Rik Eggen: Katalogdaten im Frühjahrssemester 2018

NameHerr Prof. Dr. Rik Eggen
Überlandstrasse 133
8600 Dübendorf
Telefon058 765 53 20
Fax058 765 58 02

701-1312-00LAdvanced Ecotoxicology3 KP2VR. Eggen, E. Janssen, K. Schirmer, M. Suter
KurzbeschreibungThis course will take up the principles of environmental chemistry and ecotoxicology from the bachelor courses and deepen the understanding on selected topics. Linkages will be made between i) bioavailability and effects, ii) structures of compounds and modes of toxic action, iii) effects over various biological levels, moderated by environmental factors, iv) chemical and biological assessments
Lernziel- Understanding the key processes involved in fate, behavior and the bioaccumulation of (mainly) organic contaminants
- Overview on and understanding of mechanisms of toxicity
- linking structures and characteristics of compounds with effects
- processes in hazard assessment and risk assessment
- get insight in integrative approaches in ecotoxicology
InhaltUnits 1-3: Fate of contaminants, dynamic interactions with the (a)biotic environment, toxikokinetics
- physico-chemical properties
- partitioning processes in environmental compartments
- partitioning to biota
- bioavailability and bioaccumulation concepts
- partitioning in biota

Units 4-6: Toxicodynamics (effect of contaminants on biota)
- internal concentrations; dose-response concept
- molecular mechanisms of toxic actions - classification
- Exercise: databases and estimation of toxicity

Unit 7-10: Toxic effects: from molecular to ecosystems
- complex mechanisms and feedback loops
- mixtures and multiple stressors
- stress- and adaptive responses
- dynamic exposures
- confounding factors, food web interactions
- Exercise: linking compounds with modes of toxic action

Unit 11: metal ecotoxicology

Unit 12-14: integrative approaches and case studies
- bioassays, -omics, systems ecotoxicology, phenotypic anchoring
- in vivo versus in vitro biotesting
- linking chemical with biological analytics
- bioassay-directed fractionation and identification
- (inter) national case studies and linkage of learned with approaches in practice
SkriptParts of scripts will be distributed, otherwise copies of overheads and selected publications
LiteraturR.P. Schwarzenbach, P.M. Gschwend, D.M. Imboden, Environmental Organic Chemistry, third edition, Wiley, 2005

C.J. van Leeuwen, J.L.M. Hermens (Editoren), Risk Assessment of Chemicals: An Introduction, Kluwer, 1995

Principles of ecotoxicology, CH Walker, RM Sibly, SP Hopkin, DB Peakall, fourth edition, CRC Press, 2012
Voraussetzungen / BesonderesRequired:

1. Basics in environmental chemistry

2. Basics in environmental toxicology
752-1300-00LIntroduction to Toxicology3 KP2VR. Eggen, S. J. Sturla
KurzbeschreibungIntroduction to how chemical properties and biological interactions govern the disposition and influences of toxicants.
LernzielThe objectives are for the student to establish a framework for examining adverse effects resulting from exposures to toxicants by understanding key mechanisms that give rise to toxic responses and disease processes.
InhaltThis course will introduce mechanisms governing the chemical disposition and biological influences of toxicants. The course is geared toward advanced bachelors students in food science, environmental science, and related disciplines, such as chemistry, biology and pharmaceutical sciences. Examples of topics include: dose-response relationships and risk assessment, absorption, transport, and biotransformation of xenobiotic chemicals; Carcinogenesis; DNA damage, repair, and mutation; Immunotoxicity; Neurotoxicity; and modern toxicity testing strategies. These fundamental concepts in Mechanistic Toxicology will be integrated with examples of toxicants relevant to food, drugs and the environment.
LiteraturCasarett & Doull's Toxicology, The Basic Science of Poisons. Seventh Edition. Editor: Curtis D. Klaassen, 2008, McGraw-Hill. (available on-line)
Voraussetzungen / BesonderesBasic knowledge of organic chemistry and biochemistry is required.