Roger Schibli: Catalogue data in Autumn Semester 2019 |
| Name | Prof. Dr. Roger Schibli |
| Field | Radiopharmacy |
| Consultation hours | By appointment |
| Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 431 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 74 64 |
| roger.schibli@pharma.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 535-0001-00L | Introduction to Pharmaceutical Sciences I | 2 credits | 2V | J. Hall, K.‑H. Altmann, A. Burden, M. Detmar, B. A. Gander, C. Halin Winter, J.‑C. Leroux, C. Müller, D. Neri, U. Quitterer, R. Schibli, G. Schneider, H. U. Zeilhofer | |
| Abstract | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
| Learning objective | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
| Content | Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields. | ||||
| Lecture notes | Handouts for individual lectures. | ||||
| Prerequisites / Notice | Interactive teaching | ||||
| 535-0011-00L | Drug Seminar  The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences | 5 credits | 9S | U. Quitterer, K.‑H. Altmann, S. M. Ametamey, A. Burden, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, D. Neri, V. I. Otto, R. Schibli, G. Schneider, C. Steuer | |
| Abstract | The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium. | ||||
| Learning objective | The main objectives of this course are: - students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic - students gain in-depth knowledge of the topic investigated - students train their scientific writing and presentation skills - students train their ability to plan a project and work in a team | ||||
| Content | The Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences. The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester. | ||||
| Prerequisites / Notice | Only for students of MSc Pharmacy and MSc Pharmaceutical Sciences. | ||||
| 535-0210-00L | Radiopharmaceutical Chemistry | 2 credits | 2V | R. Schibli, S. M. Ametamey | |
| Abstract | Introduction of basic principles of radiation, structure and function of radiopharmaceuticals, examples of radiopharmaceuticals in nuclear medicine pactice, discussion of functional radiopharmaceuticals,molecular imaging, targeted radionuclide therapy, radiopharmaceutical synthesis. | ||||
| Learning objective | Introduction of basic priciple of radiation, structure and function of radiopharmaceuticals, examples of radiopharmaceuticals in nuclear medicine pactice, discussion of functional radiopharmaceuticals,molecular imaging, targeted radionuclide therapy, radiopharmaceutical synthesis. | ||||
| Content | Introduction radioactivity, radiopharmaceuticals, PET- and SPET- nuclides, radionuclide generators, radiopharmaceuticals for imaging the heart, infection- and lungdiagnostics, groups of brain radiopharmaceuticals, PET-kinetik modelling, molecular imaging, application in nuclear medicine, tumor-affine radiopharmaceuticals, targeted radionuclidetherapy, radioimunoconjugates, dosis calculations, nuclearmedicine prcatice, radiopharmaceutical chemistry. | ||||
| Lecture notes | https://ilias-app2.let.ethz.ch/goto.php?target=crs_115827&client_id=ilias_lda | ||||
| Literature | Reference book: Gopal B. Saha, Ph.D, Fundamentals of Nuclear Pharmacy; Verlag: Springer New York; Auflage: 6th ed. (3. November 2010) Sprache: Englisch ISBN-10: 1441958592 ISBN-13: 978-1441958594 -available at the Polybuchhandlung | ||||
| Prerequisites / Notice | Prerequisites: basic knowledge in physics and chemsitry | ||||
| 535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, J.‑C. Leroux, D. Neri, U. Quitterer, G. Schneider, H. U. Zeilhofer | |
| Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | ||||
| Learning objective | State-of-the-art information on drug discovery and development. | ||||
| Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | ||||
| 541-0002-00L | Module 2: Project Management in the Pharmaceutical Industry Does not take place this semester. Only for CAS in Pharmaceuticals. The enrolment is done by the CAS in Pharmaceuticals study administration. | 2.5 credits | 3G | R. Schibli | |
| Abstract | Pharma Project Management and Communication | ||||
| Learning objective | Project Management Basics: -About projects, project management and the project environment -How to define and plan my project, how to deal with stakeholders and how to manage project risks -Managing my project team, developing the project plan and launching the project -Managing my project team, developing the project plan and launching the project -Monitoring and reporting, project close-out and project leadership -Project evaluation and portfolio management -Budget and resource management Workshop: -Development of a generic drug product in cross-functional project teams Communication: -Intercultural communication -Negotiation skills -Presentation power | ||||
| 541-0007-00L | Module 7: Clinical Development Only for CAS in Pharmaceuticals. The enrolment is done by the CAS in Pharmaceuticals study administration. | 2.5 credits | 3G | R. Furegati Hafner, R. Schibli | |
| Abstract | Module 7 gives an overview about the several steps that have to be followed during the process of clinical development. | ||||
| Learning objective | • Preclinical bridge to clinical development • Strategy for clinical development • Regulatory aspects of clinical development • Good clinical practice (GCP) and quality assurance • First in human studies (Phase I), Proof of concept studies (Phase II), Registration studies (Phase III), Post-registration studies (Phase IV) • Monitoring • Organizational and financial aspects of clinical development • Portfolio and life cycle management • Data management and simulation of a clinical study • Personalized medicine | ||||
| 541-1000-00L | Essay Only for CAS in Pharmaceuticals. The enrolment is done by the CAS in Pharmaceuticals study administration. | 1 credit | 2D | R. Furegati Hafner, R. Schibli | |
| Abstract | The essay is an essential part of the CAS program „Pharmaceuticals – From Research to Market“ (CAS Pharm) and serves as final performance assessment. | ||||
| Learning objective | The essay documents the student’s competence development during the program as well as the transfer of acquired knowledge to professional practice/activities. | ||||
| Literature | www.postgraduate.pharma.ethz.ch documents: essay | ||||
| 542-0001-00L | Module I: Pharmacy and Legislation Only for CAS in Radiopharmazeutischer Chemie, Radiopharmacy. The enrolment is done by the CAS study administration. | 4 credits | 6G | R. Schibli, R. Furegati Hafner | |
| Abstract | Module I: Knowledge of the fundamentals of development, preparation, testing and stability of sterile radiopharmaceutical preparations. Acquirement of basic information on European legislation in Radiopharmacy including GMP and Pharmacopoeia. Understanding basics of gene engineering and pharmacokinetics | ||||
| Learning objective | • Good manufacturing practice (GMP) of classical radiopharmaceuticals • GMP: industrial point of view • Molecular and cellular aspects of radiobiology • Pharmacopoeia • Pharmacopoeia – how to use it • Design of dosage forms for pharmaceuticals • Pharmaceutical packaging • Methods of preparation of sterile products • Aseptic preparation • The role of excipients in parenteral radiopharmaceutical preparations • Sterility testing and endotoxin determination • Particulate contamination • Principles of medicinal chemistry • An overview of modern pharmaceutical analysis • Genetic engineering • Stability and shelf-life of pharmaceuticals • (in)stability of radiopharmaceuticals • Legislation in radiopharmacy • European directives – GMP • Specific radiopharmaceutical legislation • Clinical trials directive and related documents • The small scale, non-commercial preparation of radiopharmaceuticals • GMP of PET radiopharmaceuticals • Quality assurance and preparation of SOP • Water for pharmaceutical use • Practicals: visit to hospital radiopharmacy • Basic concepts of pharmacokinetics • Drug regulatory affairs • Microbiology in Pharmacy • Visit to pharmaceutical company | ||||
| 542-0003-00L | Module III: Radiopharmacology and Clinical Radiopharmacy Does not take place this semester. Only for CAS in Radiopharmazeutischer Chemie, Radiopharmacy. The enrolment is done by the CAS study administration. | 4 credits | 6G | R. Schibli | |
| Abstract | Participants will understand concepts of Pharmacology, Toxicology and Fundamentals of Nuclear Medicine | ||||
| Learning objective | • Pharmakokinetics and kinetic-modelling • Statistics and practical session • Radiotracers in biochemistry and molecular pharmacology • Selective modification of peptides and proteins to target GPCRs • Demonstration of experimental set up: Peptide and protein modification, radioactive assays in biochemistry • Visit ABX Radeberg • Nuclear medicine: basics and therapy • Immunology • Drug interventions/interactions/adverse reactions • Pharmacology basics, special aspects, clinical studies • Toxicology • Testsystems in toxicology and targeted therapeutics and cucleic acids • Nuclear medicine: clinical diagnostic applications in neurology • Nuclear medicine: visit to SPECT facility and radiopharmaceutical GMP lag (Tc, Ga, therapy) • Radiological imaging modalities- technology and applications • Nuclear medicine: clinical diagnostic applications in oncology • Radiopharmaceutical monographs in the European pharmacopoeia • Practical session, visit: cyclotron, GMP PET production and quality control, PET and PET/CT, therapy unit • Radioligand-binding-assays/autoradiography • In house tours in groups: radioligand-binding-assays, autoradiography, metabolite analytics with LC-MS, cyclotron and radiochemistry, highlights in Leipzig • Biological effects of radiation • Radiotracer transport and blood brain barrier • Radiotracers for neuroimaging | ||||