Manfred Kopf: Catalogue data in Autumn Semester 2023 |
| Name | Prof. Dr. Manfred Kopf |
| Field | Molecular Biomedicine |
| Address | Inst. f. Molecular Health Sciences ETH Zürich, HPL G 12 Otto-Stern-Weg 7 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 64 70 |
| Fax | +41 44 633 13 50 |
| manfred.kopf@biol.ethz.ch | |
| URL | https://mhs.biol.ethz.ch/research/kopf.html |
| Department | Biology |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 551-0223-00L | Immunology III | 4 credits | 2V | M. Kopf, S. B. Freigang, S. R. Leibundgut, F. Mair, A. Oxenius, C. Schneider, E. Slack, R. Spörri, further lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This course provides a detailed understanding of - development of T and B cells - the dynamics of a immune response during acute and chronic infection - mechanisms of immunopathology - modern vaccination strategies Key experimental results will be shown to help understanding how immunological text book knowledge has evolved. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Obtain a detailed understanding of - the development, activation, and differentiation of different types of T cells and their effectormechanisms during immune responses, - Recognition of pathogenic microorganisms by the host cells and molecular events thereafter, - events and signals for maturation of naive B cells to antibody producing plasma cells and memory B cells. - Optimization of B cell responses by intelligent design of new vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg) o NK T cells and responses to lipid antigens o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17 o Overview of cytokines and their effector function o Co-stimulation (signals 1-3) o Dendritic cells o Evolution of the "Danger" concept o Cells expressing Pattern Recognition Receptors and their downstream signals o T cell function and dysfunction in acute and chronic viral infections | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Documents of the lectures are available for download at: https://moodle-app2.let.ethz.ch/course/view.php?id=2581¬ifyeditingon=1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Immunology I and II recommended but not compulsory | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-0317-00L | Immunology I | 3 credits | 2V | M. Kopf, A. Oxenius | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Introduction into structural and functional aspects of the immune system. Basic knowledge of the mechanisms and the regulation of an immune response. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Introduction into structural and functional aspects of the immune system. Basic knowledge of the mechanisms and the regulation of an immune response. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | - Introduction and historical background - Innate and adaptive immunity, Cells and organs of the immune system - B cells and antibodies - Generation of diversity - Antigen presentation and Major Histoincompatibility (MHC) antigens - Thymus and T cell selection - Autoimmunity - Cytotoxic T cells and NK cells - Th1 and Th2 cells, regulatory T cells - Allergies - Hypersensitivities - Vaccines, immune-therapeutic interventions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Electronic access to the documentation will be provided. The link can be found at "Lernmaterialien" | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | - Kuby, Immunology, 9th edition, Freemen + Co., New York, 2020 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | For D-BIOL students Immunology I (WS) and Immunology II (SS) will be examined as one learning entity in a "Sessionsprüfung". All other students write separate exams for Immunology I and Immunology II. All exams (combined exam Immunology I and II, individual exams) are offered in each exam session. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Competencies |
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| 551-0509-00L | Current Immunological Research in Zurich | 0 credits | 1K | R. Spörri, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Presentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | none | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-1117-00L | Cutting Edge Topics: Immunology and Infection Biology Information for UZH students: Enrolment to this course unit only possible at ETH. No enrolment to module BIO636 at UZH. Please mind the ETH enrolment deadlines for UZH students: Link | 2 credits | 1S | A. Oxenius, B. Becher, C. Halin Winter, M. Kopf, S. R. Leibundgut, C. Münz, L. Tortola, M. van den Broek | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion. The aim of this course is to confront students with current research topics and with scientific presentation. The course offers the opportunity to gain in depth knowledge about diverse topics which are often only briefly touched in the concept courses and to engage in discussion with experts in the field. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Immunology and infection biology. The specific topics are variable and depend each semester on the list of invited experts. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Current research data (often not yet published) are presented in this seminar series. There is no script and we are not allowed to record or distribute the contents of the seminars. Thus, the ability of students to extract the most relevant points of each seminar is promoted, which is an important skill for the future attendance of scientific meetings. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Often parts of the presented seminars have already been published by the respective speakers and the respective primary research can be retrieved from scientific journals. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 551-1709-00L | Genomic and Genetic Methods in Cell and Developmental Biology  Number of participants limited to 8. The enrolment is done by the D-BIOL study administration. | 6 credits | 7P | A. Wutz, M. Kopf, T. Schroeder | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This course aims to provide students with a comprehensive overview of mammalian developmental biology and stem cell systems both on the theoretical as well as the experimental level. Centering the course on genetic and genomic methods engages the students in contemporary research and prepares for future studies in the course of semester and master projects. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | - Understanding mammalian development - Introduction to stem cells systems - Working with cultured cells - Translational aspects of mammalian cell biology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course will consist of a series of lectures, assay assignments, project development and discussion workshops, and 2 and a half week of lab work with different mammalian cell systems embedded in real life research projects. At the end of the course students will take an exam consisting of questions on the topic of the lectures and workshops. It is expected that students will be able to apply the knowledge to concrete problems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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