Hanspeter Nägeli: Catalogue data in Autumn Semester 2017

Name Prof. Dr. Hanspeter Nägeli
(Professor Universität Zürich (UZH))
Universität Zürich
Winterthurerstrasse 260
Inst. f. Vet.-Pharma. u. Toxikol.
8057 Zürich
Telephone044 635 87 63
Fax044 635 89 10
DepartmentHealth Sciences and Technology

376-1581-00LCancer: Fundamentals, Origin and Therapy2 credits2GH. Nägeli
AbstractGeneral aspects and etiology of cancer. Epidemiology of cancer. Impact of food, physical activity and infections. Genetic predispositions. Molecular basis of cancer development. Concept of oncogenes and tumor suppressor genes. Cancer stem cells. Interactions between chemicals and DNA. Test systems to recognize mutagenic chemicals. Conventional and new therapeutic strategies.
ObjectiveStudents are able to describe selected chemicals, biological and molecular processes that occur in cells spontaneously or after physical or chemical exposure and resulting in a tumor. They are able to list important cancer-inducing agents and explain the respective mechanism of action. They have knowledge of significant risk factors for cancer diseases. They are confronted with the basics of toxicology and they can explain the principle of the most common therapeutic strategies.
ContentThe lecture deals with problems of tumor epidemiology (causes, mortality, incidence). Cancer is delineated as a multi-step process. Classes of chemical compounds that induce cancer are discussed as well as the reactive metabolites that may be built from. Covalent binding to DNA is discussed and different types of mutations resulting therof. A selection of proto-oncogenes and tumor suppressor genes is presented. Their function will be discussed as well as the changes which are found in these genes in tumor cells, starting from single nucleotide exchanges up to large deletions.
The reason for genetic predisposition to cancer will be discussed as well as cancer relevant aspects of cell cycle regulation. The role of tumor microenvironments and phenomenons like angiogenesis and metastasis are presented as well as the mechanisms that protect the genome from mutagenic damage. Further subjects address old and new strategies of cancer treatment. Personalised cancer treatment.
Lecture notesHandouts with reproductions of all presented transparencies will be distributed.
Literature- Weinberg, Robert: The biology of Cancer. 2014. 876 S.; ISBN 978-0-8153-4220-5, Garland Science, New York, USA

additional informations are given during the lecture
Prerequisites / NoticeThe lecture requires an active participation of the students. All students will participate in individual or group work focussing on specific subject of the lecture. Students will have ample time for preparation during lecture time.
529-0745-00LGeneral and Environmental Toxicology7 credits3VM. Arand, K. Hungerbühler, H. Nägeli, B. B. Stieger, I. Werner
AbstractToxicokinetic and toxicodynamic aspects of xenobiotic interactions with cellular structures and mechanisms. Toxic responses at the level of organs (immune-, neuro-, reproductive and genotoxicity) and organisms. Introduction into developmental toxicology and ecotoxicology.
ObjectiveUnderstanding of the impact of chemicals on biological systems; evaluation of the effects from different biomedical perspectives.
ContentExplanation of important interactions between xeniobiotic chemicals and cellular structures such as membranes, enzymes, and nucleic acids. Relevance of intake, distribution, excretion, and biochemical transformation processes. Relevance of mixtures. Explanation of important modes of toxic action such as immuno toxicity, neurotoxicity, reproduction toxicity, genotoxicity based on examples of certain xenobiotics and their effects on important organs.
Lecture notesCourse material will be handed out as the lectures progress
LiteratureTextbooks of pharmacology and toxicology (cf. list in course material)
Prerequisites / NoticeEducational basis: basic chemistry, biology and biochemistry