Annette Oxenius: Catalogue data in Spring Semester 2022

Award: The Golden Owl
Name Prof. Dr. Annette Oxenius
Institut für Mikrobiologie
ETH Zürich, HCI G 401
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
Telephone+41 44 632 33 17
RelationshipFull Professor

551-0318-00LImmunology II3 credits2VA. Oxenius, M. Kopf, S. R. Leibundgut, E. Slack, further lecturers
AbstractIntroduction into the cellular and molecular basis of the immune system and immune responses against diverse pathogens, tumors, transplants, and self (autoimmunity)
ObjectiveThe lectures will provide a detailed understanding:
- how innate and adaptive immune responses interact at the cellular and molecular level.
- how the immune system recognizes and fights against pathogenic microorganisms including viruses, bacteria, and parasites.
- why lymphocytes tolerate self molecules.
- about function and dysfunction the intestinal immune system.
- immunopathology and inflammatory diseases.
ContentThe aim of lecture is to understand:
> How pathogens are recognized by the innate immune system
> Immune defense against various pathogens
> Immunology of the skin, lung and intestines
> Tumor immunology
> Migration and homing of immune cells
> tolerance and autoimmunity
> T cell memory
Lecture notesPresentations of the lecturers are available at the Moodle link
LiteratureRecommended: Kuby Immunology (Freeman)
551-0396-01LImmunology I Restricted registration - show details
Number of participants limited to 30.

Prerequisites: Attendance of the concept courses Immunology I (551-0317-00L) and Immunology II (551-0318-00L)

The enrolment is done by the D-BIOL study administration.
6 credits7PA. Oxenius, B. Becher, M. Groettrup, M. Kopf, B. Ludewig, C. Münz, R. Spörri, M. van den Broek
AbstractThis block course teaches a wide selection of practical immunological techniques and offers advanced lectures in selected topics in immunology.
ObjectiveThe aim of this block course is the acquaintance with a wide spectrum of immunological techniques involving practical experimental work following analysis and interpretation of the experimental data. Along the practical work, advanced lectures in selected topics in immunology, based on the knowledge from the immunology concept course, will be offered. Furthermore, students will have the opportunity to read, interpret and present current papers followed scientific discussions.
ContentPraktische Arbeiten: Zellkultur, Isolation hämatopoietische Stammzellen und Differenzierung von Makrophagen und dendritischen Zellen, Aktivierung und Zytokinproduktion durch Makrophagen und dendritische Zellen, 51Cr release assay, VSV Neutralisationsassay, Durchflusszytometrie, Proliferationsexperimente, SEREX, Intrazelluläres Zytokinstaining, Immunhistologie und Fluoreszenzmikroskopie, MACS, Zytokin-Bioassays, Phagozytose, Proteosomale Prozessierung
Vertiefende Vorlesungen: Immune responses to pathogens, Vaccination and B cells, Tolerance & Autoimmunity, Antigen processing & presentation, Pattern recognition, NK cells, Generation of (TCR) tg or ko mice, Antigen screening and definition
Lecture notesA script for the course will be available online (the link will be provided in the immunology concept lecture, 551-0318-00L).
Prerequisites / NoticeRequirement for the registration for this block course is the attendance of the immunology concept courses 551-0317-00L and 551-0318-00L.
Evaluation of achievements is done on an individual basis by each participating lecturer.
551-0509-00LCurrent Immunological Research in Zurich0 credits1KR. Spörri, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers
AbstractThis monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion.
ObjectiveThe aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups.
ContentPresentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich.
Lecture notesnone
551-1100-00LInfectious Agents: From Molecular Biology to Disease
Number of participants limited to 22.

Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures.
(if you missed the deadline, please come to the first date to see, if there are any slots left)
4 credits2SW.‑D. Hardt, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander, further lecturers
AbstractLiterature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.
ObjectiveWorking with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.
Contentfor each model pathogen (or key technology):
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
Lecture notesTeachers will provide the research papers to be discussed.
Students will prepare handouts for the rest of the group for their assigned seminar.
LiteratureTeachers will provide the research papers to be discussed.
Prerequisites / NoticeRestricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.
The first seminar date will serve to form groups of students and assign a paper to each group.
551-1106-00LProgress Reports in Microbiology and Immunology
Students must sign up via
0 credits5SJ. Piel, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli
AbstractPresentation and discussion of current research results in the field of Microbiology and Infection Immunology
ObjectivePrecise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims
551-1118-00LCutting Edge Topics: Immunology and Infection Biology II Information 2 credits2SA. Oxenius, B. Becher, C. Halin Winter, N. C. Joller, M. Kopf, S. R. Leibundgut, C. Münz, F. Sallusto, R. Spörri, M. van den Broek, University lecturers
AbstractWeekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion.
ObjectiveWeekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion.
The aim of this course is to confront students with current research topics and with scientific presentation. The course offers the opportunity to gain in depth knowledge about diverse topics which are often only briefly touched in the concept courses and to engage in discussion with experts in the field.
ContentImmunology and infection biology.
The specific topics are variable and depend each semester on the list of invited experts.
551-1518-00LMolecular Mechanisms of Health and Disease2 credits2GS. Werner, N. Aceto, M. Kopf, A. Oxenius
AbstractThe course builds on the Fundamentals in Biology courses that are taught during the first three semesters. Students will be introduced into molecular disease mechanisms with a focus on the immune system and its role in health and disease and on cancer biology.
ObjectiveTo understand the fundamental developments and functions of immune defense in multicellular organisms.

To understand the principles of physical barriers, mechanisms of local and systemic defense pathways, migration and communication of and in between immune cells, the fundamental principles of self versus non-self recognition

To understand the molecular and functional differences between a normal cell and a cancer cell

To understand the molecular mechanisms underlying cancer development and progression to metastasis, including the role of immune cells, environmental toxins and cancer-promoting viruses

To understand how vulnerabilities of cancer cells are exploited for modern cancer therapy
Lecture notesPowerpoint Slides of the Course
LiteratureCancer chapter of "Alberts, Molecular Biology of the Cell, 6th edition"
Subject-specific CompetenciesConcepts and Theoriesassessed
Techniques and Technologiesassessed