Manfred Kopf: Catalogue data in Autumn Semester 2016

Name	Prof. Dr. Manfred Kopf
Field	Molecular Biomedicine
Address	Inst. f. Molecular Health Sciences ETH Zürich, HPL G 12 Otto-Stern-Weg 7 8093 Zürich SWITZERLAND
Telephone	+41 44 633 64 70
E-mail	manfred.kopf@biol.ethz.ch
URL	https://mhs.biol.ethz.ch/research/kopf.html
Department	Biology
Relationship	Full Professor

Number	Title	ECTS	Hours	Lecturers
551-0223-00L	Immunology III	4 credits	2V	M. Kopf, M. Bachmann, J. Kisielow, A. Lanzavecchia, S. R. Leibundgut, A. Oxenius, R. Spörri
Abstract	This course provides a detailed understanding of - development of T and B cells - the dynamics of a immune response during acute and chronic infection - mechanisms of immunopathology - modern vaccination strategies Key experimental results will be shown to help understanding how immunological text book knowledge has evolved.
Learning objective	Obtain a detailed understanding of - the development, activation, and differentiation of different types of T cells and their effectormechanisms during immune responses, - Recognition of pathogenic microorganisms by the host cells and molecular events thereafter, - events and signals for maturation of naive B cells to antibody producing plasma cells and memory B cells. - Optimization of B cell responses by intelligent design of new vaccines
Content	o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg) o NK T cells and responses to lipid antigens o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17 o Overview of cytokines and their effector function o Co-stimulation (signals 1-3) o Dendritic cells o Evolution of the "Danger" concept o Cells expressing Pattern Recognition Receptors and their downstream signals o T cell function and dysfunction in acute and chronic viral infections
Literature	Documents of the lectures are available for download at: https://moodle-app2.let.ethz.ch/course/view.php?id=2581&notifyeditingon=1
Prerequisites / Notice	Immunology I and II recommended but not compulsory
551-0317-00L	Immunology I	3 credits	2V	A. Oxenius, M. Kopf
Abstract	Introduction into structural and functional aspects of the immune system. Basic knowledge of the mechanisms and the regulation of an immune response.
Learning objective	Introduction into structural and functional aspects of the immune system. Basic knowledge of the mechanisms and the regulation of an immune response.
Content	- Introduction and historical background - Innate and adaptive immunity, Cells and organs of the immune system - B cells and antibodies - Generation of diversity - Antigen presentation and Major Histoincompatibility (MHC) antigens - Thymus and T cell selection - Autoimmunity - Cytotoxic T cells and NK cells - Th1 and Th2 cells, regulatory T cells - Allergies - Hypersensitivities - Vaccines, immune-therapeutic interventions
Lecture notes	Electronic access to the documentation will be provided. The link can be found at "Lernmaterialien"
Literature	- Kuby, Immunology, 7th edition, Freemen + Co., New York, 2009
Prerequisites / Notice	Immunology I (WS) and Immunology II (SS) will be examined as one learning entity in a "Sessionsprüfung".
551-0509-00L	Current Immunological Research in Zürich	0 credits	1K	R. Spörri, M. Detmar, C. Halin Winter, W.‑D. Hardt, M. Kopf, A. Lanzavecchia, S. R. Leibundgut, A. Oxenius, University lecturers
Abstract	This monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion.
Learning objective	The aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups.
Content	Presentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich.
Lecture notes	none
551-1117-00L	Cutting Edge Topics: Immunology and Infection Biology	2 credits	1S	A. Oxenius, B. Becher, C. Halin Winter, M. Kopf, S. R. Leibundgut, C. Münz, A. Trkola, M. van den Broek
Abstract	Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion.
Learning objective	Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion. The aim of this course is to confront students with current research topics and with scientific presentation. The course offers the opportunity to gain in depth knowledge about diverse topics which are often only briefly touched in the concept courses and to engage in discussion with experts in the field.
Content	Immunology and infection biology. The specific topics are variable and depend each semester on the list of invited experts.
551-1171-00L	Immunology: from Milestones to Current Topics	4 credits	2S	B. Ludewig, J. Kisielow, M. Kopf, A. Oxenius, University lecturers
Abstract	Milestones in Immunology: on old concepts and modern experiments
Learning objective	The course will cover six grand topics in immunology (B cells, innate immunity, antigen presentation, tumor immunity, thymus and T cells, cytotoxic T cells and NK cells) and for each grand topic four hours will be allocated. During the first double hour, historical milestone papers will be presented by the supervisor providing an overview on the development of the conceptional framework and critical technological advances. The students will also prepare themselves for this double lecture by reading the historical milestone papers and contributing to the discussion. In the following lecture up to four students will present each a recent high impact research paper which emerged from the landmark achievements of the previously discussed milestone concepts.
Content	Milestones and current topics of innate immunity, antigen presentatino, B cells, thymus and T cells, cytotoxic T cells and NK cells, and tumor immunology.
Lecture notes	Original and review articles will be distributed by the lecturer.
Literature	Literaturunterlagen werden vor Beginn des Kurses auf folgender website zugänglich sein: Moodle Course https://moodle-app2.let.ethz.ch/course/view.php?id=1002
551-1709-00L	Genomic and Genetic Methods in Cell and Developmental Biology Number of participants limited to 11.	6 credits	7G	A. Wutz, C. Beyer, M. Kopf, T. Schroeder, G. Schwank
Abstract	This course aims to provide students with a comprehensive overview of mammalian developmental biology and stem cell systems both on the theoretical as well as the experimental level. Centering the course on genetic and genomic methods engages the students in contemporary research and prepares for future studies in the course of semester and master projects.
Learning objective	- Understanding mammalian development - Introduction to stem cells systems - Working with cultured cells - Translational aspects of mammalian cell biology
Content	The course will consist of a series of lectures, assay assignments, project development and discussion workshops, and 2 and a half week of lab work with different mammalian cell systems embedded in real life research projects. At the end of the course students will take an exam consisting of questions on the topic of the lectures and workshops. It is expected that students will be able to apply the knowledge to concrete problems.