Yves Barral: Catalogue data in Spring Semester 2022

Name	Prof. Dr. Yves Barral
Field	Biochemie
Address	Institut für Biochemie ETH Zürich, HPM D 8.3 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND
Telephone	+41 44 632 06 78
Fax	+41 44 632 15 91
E-mail	yves.barral@bc.biol.ethz.ch
Department	Biology
Relationship	Full Professor

Number	Title	ECTS	Hours	Lecturers
551-0126-00L	Fundamentals of Biology II: Cells	6 credits	5G	K. Weis, F. Allain, Y. Barral, W.‑D. Hardt, U. Kutay, M. Peter, I. Zemp
Abstract	The lecture provides an introduction to the function and regulations of cells.
Learning objective	Introduction to the function and regulation of cells
Content	The lecture introduces a basic understanding of the structure, organization, function and regulation of the cell. The lecture is divided into two main sections: Part 1: Cell Biology of Prokaryotes, evolution, populations This section covers the general principles of the structure and regulation of prokaryotic cells, and explains the genetics and the evolution of bacteria. Part II: Unifying concepts in Eukarya This part of the lecture gives a broad introduction into the general structure of eukaryotic cells and illustrates key concepts such as intracellular architecture, transport mechanisms and the regulation of gene expression in eukaryotes.
Lecture notes	The newly conceived lecture is supported by scripts.
Literature	The lecture is supported by scripts. Furthermore, the textbook "Molecular Biology of the Cell", Alberts et al. 6th edition, Taylor and Francis, and "Brock Biology of Microorganisms", Madigan et al. 15th edition, Pearson can be used as support for the lecture.
551-0320-00L	Cellular Biochemistry (Part II)	3 credits	2V	Y. Barral, R. Kroschewski, A. E. Smith
Abstract	This course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
Learning objective	The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
Content	Spatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
Literature	Recommended supplementary literature may be provided during the course.
Prerequisites / Notice	To attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English. In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-0339-00L	Molecular Mechanisms of Cell Dynamics Number of participants limited to 18. The enrolment is done by the D-BIOL study administration.	6 credits	7P	E. Dultz, Y. Barral, U. Kutay, M. Peter, K. Weis
Abstract	Application of current experimental strategies to study the dynamics of complex and highly regulated cellular processes.
Learning objective	In this course, students will - learn what principles govern cellular dynamics and how these are regulated. - learn to evaluate and to apply current strategies to study the dynamics of complex and highly regulated cellular processes
Content	During this Block-Course, the students will learn to (1) describe the important mechanisms and regulators of dynamic processes in cells, (2) perform experimental techniques to quantify dynamic cellular processes, (3) evaluate and compare experimental strategies and model systems, (4) formulate and present scientific concepts in an oral presentation. Topics discussed will include - mobility in the cell (passive and active) - compartmentalization (by membranes and via phase separation) - examples of cell biological processes dependent on mobility and compartmentalization. Students will work in small groups in individual labs on one research project (8 full days of practical work; every group of students will stay in the same lab during the entire course). The projects are close to the actual research carried out in the participating research groups, but with a clear connection to the subject of the course.
Literature	Documentation and recommended literature (review articles and selected primary literature) will be provided during the course.
Prerequisites / Notice	This course will be taught in english.
551-0974-00L	Specialized Biology Course with an Educational Focus: Biological Concepts	6 credits	2G + 13A	Y. Barral, K. Köhler, H. Stocker
Abstract	Specialist aspects of biology with a focus on biological concepts and misconceptions are covered from the angle of imparting these to pupils, their historical development, and their significance for the subject, the individual and society.
Learning objective	After successful completion of the module, students should be able - to explain biological concepts and principles, as well as the way they fit together - to recognise and to correct existing misconceptions - to analyse controversial topics and to give factual explanations for these - to conduct more in-depth work on a research topic and to compile a tuition unit based on this topic - to prepare tuition units involving complex learning matter at a high specialist level which are suitably tailored to the recipients, and to teach these in a manner conducive to learning.
Content	Selected biological topics are dealt with under consideration of the special needs of persons involved in teaching. The module comprises lectures, a book club, and a seminar thesis.
Lecture notes	Teaching materials are available online on Moodle.
Literature	Literature and references are posted online on Moodle.
Prerequisites / Notice	The Specialized Biology Course with an Educational Focus consists of two modules (6 CP each). In the fall semester, the focus is on evolution. The module of the spring semester deals with biological concepts. Students attending both modules can start with either module. Performance is assessed during the course of the entire module. Active participation in the course is required. The electronic thesis and an oral presentation have to be completed. The Specialized Biology Course with an Educational Focus (6+6 CP) can be acknowledged, in agreement with the advisor of the respective elective major, as one of the two obligatory research projects (each 15 CP). In such a case, additional 3 CP must be obtained in another course. In case of overbooking of the course, students enrolled in the Teaching Diploma in Biology will have priority.
551-1300-00L	Cause and Consequences of Unstable Genomes Number of participants limited to 12. The enrolment is done by the D-BIOL study administration.	6 credits	7P	M. Jagannathan, Y. Barral, R. Kroschewski, G. Neurohr
Abstract	The course will introduce students to key concepts and laboratory research within the broad field of "Genome stability".
Learning objective	Students will learn to design, apply and evaluate current research strategies in a wide range of modern research areas encompassing the broad field of "Genome stability".
Content	The course will consist of lectures, practical laboratory work in small groups, informal progress report sessions, and the presentation of laboratory work. Lectures will expose students to key concepts and techniques in the field. Students will team into small groups and work in one laboratory for the duration of the course. Students will meet regularly for informal "progress report" discussions of their projects. Student performance will be assessed based on the quality of their practical work, a written exam on frontal lecture material, and a presentation of their practical work.
Literature	Documentation and recommended literature in the form of review articles and selected primary literature will be provided during the course.
Prerequisites / Notice	This course will be taught in English.