Roland Riek: Katalogdaten im Herbstsemester 2022

NameHerr Prof. Dr. Roland Riek
LehrgebietPhysikalische Chemie
Inst. Mol. Phys. Wiss.
ETH Zürich, HCI F 225
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
Telefon+41 44 632 61 39
DepartementChemie und Angewandte Biowissenschaften
BeziehungOrdentlicher Professor

529-0019-00LCharacterization of the Aggregation Landscape of Peptide Amyloids and their Chemical Templating
The enrolment is done by the D-BIOL study administration.

Number of participants limited to 6.
6 KP7PR. Riek, J. Greenwald
KurzbeschreibungShort peptide amyloids are models for their more complex protein counterparts in the study of disease-related and functional aggregation as well as being interesting in their own right as molecules that may have played a role in the origin of life. This block course will allow the students to study novel peptides in order to characterize their aggregation landscape and also to assess the ability o
LernzielDuring the block course, each student will learn how to handle aggregation-prone peptides, characterize their aggregation state and structure as well as assay their ability to template their own chemical synthesis.
InhaltThe course is divided between lectures practical work in the lab. The lectures will introduce the general topic of amyloids and in particular their potential role in the origin of molecular complexity, as well as cover the theory and the practice behind the tools that are used to characterize peptide amyloids. The practical work in the lab will allow the students to gain hands-on experience working on a novel peptide that has yet to be characterized. Since the course consists of genuine research we also hope that new discoveries will be made that will provide insights into the role that amyloids may have played in the origin of life.
SkriptA script will be distributed to the participants on the first day of the course.
LiteraturGreenwald, J., Kwiatkowski, W., Riek, R. 2018. Peptide Amyloids in the Origin of Life. J. Mol. Biol. 20:3735-3750
Further literature will be indicated in the distributed script.
529-0432-00LPhysikalische Chemie IV: Magnetische Resonanz4 KP3GG. Jeschke, R. Riek
KurzbeschreibungTheoretische Grundlagen der magnetischen Resonanz (NMR, ESR) und ausgewählte Anwendungsbeispiele.
LernzielEinführung in die Grundlagen der magnetischen Resonanz in isotroper und anisotroper phase.
InhaltTheoretische und experimentelle Grundlagen der magnetischen Resonanz-Spektroskopie (Kernresonanz (NMR) und Elektronenspinresonanz (ESR)) in flüssiger und fester Phase. Klassische Beschreibung mittels der Bloch-Gleichungen, chemischer Austausch und zweidimensionale Exchange-Spektroskopie. Fourier-Spektroskopie, Echo-Phänomene und "Puls trickery". Interpretation der NMR Parameter wie chemische Verschiebung, skalare Kopplung und Dipolkopplung und Relaxationszeiten. Grundlagen der quantenmechanischen Beschreibung im Dichteoperatorformalismus. Die wichtigsten Wechselwirkungen in der magnetischen Resonanz in isotroper und anisotroper Phase und deren Hamilton-Operatoren. Anwendungen aus der Chemie, Biologie, Physik und Medizin, z.B. Ermittlung der dreidimensionalen Molekülstruktur, insbesondere von (biologischen) Makromolekülen, Bestimmung der Struktur von paramagnetischen Verbindungen, bildgebende NMR/MRI.
Skriptwird in der Vorlesung verteilt (in english)
529-0433-01LAdvanced Physical Chemistry: Statistical Thermodynamics6 KP3GR. Riek, J. Richardson
KurzbeschreibungIntroduction to statistical mechanics and thermodynamics. Prediction of thermodynamic and kinetic properties from molecular data.
LernzielIntroduction to statistical mechanics and thermodynamics. Prediction of thermodynamic and kinetic properties from molecular data.
InhaltBasics of statistical mechanics and thermodynamics of classical and quantum systems. Concept of ensembles, microcanonical and canonical ensembles, ergodic theorem. Molecular and canonical partition functions and their connection with classical thermodynamics. Quantum statistics. Translational, rotational, vibrational, electronic and nuclear spin partition functions of gases. Determination of the equilibrium constants and (transition-state theory) rates of gas phase reactions. Description of ideal gases and ideal crystals. Lattice models, mixing entropy of polymers, and entropic elasticity.
SkriptSee homepage of the lecture.
LiteraturSee homepage of the lecture.
Voraussetzungen / BesonderesChemical Thermodynamics, Reaction Kinetics, Molecular Quantum Mechanics and Spectroscopy; Mathematical Foundations (Analysis, Combinatorial Relations, Integral and Differential Calculus)
Fachspezifische KompetenzenKonzepte und Theoriengeprüft
Methodenspezifische KompetenzenAnalytische Kompetenzengeprüft
Soziale KompetenzenKommunikationgefördert
Persönliche KompetenzenKreatives Denkengeprüft
Kritisches Denkengeprüft
529-0499-00LPhysical Chemistry0 KP1KM. Reiher, A. Barnes, G. Jeschke, B. H. Meier, F. Merkt, J. Richardson, R. Riek, S. Riniker, T. Schmidt, R. Signorell, H. J. Wörner
KurzbeschreibungInstitute-Seminar covering current research Topics in Physical Chemistry
551-0357-00LCellular Matters: From Milestones to Open Questions
The number of participants is limited to 22 and will only take place with a minimum of 11 participants.
Please sign up until two weeks before the beginning of the semester (for Autumn 2022: by 05.09.2022 end of day) via e-mail to using in the subject: 551-0357-00. In the email body indicate 1) your name, 2) your e-mail address, 3) master/PhD program. The students admitted to this seminar will be informed by e-mail in the week prior to the beginning of the semester.

The first lecture will serve to form groups of students and assign papers.
4 KP2SY. Barral, F. Allain, P. Arosio, E. Dufresne, D. Hilvert, M. Jagannathan, R. Mezzenga, T. Michaels, G. Neurohr, R. Riek, A. E. Smith, K. Weis, H. Wennemers
KurzbeschreibungIn this course, the students will explore the quite new topic of biomolecular condensates.
Concepts and tools from biology, chemistry, biophysics and soft materials will be used, on one hand, to develop an understanding of the biological properties and functions of biomolecular condensates in health and disease, while, on the other, to inspire new materials.
LernzielIn terms of content, you, the student, after a general introduction to the topic, will learn about milestone works and current research questions in the young field of biomolecular condensates (properties, functions and applications) from an interdisciplinary point of view in a course which is a combination of literature (presentations given by pairs of students with different scientific backgrounds) and research seminars (presentations given by the lecturers all active experts in the field, with different backgrounds and expertise).
As to the skills, you will have the opportunity to learn how to critically read and evaluate scientific literature, how to give scientific presentations to an interdisciplinary audience (each presentation consisting of an introduction, critical description of the results and discussion of their significance) and substantiate your statements, acquire a critical mindset (pros/cons of chosen approaches/methods and limitations, quality of the data, solidity of the conclusions, possible follow-up experiments) that allows you to ask relevant questions and actively participate to the discussion.
With the final presentation you will have the unique opportunity to interact closely with the interdisciplinary group of lecturers (all internationally well-established experts) who will guide you in the choice of a subtopic and related literature.
InhaltIn the last decade a new kind of compartments within the cell, the so-called biomolecular condensates, have been observed. This discovery is radically changing our understanding of the cell, its organization and dynamics. The emerging picture is that the cytoplasm and nucleoplasm are highly complex fluids that can (meta)stably segregate into membrane-less sub-compartments, similarly to emulsions.

The topic of biomolecular condensates goes beyond the boundaries of traditional disciplines and needs a multi-pronged approach that levers on, and cross-fertilizes, biology, physical chemistry, biophysics and soft materials to develop a proper understanding of the properties, functions in health and disease (Alzheimer’s, Parkinson’s, etc.), as well as possible applications of these biomolecular condensates.

Each week the lecture will consist of:
1) a short literature seminar: Pairs of students from different scientific backgrounds will be formed and assigned beforehand to present milestone literature to the class and facilitate the ensuing discussion. In the first class the pairs will be formed, the milestone papers made known to the whole class and assigned to the pairs.
2) a research seminar: the presentation of the milestone literature will serve as the introduction to the lecture by one of the lecturers of the course on their own state-of-the-art research in the field.
SkriptThe presentations will be made available after the lectures.
LiteraturThe milestone papers will be provided in advance.
For the final examination, the students will be helped by the lecturers in identifying a research topic and related literature.
Fachspezifische KompetenzenKonzepte und Theoriengeprüft
Verfahren und Technologiengeprüft
Methodenspezifische KompetenzenAnalytische Kompetenzengeprüft
Medien und digitale Technologiengefördert
Soziale KompetenzenKommunikationgeprüft
Kooperation und Teamarbeitgeprüft
Menschenführung und Verantwortunggeprüft
Selbstdarstellung und soziale Einflussnahmegefördert
Sensibilität für Vielfalt gefördert
Persönliche KompetenzenAnpassung und Flexibilitätgefördert
Kreatives Denkengeprüft
Kritisches Denkengeprüft
Integrität und Arbeitsethikgefördert
Selbstbewusstsein und Selbstreflexion gefördert
Selbststeuerung und Selbstmanagement gefördert