Sven Panke: Catalogue data in Spring Semester 2022 |
| Name | Prof. Dr. Sven Panke |
| Field | Bioprocess Engineering |
| Address | Bioverfahrenstechnik, Panke ETH Zürich, BSS G 43.3 Klingelbergstrasse 48 4056 Basel SWITZERLAND |
| Telephone | +41 61 387 32 09 |
| sven.panke@bsse.ethz.ch | |
| Department | Biosystems Science and Engineering |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 626-0012-00L | Bioengineering For the Focus Biomedical Engineering this course is strongly recommended to be chosen among the Electives. | 4 credits | 3G | S. Panke, J. G. Snedeker | |
| Abstract | An introduction to biology for engineers: basic biochemistry, cell metabolism (principles of energy and mass transfer in cellular systems), cell biology (structure and composition of cells, transport processes across cell membranes, growth and reproduction of cells), cellular and molecular biophysics, quantitative tools used in bio- and biomedical engineering | ||||
| Learning objective | Students that already posses an engineering background will be exposed to a broad introduction of fundamental concepts in the fields of biology and chemistry. Focus will be given to aspects relevant to research and development projects in the fields of biotechnology, bioprocess engineering, or biomedical devices. The course will highlight technically exploitable elements in biology and chemistry, to provide the basic understanding and a necessary vocabulary for interdisciplinary communication with biologists / biotechnologists. | ||||
| Content | Basic biochemistry, cell metabolism (principles of energy and mass transfer in the cell, biocatalysis and enzymes, cellular respiration, protein synthesis, regulation), cellular biology (structure and composition of cells, transport processes across cell membranes, growth and reproduction of cells) , introduction to biotechnology tools and applications of molecular and cellular engineering. | ||||
| Lecture notes | Lecture slides and supporting material made available for download on Moodle. | ||||
| Literature | NA Campbell, JB Reece : Biology, Oxford University Press; B. Alberts et al : Molecular Biology of the Cell , Garland Science; J. Koolman , Roehm KH : Color Atlas of Biochemistry, Thieme-Verlag.; CR Jacobs, H Huang, RY Kwon: Introduction to Cell Mechanics and Mechanobiology, Garland Science; | ||||
| 636-0111-00L | Synthetic Biology I | 4 credits | 3G | S. Panke, J. Stelling | |
| Abstract | Theoretical & practical introduction into the design of dynamic biological systems at different levels of abstraction, ranging from biological fundamentals of systems design (introduction to bacterial gene regulation, elements of transcriptional & translational control, advanced genetic engineering) to engineering design principles (standards, abstractions) mathematical modelling & systems desig | ||||
| Learning objective | After the course, students will be able to theoretically master the biological and engineering fundamentals required for biological design to be able to participate in the international iGEM competition. | ||||
| Content | The overall goal of the course is to familiarize the students with the potential, the requirements and the problems of designing dynamic biological elements that are of central importance for manipulating biological systems, primarily (but not exclusively) prokaryotic systems. Next, the students will be taken through a number of successful examples of biological design, such as toggle switches, pulse generators, and oscillating systems, and apply the biological and engineering fundamentals to these examples, so that they get hands-on experience on how to integrate the various disciplines on their way to designing biological systems. | ||||
| Lecture notes | Handouts during classes. | ||||
| Literature | Mark Ptashne, A Genetic Switch (3rd ed), Cold Spring Haror Laboratory Press Uri Alon, An Introduction to Systems Biology, Chapman & Hall | ||||
| Prerequisites / Notice | 1) Though we do not place a formal requirement for previous participation in particular courses, we expect all participants to be familiar with a certain level of biology and of mathematics. Specifically, there will be material for self study available on https://bsse.ethz.ch/bpl/education/lectures/synthetic-biology-i/download.html as of mid January, and everybody is expected to be fully familiar with this material BEFORE THE CLASS BEGINS to be able to follow the different lectures. Please contact sven.panke@bsse.ethz.ch for access to material 2) The course is also thought as a preparation for the participation in the international iGEM synthetic biology summer competition (www.syntheticbiology.ethz.ch, http://www.igem.org). This competition is also the contents of the course Synthetic Biology II. https://bsse.ethz.ch/bpl/education/lectures/synthetic-biology-i/download.html | ||||
| 636-0115-00L | Biochemical Engineering | 4 credits | 3G | S. Panke, W. Minas | |
| Abstract | The course covers the fundamentals of implementing biotechnological reactions and cultivations into reactors and major methods of product purification. | ||||
| Learning objective | The objective is to instruct students in the key concepts that are required for efficient application of biotechnological systems (enzymes and cells) for the production of chemicals and proteins. | ||||
| Content | Enzyme kinetics – mass transfer in heterogeneous systems – enzyme reactors – residence time distributions - upstream processing of fermentation processes – ideal reactors – macrokinetics - gas transfer – membrane processes – chromatography | ||||
| Lecture notes | Handouts and text book references will be provided over the course. | ||||
| Literature | Eg Pauline Doran, Bioprocess Engineering, Clark & Blanch, Biochemical Engineering, Harrison and Todd, Bioseparation Science and Engineering | ||||
| 636-1002-AAL | Bio II: Biochemistry Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 5 credits | 7R | S. Panke | |
| Abstract | |||||
| Learning objective | |||||
| Literature | Stryer “Biochemistry”, chapters: 1-18, 24, 27-32 | ||||
| 636-1009-AAL | Bio Lab IV: Molecular Biology II Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 1 credit | 3R | S. Panke | |
| Abstract | |||||
| Learning objective | |||||
| Content | Gene expression in prokaryotes: Construction of reporter constructs, induction and readout under different conditions, influence of degradation tags, genome editing in bacteria | ||||
| 636-1010-AAL | Bio Lab V: Molecular Biology III Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 1 credit | 3R | S. Panke | |
| Abstract | |||||
| Learning objective | |||||
| Content | “-omics” analyses in eukaryotic cells (sample preparation for and analysis of omics data) | ||||