|Name||Prof. Dr. Sabine Werner|
Inst. f. Molecular Health Sciences
ETH Zürich, HPL F 12
|Telephone||+41 44 633 39 41|
|Fax||+41 44 633 11 74|
|551-0103-AAL||Fundamentals of Biology II: Cell Biology|
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.
Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
|5 credits||11R||U. Kutay, Y. Barral, E. Hafen, G. Schertler, U. Suter, S. Werner|
|Abstract||The goal of this course is to provide students with a wide general understanding in cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.|
|Objective||The goal of this course is to provide students with a wide general understanding cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.|
|Content||The focus is animal cells and the development of multicellular organisms with a clear emphasis on the molecular basis of cellular structures and phenomena. The topics include biological membranes, the cytoskeleton, protein sorting, energy metabolism, cell cycle and division, viruses, extracellular matrix, cell signaling, embryonic development and cancer research.|
|Literature||Alberts et al. 'Molecular Biology of the Cell' 6th edition, 2014, ISBN 9780815344322 (hard cover) and ISBN 9780815345244 (paperback).|
Analyzing cells & molecules / Gebhard Schertler/8/ 439-463;
Membrane structure / Gebhard Schertler/ 10/ 565-595;
Compartments and Sorting/ Ulrike Kutay/12+14+6/641-694/755-758/782-783/315-320/325 -333/Table 6-2/Figure6-20, 6-21, 6-32, 6-34;
Intracellular Membrane Traffic/ Ulrike Kutay/13/695-752;
The Cytoskeleton/ Ulrike Kutay/ 16/889 - 948 (only the essentials);
Membrane Transport of Small Molecules and the Electrical Properties of Membranes /Sabine Werner/11/597 - 633;
Mechanisms of Cell Communication / Sabine Werner/15/813-876;
Cancer/ Sabine Werner/20/1091-1141;
Cell Junctions and Extracellular Matrix/Ueli Suter / 1035-1081;
Stem Cells and Tissue Renewal/Ueli Suter /1217-1262;
Development of Multicellular organisms/ Ernst Hafen/ 21/ 1145-1179 /1184-1198/1198-1213;
Cell Migration/Joao Matos/951-960;
Cell Death/Joao Matos/1021-1032;
Cell Cycle/chromosome segregation/Cell division/Meiosis/Joao Matos/ 963-1018.
|Prerequisites / Notice||none|
|551-0104-00L||Fundamentals of Biology II |
Registrations via myStudies until 29.1.2021 at the latest. Subsequent registrations will not be considered.
General safety regulations:
-Whenever possible the distance rules have to be respected.
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged.
-Any additional rules for individual courses have to be respected.
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible.
|8 credits||8P||M. Gstaiger, E. Dultz, W. Kovacs, H. Stocker, S. Sunagawa, U. Suter, S. Werner|
|Abstract||This introductory Laboratory course introduces the student to the entire range of classical and modern molecular biosciences. In the second year (Praktikum GL Bio II) the students will perform three praktikum days in:|
- Plant Physiology
- Genetics and
- Cell Biology II.
(total of 12 experiments)
Each experiment takes one full day.
|Objective||Introduction to theoretical and experimental biology|
Moodle www-link for general Praktikum-information and course material: Moodle
The general Praktikum information (Assignment list, Instructions and Schedule & Performance Sheet) will also be sent to the students directly (E-mail).
|Content||The class is divided into four blocks: Cell Biology II, Genetics, Bioinformatics and Plant Physiology. One block lasts three weeks.|
CELL BIOLOGY II:
- Cells: Cell types & staining methods, cell fusion & cell motility,
- Tissue and development: histology of mice embryos & embryogenesis
- Repair mechanisms: DNA repair & wound healing,
- Yeast genetics
- Drosophila genetics
- Human genetics
- the command line interface (UNIX/LINUX)
- reinforce programming skills in R
- programmatic, analytical and statistical principles
- Plants and light
- Phytohormones and other growth factors
- Molecular biology of systemic gene silencing
- Literature and presentations
The students will also prepare short presentations (approx. 10 min) of the various topics within this course.
|Lecture notes||Laboratory manuals|
CELL BIOLOGY II
- The protocols can be downloaded from: Moodle
- The protocols can be found from: Moodle
- The protocols can be found from: Moodle
- The protocols can be found from: Moodle
|Prerequisites / Notice||THE PRAKTIKUM RULES:|
Your attendance is obligatory and you have to attend all 12 Praktikum days. Absences are only acceptable if you are able to provide a Doctor’s certificate. The original Dr's certificate has to be given to Dr. M. Gstaiger (HPM F43) within five days of the absence of the Praktikum day.
If there will be any exceptional or important situations then you should directly contact the Director of Studies of D-Biol, who will decide if you are allowed to miss a Praktikum day or not.
1. Due to the increased number of students, the official Praktikum registration has to be done, using myStudies, preferably at the end of HS20 but not later than Wednesday January 29, 2021.
2. Later registration is NOT possible and can NOT be accepted!
3. The course registration for FS21 is usually possible at the end of HS20 and you will obtain an E-mail from the Rectorate when the course registration using myStudies is possible.
Students can register for a practice group via myStudies. As soon as the course unit is registered in myStudies, a text box appears indicating that a group can be selected. Accordingly, students can select a group in the next step. If more than 180 students register, the surplus students will be placed on a waiting list and then allocated by the course responsible.
The Praktikum GL BioII FS21 will take place during the following days and therefore, you have to make sure already now that you do not have any other activities & commitments during these days:
PRAKTIKUM DAYS DURING FS21 (Fridays):
26.02.; 05.03.; 12.03.; 19.03.; 26.03.; 16.04.; 23.04.; 30.04.; 07.05.; 21.05.; 28.05.; 04.06.
No Praktikum during the Easter break: 02.04-09.04.
|551-0326-00L||Cell Biology||6 credits||4V||S. Werner, H. Gehart, W. Kovacs, M. Schäfer, U. Suter, A. Wutz, further lecturers|
|Abstract||This Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.|
|Objective||-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.|
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.