Development (days 3 and 4):

Introduction to the entire suite of drug product development processes in the pharmaceutical industry, covering the following phases: preclinical research and development, clinical development, regulatory processes and market launch.
R&D support processes such as project management, quality management, pharmacovigilance and pharmacoeconomics will be covered as well as organizational and governance aspects of the pharmaceutical industry.
In addition, important success factors for a later career in the pharmaceutical industry will be discussed and highlighted at the end of the course.
Lecture notesWill be published on "mystudies"
LiteratureG. Nahler (Hrsg.) Dictionary of pharmaceutical medicine, Springer, Wien, 2013 (3rd edition)
Further readings will be listed in the lecture notes.
Prerequisites / NoticeThis course provides the essential basic knowledge required for the industry-specific modules of the spring semester.

Schutzkonzept: https://chab.ethz.ch/studium/bachelor1.html
535-0001-00LIntroduction to Pharmaceutical Sciences I2 credits2VJ. Hall, K.‑H. Altmann, A. Burden, M. Detmar, C. Halin Winter, J.‑C. Leroux, C. Müller, U. Quitterer, J. Scheuermann, R. Schibli, G. Schneider, H. U. Zeilhofer
AbstractFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ObjectiveFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ContentIntroduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields.
Lecture notesHandouts for individual lectures.
Prerequisites / NoticeInteractive teaching
535-0011-00LDrug Seminar Restricted registration - show details
The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences
5 credits9SK. Eyer, K.‑H. Altmann, S. M. Ametamey, A. Burden, M. Detmar, C. Halin Winter, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, V. I. Otto, U. Quitterer, R. Schibli, G. Schneider, C. Steuer
AbstractThe course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium.
ObjectiveThe main objectives of this course are:

- students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic
- students gain in-depth knowledge of the topic investigated
- students train their scientific writing and presentation skills
- students train their ability to plan a project and work in a team
ContentThe Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences.

The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences.

During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester.
Prerequisites / NoticeOnly for students of MSc Pharmacy and MSc Pharmaceutical Sciences.
535-0333-00LPharmaceutical Biology3 credits2VK.‑H. Altmann
AbstractThe structure and biosynthesis of plant constituents and the pharmacological effects and therapeutic applications of biogenic drugs of plant origin (extract-based herbal medicines; isolated natural products) are discussed. Areas of focus are (a) major biosynthetic pathways for plant-derived natural products, (b) pharmacological effects of herbal extracts, and (c) molecular mechanisms of action.
ObjectiveThe understanding of the biosynthesis of plant-derived natural products. Acquisition of fundamental knowledge on the medical applications of important herbal medicines and of isolated natural products (general disease areas, molecular constituents of medicinal plants and herbal medicines in general, molecular constituents responsible for pharmacological activity, possible mechanisms of action, available clinical data to support medical use).
ContentThe lecture is centered around the discussion of medicinal plants and herbal medicines and their common medical applications. The main areas addressed in the lecture are (a) the structure and biosynthesis of plant constituents (i.e. plant-derived natural products) and (b) the pharmacological effects and therapeutic applications of biogenic drugs of plant origin (herbal medicines based on plant extracts as well as isolated natural products). The basic pathways for the biosynthesis of the most important classes of plant-derived natural products are discussed in detail. Likewise, the molecular basis of the pharmacological effects of medicinal plant extracts (and derived herbal medicines) and their individual constituent components (isolated natural products) is broadly addressed. As part of this discussion the availability of clinical data (or lack thereof) to support specific clinical applications of herbal medicines will be repeatedly highlighted. Potential risks associated with the use of herbal medicines are discussed for selected cases.
The lecture is structured according to the major classes of natural products prevalent in medicinal plants and herbal medicines: Carbohydrates, lipids, terpenes, phenolic compounds, alkaloids, essential oils.
Lecture notesIs provided in parts before each lecture (electronically as pdf) and also available on the Ilias platform via My Studies.
Literature- There is no English translation of the above textbook (or any reasonably equivalent text). Students intending to take the exam for the course and are not sufficiently proficient in German should contact the lecturer before the start of the course.
Prerequisites / NoticeRequirements: Lecture courses in basic organic chemistry, biochemistry, and biology
535-0900-00LSeminars on Drug Discovery and Development1 credit1KR. Schibli, K.‑H. Altmann, S. M. Ametamey, M. Detmar, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer
AbstractState-of-the-art information on drug discovery and development by experts from academia and industry.
ObjectiveState-of-the-art information on drug discovery and development.
ContentSeminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics.
535-1001-00LLaboratory Course General Chemistry (for Biology and Pharmacy) Restricted registration - show details
Information about the practical course will be given on the first day.
6 credits8PS. Gruber, K.‑H. Altmann, J. Hall
AbstractIntroduction to the practical work in a chemistry laboratory. The most important manipulations and techniques are treated, as well as the most fundamental chemical reaction types.
Objective- Knowledge of the basic chemical laboratory methods
- Basic knowledge of the scientific approach in experimenting
- Observation and interpretation of chemical processes
- Keeping of a reliable laboratory journal
Content- Simple chemical working techniques/methods
- Separation techniques
- Physical measurements: mass, volume, pH
- Ionic solids (salts)
- Acid/base chemistry, buffers
- Redox reactions
- Metal complexes
- Titration methods and quantitative spectrometry
- Introduction to qualitative analysis
Lecture notesCourse manual in German (is handed out to the students at the begin of the lessons)
Language: German, English upon request
LiteratureBasic Concepts of Chemistry, International Student Version, 8th Edition, Leo J. Malone, Theodore Dolter

is a suitable textbook.
Prerequisites / NoticeThis practical course causes costs for materials and chemicals. The costs are charged to the students at the end of semester.