Dario Neri: Catalogue data in Autumn Semester 2019 |
| Name | Prof. Dr. Dario Neri |
| Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 439 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +393351003074 |
| dario.neri@pharma.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Lecturer |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 535-0001-00L | Introduction to Pharmaceutical Sciences I | 2 credits | 2V | J. Hall, K.‑H. Altmann, A. Burden, M. Detmar, B. A. Gander, C. Halin Winter, J.‑C. Leroux, C. Müller, D. Neri, U. Quitterer, R. Schibli, G. Schneider, H. U. Zeilhofer | |
| Abstract | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
| Learning objective | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
| Content | Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields. | ||||
| Lecture notes | Handouts for individual lectures. | ||||
| Prerequisites / Notice | Interactive teaching | ||||
| 535-0011-00L | Drug Seminar  The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences | 5 credits | 9S | U. Quitterer, K.‑H. Altmann, S. M. Ametamey, A. Burden, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, D. Neri, V. I. Otto, R. Schibli, G. Schneider, C. Steuer | |
| Abstract | The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium. | ||||
| Learning objective | The main objectives of this course are: - students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic - students gain in-depth knowledge of the topic investigated - students train their scientific writing and presentation skills - students train their ability to plan a project and work in a team | ||||
| Content | The Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences. The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester. | ||||
| Prerequisites / Notice | Only for students of MSc Pharmacy and MSc Pharmaceutical Sciences. | ||||
| 535-0030-00L | Therapeutic Proteins | 3 credits | 3G | C. Halin Winter, D. Neri | |
| Abstract | In this course, various topics related to the development, GMP production and application of therapeutic proteins will be discussed. Furthermore, students will expand their training in pharmaceutical immunology and will be introduced to the basic concepts of pharmaceutical product quality management. | ||||
| Learning objective | Students know and understand: - basic mechanisms and regulation of the immune response - the pathogenic mechanisms of the most important immune-mediated disorders - the most frequently used expression systems for the production of therapeutic proteins - the use of protein engineering tools for modifying different features of therapeutic proteins - the mechanism of action of selected therapeutic proteins and their application - basic concepts in the GMP production of therapeutic proteins | ||||
| Content | The course consists of two parts: In a first part, students will complete their training of pharmaceutical immunology (Chapter 13 - 16 Immunobiology VIII textbook). This part particularly focuses on the pathogenic mechanisms of immune-mediated diseases. Deepened knowledge of immunology will be relevant for understanding the mechanism of action of many therapeutic proteins, as well as for understanding one major concern related to the use of protein-based drugs, namely, immunogenicity. The second part focuses on topics related to the development and application of therapeutic proteins, such as protein expression, protein engineering, reducing immunogenicity, and GMP production of therapeutic proteins. Furthermore, selected examples of approved therapeutic proteins will be discussed. | ||||
| Lecture notes | Handouts to the lectures will be available for downloading under http://www.pharma.ethz.ch/scripts/index | ||||
| Literature | - Janeway's ImmunoBiology, by Kenneth Murphy (9th Edition), Chapters 12-16 - Lecture Handouts - Paper References provided in the Scripts - EMEA Dossier for Humira | ||||
| 535-0239-00L | Practical Course in Medicinal Chemistry | 3 credits | 7P | J. Hall, M. Detmar, C. Halin Winter, D. Neri | |
| Abstract | The course comprises experiments relating to concepts of medicinal chemistry including statistical processing, fitting of experimental data, computer modeling of protein structures, experimental measurement of affinity constants and kinetic dissociation constants for protein ligands. The chemical stability of a drug will be studied. Basic gene cloning and protein expression will be introduced. | ||||
| Learning objective | Knowledge of experimental methods in drug discovery and development | ||||
| Content | Characterisation of the biophysical and biological properties of drugs. | ||||
| Lecture notes | Scripts | ||||
| Literature | Original literature | ||||
| Prerequisites / Notice | Requirements: Laboratory course in Pharmaceutical Anaytics; Lecture Medicinal Chemistry I in the same semester or earlier. | ||||
| 535-0810-00L | Gene Technology | 2 credits | 2G | D. Neri, C. Lizak | |
| Abstract | The course will provide a solid overview of the science and issues in gene technology and its pharmaceutical applications. | ||||
| Learning objective | The aim of the lecture course is to provide a solid overview of gene technology, with a special focus on drug development. Topics: Antibody phage technology, DNA-encoded chemistry, protein modification technology, genome sequencing, transcriptomics, proteomics, functional genomics, principle of drug discovery. The course is suited for advanced undergraduate and early graduate students in pharmaceutical sciences or related fields. | ||||
| Content | 1. Antibody phage technology The antibody molecule V genes, CDRs, basics of antibody engineering Principles of phage display Phagemid and phage vectors Antibody libraries Phage display selection methodologies Other phage libraries (peptides, globular proteins, enzymes) Alternative screening/selection methodologies DNA-encoded chemical libraries 2. Proteins: chemical modification and detection of biomolecular interactions Homo- and hetero-dimerization of proteins Chemical modifications of proteins Antibody-drug conjugates Radioactive labeling of proteins Kinetic association and dissociation constants Affinity constant: definition and its experimental measurement 3. Genomics: Applications to Human Biology Protein cloning and expression DNA sequencing Some foundations of genetic analysis Knock-out technologies Transcriptomics Proteomics Recombinant vaccines 4: Pharmaceuticals: Focus on Discovery Ligand Discovery Half-life extension Cancer therapy Gene therapy | ||||
| Lecture notes | Skript "Gene Technology" by Prof. Dario Neri and slides of the lecture | ||||
| 535-0830-00L | Pharmaceutical Immunology  | 2 credits | 2G | D. Neri, C. Halin Winter | |
| Abstract | Get Students familiar with basic Immunological concepts of pharmaceutical relevance. | ||||
| Learning objective | Get Students familiar with basic Immunological concepts of pharmaceutical relevance. | ||||
| Content | Chapters 1 - 11 of the Janeway's ImmunoBiology, by Kenneth Murphy (9th Edition; Garland). | ||||
| Literature | Janeway's ImmunoBiology, by Kenneth Murphy (9th Edition). Paperback [www.garlandscience.com] | ||||
| 535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, J.‑C. Leroux, D. Neri, U. Quitterer, G. Schneider, H. U. Zeilhofer | |
| Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | ||||
| Learning objective | State-of-the-art information on drug discovery and development. | ||||
| Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | ||||
| 535-1001-00L | Laboratory Course General Chemistry (for Biology and Pharmacy) Information about the practical course will be given on the first day. | 6 credits | 8P | R. O. Kissner, K.‑H. Altmann, J. Hall, D. Neri, M. D. Wörle | |
| Abstract | Introduction to the practical work in a chemistry laboratory. The most important manipulations and techniques are treated, as well as the the most fundamental chemical reaction types. | ||||
| Learning objective | - Knowledge of the basic chemical laboratory methods. - Basic knowledge of the scientific approach in experimenting. - Observation and interpretation of real-world chemical processes. - Keeping of a reliable laboratory journal. | ||||
| Content | - Simple chemical methods and calculations. - Separation techniques. - Physical measurements: mass, volume, pH, optical spectra. - Ionic solids (salts). - Acid/base chemistry, buffers. - Redox reactions. - Metal complexes. - Titration methods and quantitative spectrometry. - Introduction to qualitative analysis. | ||||
| Lecture notes | Course manual in German (is handed out to the students at the begin of the lessons). Language: German, English upon request. PDF files available at http://acac1.ethz.ch/praktikum/docs.html Accessible in intranet, by WLAN after login or through VPN | ||||
| Literature | Basic Concepts of Chemistry, International Student Version, 8th Edition, Leo J. Malone, Theodore Dolter Wiley is a suitable textbook. | ||||
| Prerequisites / Notice | This practical course causes costs for materials and chemicals. The costs are charged to the students at the end of semester. | ||||