Ruth Kroschewski: Catalogue data in Spring Semester 2022

Name	Dr. Ruth Kroschewski
Address	Institut für Biochemie ETH Zürich, HPM D 11.3 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND
Telephone	+41 44 632 63 46
Fax	+41 44 632 15 91
E-mail	ruth.kroschewski@bc.biol.ethz.ch
Department	Biology
Relationship	Lecturer

Number	Title	ECTS	Hours	Lecturers
551-0128-00L	Fundamentals of Biology I Registrations via myStudies until 28.1.2022 at the latest. Subsequent registrations will not be considered.	8 credits	8P	M. Gstaiger, A. Cléry, E. Dultz, C. H. Giese, R. Kroschewski, M. Künzler
Abstract	This 1st year Laboratory course introduces the students to the basic experimental techniques used in the classical and modern molecular biosciences. In the first year (Praktikum GL BioI) the students will be introduced into the basic concepts and methods of Microbiology, Biochemistry and Molecular Biology in 12 consecutive course days.
Learning objective	Introduction to the biology of unicellular organisms and practical experience with biochemical and molecular biology techniques. General Praktikum-information and course material can be obtained from Moodle The general Praktikum information (Assignment list, Instructions and Schedule & Performance Sheet) will also be sent to the students directly (E-mail).
Content	This 1st year Laboratory course introduces the students to the entire range of classical and modern molecular biosciences. Students will participate in 12 consecutive course days. The practical will operate in two shifts on Thursday and Friday. morning shift 8:00-13:00 afternoon shift 13:30-18:30 Program Day 1: Handling and detection of microorganisms Day 2: Morphological, biochemical and genetic differentiation of microorganisms Day 3: Biotic interactions and genetics of bacteria Day 4: Metabolism and physiology of bacteria Day 5: DNA extraction, tranformation (E.coli, yeast) Day 6: RNA extraction, Life cycle of eukaryotic cells Day 7: Purification of TAQ polymerase from E coli by ionexchange chromatography Day 8: Characterizing fractions of the purification of TAQ polymerase (SDS-PAGE, WB) Day 9: mRNA splicing in yeast by RT-PCR and purified TAQ polymerase Day 10: Affinity chromatography, protein crystallization and structure Day 11: Protein folding, protein stability and Enzyme kinetics Day 12: Protein folding, protein stability and Enzyme kinetics
Lecture notes	Laboratory manuals can be downloaded from Moodle
Prerequisites / Notice	PLEASE NOTE THE FOLLOWING RULES Your attendance is obligatory and you have to attend all 12 Praktikum days of GL BioI. Absences are only acceptable if you are able to provide a Doctor’s certificate. The original Dr's certificate has to be given to Dr. M. Gstaiger (HPM F43) within five days of the absence of the Praktikum day. If there will be any exceptional or important situations then you should directly contact the Director of Studies of D-Biol, who will decide if you are allowed to miss a Praktikum day or not. HIGHLY IMPORTANT!! 1. Due to the increased number of students, the official Praktikum registration has to be done, using myStudies, preferably at the end of HS21 but not later than January 28, 2022. 2. Later registration is NOT possible and can NOT be accepted! 3. The course registration for FS2022 is usually possible at the end of fall semester 2021 and you will obtain an E-mail from the Rectorate when the course registration using myStudies is possible. The 12 course days of the Praktikum Grundlagen Biologie-I will take place Thursday or Friday during the spring semester 2022. Therefore, you have to make sure already now that you will not have any other activities / commitments during these days. The exact course schedule will be communicated before the beginning of the spring semester. PRAKTIKUM DAYS FS22 (Thursdays): 24.02.; 03.03.; 10.03.; 17.03.; 24.03.; 31.03.; 07.04.; 28.04.; 5.05.; 12.05.; 19.05.; 02.06. PRAKTIKUM DAYS FS22 (Fridays): 25.02.; 04.03.; 11.03.; 18.03.; 25.03.; 1.04.; 8.04.; 29.04.; 06.05.; 13.05.; 20.05.; 03.06. No Praktikum during the Easter vacation: 11.04-22.04.
551-0320-00L	Cellular Biochemistry (Part II)	3 credits	2V	Y. Barral, R. Kroschewski, A. E. Smith
Abstract	This course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
Learning objective	The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
Content	Spatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
Literature	Recommended supplementary literature may be provided during the course.
Prerequisites / Notice	To attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English. In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-1300-00L	Cause and Consequences of Unstable Genomes Number of participants limited to 12. The enrolment is done by the D-BIOL study administration.	6 credits	7P	M. Jagannathan, Y. Barral, R. Kroschewski, G. Neurohr
Abstract	The course will introduce students to key concepts and laboratory research within the broad field of "Genome stability".
Learning objective	Students will learn to design, apply and evaluate current research strategies in a wide range of modern research areas encompassing the broad field of "Genome stability".
Content	The course will consist of lectures, practical laboratory work in small groups, informal progress report sessions, and the presentation of laboratory work. Lectures will expose students to key concepts and techniques in the field. Students will team into small groups and work in one laboratory for the duration of the course. Students will meet regularly for informal "progress report" discussions of their projects. Student performance will be assessed based on the quality of their practical work, a written exam on frontal lecture material, and a presentation of their practical work.
Literature	Documentation and recommended literature in the form of review articles and selected primary literature will be provided during the course.
Prerequisites / Notice	This course will be taught in English.