Karl-Heinz Altmann: Catalogue data in Autumn Semester 2019 |
| Name | Prof. em. Dr. Karl-Heinz Altmann |
| Field | Pharmazeutische Biologie |
| Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 405 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| karl-heinz.altmann@pharma.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Professor emeritus |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 529-5000-00L | Chemistry (for Medical Students)  Only for Human Medicine BSc | 4 credits | 3V + 1U | K.‑H. Altmann, S. Wolfrum | |
| Abstract | The lecture teaches the most important fundamental concepts in chemistry (atomic structure, chemical bonds, thermodynamics and kinetics of chemical reactions, acid-base equilibria, types and reactivity of organic compounds, stereochemistry, biomolecules). Connections of chemical processes with medically important biochemical, physiological, and pharmacological questions are highlighted. | ||||
| Learning objective | Understanding of the basic concepts of chemistry. Understanding the importance of chemical processes in human physiology and in the diagnosis and treatment of human disease. | ||||
| Content | The lecture elaborates the fundamental concepts of chemistry. The organization of the lecture is guided by the two textbooks "Chemie für Mediziner" by Zeeck et al. and Schmuck et al., respectively, referred to below. Accordingly, the following major subject areas will be covered: Atomic structure, periodic table of the elements, types of chemical bonds, states of matter, heterogeneous equilibria, thermodynamics and kinetics of chemical reactions, salt solutions, acids and bases, oxidation and reduction, metal complexes, fundamentals of organic chemistry, important classes of organic compounds and their reactivities, stereochemistry, amino acids and peptides, carbohydrates, lipids, heterocycles, spectroscopy in chemistry and medicine. | ||||
| Lecture notes | Scripts for individual subject areas will be provided electronically prior to the corresponding lectures. | ||||
| Literature | There are no English translations of these textbooks. | ||||
| Prerequisites / Notice | There are no specific requirements. | ||||
| 535-0001-00L | Introduction to Pharmaceutical Sciences I | 2 credits | 2V | J. Hall, K.‑H. Altmann, A. Burden, M. Detmar, B. A. Gander, C. Halin Winter, J.‑C. Leroux, C. Müller, D. Neri, U. Quitterer, R. Schibli, G. Schneider, H. U. Zeilhofer | |
| Abstract | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
| Learning objective | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
| Content | Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields. | ||||
| Lecture notes | Handouts for individual lectures. | ||||
| Prerequisites / Notice | Interactive teaching | ||||
| 535-0011-00L | Drug Seminar The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences | 5 credits | 9S | U. Quitterer, K.‑H. Altmann, S. M. Ametamey, A. Burden, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, D. Neri, V. I. Otto, R. Schibli, G. Schneider, C. Steuer | |
| Abstract | The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium. | ||||
| Learning objective | The main objectives of this course are: - students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic - students gain in-depth knowledge of the topic investigated - students train their scientific writing and presentation skills - students train their ability to plan a project and work in a team | ||||
| Content | The Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences. The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester. | ||||
| Prerequisites / Notice | Only for students of MSc Pharmacy and MSc Pharmaceutical Sciences. | ||||
| 535-0333-00L | Pharmaceutical Biology | 3 credits | 2V | K.‑H. Altmann | |
| Abstract | The structure and biosynthesis of plant constituents and the pharmacological effects and therapeutic applications of biogenic drugs of plant origin (extract-based herbal medicines; isolated natural products) are discussed. Areas of focus are (a) major biosynthetic pathways for plant-derived natural products, (b) pharmacological effects of herbal extracts, and (c) molecular mechanisms of action. | ||||
| Learning objective | The understanding of the biosynthesis of plant-derived natural products. Acquisition of fundamental knowledge on the medical applications of important herbal medicines and of isolated natural products (general disease areas, molecular constituents of medicinal plants and herbal medicines in general, molecular constituents responsible for pharmacological activity, possible mechanisms of action, available clinical data to support medical use). | ||||
| Content | The lecture is centered around the discussion of medicinal plants and herbal medicines and their common medical applications. The main areas addressed in the lecture are (a) the structure and biosynthesis of plant constituents (i.e. plant-derived natural products) and (b) the pharmacological effects and therapeutic applications of biogenic drugs of plant origin (herbal medicines based on plant extracts as well as isolated natural products). The basic pathways for the biosynthesis of the most important classes of plant-derived natural products are discussed in detail. Likewise, the molecular basis of the pharmacological effects of medicinal plant extracts (and derived herbal medicines) and their individual constituent components (isolated natural products) is broadly addressed. As part of this discussion the availability of clinical data (or lack thereof) to support specific clinical applications of herbal medicines will be repeatedly highlighted. Potential risks associated with the use of herbal medicines are discussed for selected cases. The lecture is structured according to the major classes of natural products prevalent in medicinal plants and herbal medicines: Carbohydrates, lipids, terpenes, phenolic compounds, alkaloids, essential oils. | ||||
| Lecture notes | Is provided in parts before each lecture (electronically as pdf) and also available on the Ilias platform via My Studies. | ||||
| Literature | - There is no English translation of the above textbook (or any reasonably equivalent text). Students intending to take the exam for the course and are not sufficiently proficient in German should contact the lecturer before the start of the course. | ||||
| Prerequisites / Notice | Requirements: Lecture courses in basic organic chemistry, biochemistry, and biology | ||||
| 535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, J.‑C. Leroux, D. Neri, U. Quitterer, G. Schneider, H. U. Zeilhofer | |
| Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | ||||
| Learning objective | State-of-the-art information on drug discovery and development. | ||||
| Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | ||||
| 535-1001-00L | Laboratory Course General Chemistry (for Biology and Pharmacy)  Information about the practical course will be given on the first day. | 6 credits | 8P | R. O. Kissner, K.‑H. Altmann, J. Hall, D. Neri, M. D. Wörle | |
| Abstract | Introduction to the practical work in a chemistry laboratory. The most important manipulations and techniques are treated, as well as the the most fundamental chemical reaction types. | ||||
| Learning objective | - Knowledge of the basic chemical laboratory methods. - Basic knowledge of the scientific approach in experimenting. - Observation and interpretation of real-world chemical processes. - Keeping of a reliable laboratory journal. | ||||
| Content | - Simple chemical methods and calculations. - Separation techniques. - Physical measurements: mass, volume, pH, optical spectra. - Ionic solids (salts). - Acid/base chemistry, buffers. - Redox reactions. - Metal complexes. - Titration methods and quantitative spectrometry. - Introduction to qualitative analysis. | ||||
| Lecture notes | Course manual in German (is handed out to the students at the begin of the lessons). Language: German, English upon request. PDF files available at http://acac1.ethz.ch/praktikum/docs.html Accessible in intranet, by WLAN after login or through VPN | ||||
| Literature | Basic Concepts of Chemistry, International Student Version, 8th Edition, Leo J. Malone, Theodore Dolter Wiley is a suitable textbook. | ||||
| Prerequisites / Notice | This practical course causes costs for materials and chemicals. The costs are charged to the students at the end of semester. | ||||