Uwe Sauer: Katalogdaten im Frühjahrssemester 2020 |
| Name | Herr Prof. Dr. Uwe Sauer |
| Lehrgebiet | Systembiologie |
| Adresse | Inst. f. Molekulare Systembiologie ETH Zürich, HPM H 28 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND |
| Telefon | +41 44 633 36 72 |
| sauer@imsb.biol.ethz.ch | |
| Departement | Biologie |
| Beziehung | Ordentlicher Professor |
| Nummer | Titel | ECTS | Umfang | Dozierende | |
|---|---|---|---|---|---|
| 551-0001-AAL | General Biology I Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen. | 3 KP | 6R | U. Sauer, O. Y. Martin, A. Widmer | |
| Kurzbeschreibung | Organismic biology to teach the basic principles of classical and molecular genetics, evolutionary biology and phylogeny. First in a series of two lectures given over two semesters for students of agricultural and food sciences, as well as of environmental sciences. | ||||
| Lernziel | The understanding of basic principles of biology (inheritance, evolution and phylogeny) and an overview of the diversity of life. | ||||
| Inhalt | The first semester focuses on the organismal biology aspects of genetics, evolution and diversity of life in the Campbell chapters 12-34. Week 1-7 by Alex Widmer, Chapters 12-25 12 Cell biology Mitosis 13 Genetics Sexual life cycles and meiosis 14 Genetics Mendelian genetics 15 Genetics Linkage and chromosomes 20 Genetics Evolution of genomes 21 Evolution How evolution works 22 Evolution Phylogentic reconstructions 23 Evolution Microevolution 24 Evolution Species and speciation 25 Evolution Macroevolution Week 8-14 by Oliver Martin, Chapters 26-34 26 Diversity of Life Introdution to viruses 27 Diversity of Life Prokaryotes 28 Diversity of Life Origin & evolution of eukaryotes 29 Diversity of Life Nonvascular&seedless vascular plants 30 Diversity of Life Seed plants 31 Diversity of Life Introduction to fungi 32 Diversity of Life Overview of animal diversity 33 Diversity of Life Introduction to invertebrates 34 Diversity of Life Origin & evolution of vertebrates | ||||
| Skript | No script | ||||
| Literatur | Campbell et al. (2018) Biology - A Global Approach. 11th Edition (Global Edition | ||||
| Voraussetzungen / Besonderes | This is a virtual self-study lecture for non-german speakers of the "Allgemeine Biology I (551-0001-00L) lecture. The exam will be written jointly with the participants of this lecture. Example exam questions will be discussed during the lectures, and old exam questions are kept by the various student organisations. If necessary, please contact Prof. Uwe Sauer (sauer@ethz.ch) for details regarding the exam. | ||||
| 551-0002-00L | Allgemeine Biologie II  | 4 KP | 4G | U. Sauer, K. Bomblies, O. Y. Martin | |
| Kurzbeschreibung | Grundlagen der Biochemie (Makromoleküle, Membranen, Zellstrukturen, Stoffwechsel) Molekulargenetik (Genexpression und Regulation, vom Gen zum Protein) Physiologie höherer Pflanzen (Struktur, Wachstum, Entwicklung, Nährstoffe, Transport und Reproduktion) | ||||
| Lernziel | Verständnis grundlegender Konzepte molekularer Biologie und Physiologie. | ||||
| Inhalt | Zellluläre Funktionen auf der Ebenen von Molekülen und Strukturen. Molekulare Vorgänge in der Prozessierung vom Gen zum Protein. Pflanzenphysiologie. Die folgenden Campbell Kapitel werden behandelt: Woche 1-5: 5 Biological macromolecules and lipids 7 Cell structure and function 8 Cell membranes 10 Respiration: introduction to metabolism 10 Cell respiration 11 Photosynthetic processes Woche 6-9: 16 Nucleic acids and inheritance 17 Expression of genes 18 Control of gene expression 19 DNA Technology Woche 9-13: 35 Plant Structure and Growth 36 Transport in vascular plants 37 Plant nutrition 38 Reproduction of flowering plants 39 Plants signal and behavior | ||||
| Skript | Kein Skript | ||||
| Literatur | Campbell, Reece et al: "Biologie" (11th global edition); Pearson 2018. | ||||
| 551-0003-AAL | General Biology I+II Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle andere Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen. | 7 KP | 13R | U. Sauer, K. Bomblies, O. Y. Martin, A. Widmer | |
| Kurzbeschreibung | General Biology I: Organismic biology to teach the basic principles of classical and molecular genetics, evolutionary biology and phylogeny. General Biology II: Molecular biology approach to teach the basic principles of biochemistry, cell biology, cgenetics, evolutionary biology and form and function of vacular plants. | ||||
| Lernziel | General Biology I: The understanding of basic principles of biology (inheritance, evolution and phylogeny) and an overview of the diversity of life. General Biology II: The understanding basic concepts of biology: the hierarchy of the structural levels of biological organisation, with particular emphasis on the cell and its molecular functions, the fundamentals of metabolism and molecular genetics, as well as form and function of vascular plants. | ||||
| Inhalt | General Biology I: General Biology I focuses on the organismal biology aspects of genetics, evolution and diversity of life in the Campbell chapters 12-34. Week 1-7 by Alex Widmer, Chapters 12-25 12 Cell biology Mitosis 13 Genetics Sexual life cycles and meiosis 14 Genetics Mendelian genetics 15 Genetics Linkage and chromosomes 20 Genetics Evolution of genomes 21 Evolution How evolution works 22 Evolution Phylogentic reconstructions 23 Evolution Microevolution 24 Evolution Species and speciation 25 Evolution Macroevolution Week 8-14 by Oliver Martin, Chapters 26-34 26 Diversity of Life Introdution to viruses 27 Diversity of Life Prokaryotes 28 Diversity of Life Origin & evolution of eukaryotes 29 Diversity of Life Nonvascular&seedless vascular plants 30 Diversity of Life Seed plants 31 Diversity of Life Introduction to fungi 32 Diversity of Life Overview of animal diversity 33 Diversity of Life Introduction to invertebrates 34 Diversity of Life Origin & evolution of vertebrates General Biology II: The structure and function of biomacromolecules; basics of metabolism; tour of the cell; membrane structure and function; basic energetics of cellular processes; respiration, photosynthesis; cell cycle, from gene to protein; structure and growth of vascular plants, resource acquisition and transport, soil and plant nutrition. Specifically the following Campbell chapters will be covered: 3 Biochemistry Chemistry of water 4 Biochemistry Carbon: the basis of molecular diversity 5 Biochemistry Biological macromolecules and lipids 7 Cell biology Cell structure and function 8 Cell biology Cell membranes 10 Cell biology Respiration: introduction to metabolism 10 Cell biology Cell respiration 11 Cell biology Photosynthetic processes 16 Genetics Nucleic acids and inheritance 17 Genetics Expression of genes 18 Genetics Control of gene expression 19 Genetics DNA Technology 35 Plant structure&function Plant Structure and Growth 36 Plant structure&function Transport in vascular plants 37 Plant structure&function Plant nutrition 38 Plant structure&function Reproduction of flowering plants 39 Plant structure&function Plants signal and behavior | ||||
| Skript | No script | ||||
| Literatur | Campbell et al. (2018) Biology - A Global Approach. 11th Edition (Global Edition) | ||||
| Voraussetzungen / Besonderes | Basic general and organic chemistry This is a virtual self-study lecture for non-German speakers of the "Allgemeine Biology I (551-0001-00L) and "Allgemeine Biology II (551-0002-00L) lectures. The exam will be written jointly with the participants of this lecture. | ||||
| 551-0324-00L | Systems Biology  | 6 KP | 4V | P. Picotti, M. Claassen, U. Sauer, B. Snijder, B. Wollscheid | |
| Kurzbeschreibung | Introduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects. | ||||
| Lernziel | - obtain an overview of global analytical methods - obtain an overview of computational methods in systems biology - understand the concepts of systems biology | ||||
| Inhalt | Overview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology. | ||||
| Skript | no script | ||||
| Literatur | The course is not taught by a particular book, but some books are suggested for further reading: - Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005 | ||||
| 551-0342-00L | Metabolomics Number of participants limited to 15. The enrolment is done by the D-BIOL study administration. | 6 KP | 7G | N. Zamboni, U. Sauer | |
| Kurzbeschreibung | The course covers all basic aspects of metabolome measurements, from sample sampling to mass spectrometry and data analysis. Participants work in groups and independently perform and interpret metabolomic experiments. | ||||
| Lernziel | Performing and reporting a metabolomic experiment, understanding pro and cons of mass spectrometry based metabolomics. Knowledge of workflows and tools to assist experiment interpretation, and metabolite identification. | ||||
| Inhalt | Basics of metabolomics: workflows, sample preparation, targeted and untargeted mass spectrometry, instrumentation, separation techniques (GC, LC, CE), metabolite identification, data interpretation and integration, normalization, QCs, maintenance. Soft skills to be trained: project planning, presentation, reporting, independent working style, team work. | ||||
| 551-1174-00L | Systembiologie | 4 KP | 2V + 2U | U. Sauer, K. M. Borgwardt, J. Stelling, N. Zamboni | |
| Kurzbeschreibung | Ausgehend von biologischen Fragen und Phänomenen unterrichtet der Kurs zur Beantwortung notwendige Konzepte von Modellierungen und Datenanalysen. In den Übungen erhalten die Studenten erste praktische Erfahrungen in einfacher Programmierung eigener Modelle und Analysen. | ||||
| Lernziel | Wir unterrichten kein oder nur wenig neues biologisches Wissen oder experimentelle Analysemethoden, sondern nutzen aus dem Studium bekanntes Wissen (z. B. Enzymkinetik, Regulationsmechanismen oder analytische Methoden). Unser Ziel ist es biologische Probleme aufzuzeigen, die aus dynamischen Interaktionen molekularer Elemente entstehen und mit Hilfe von Computermethoden gelöst werden können. Spezifische Ziele sind: - Verständnis der Limitationen intuitiver Argumentation in der Biologie - Ein erster Überblick über Computermethoden in der Systembiologie - Übersetzen biologischer Fragestellungen in computerlösbare Probleme - Praktische Erfahrungen in Programmierung mit MATLAB - Erste Erfahrungen in der Computerinterprätation von biologischen Daten - Verständnis typischer Abstraktionen in der Modellierung molekularer Systeme | ||||
| Inhalt | Während der ersten 7 Wochen konzentrieren wir uns auf mechanistische Modellierungen. Ausgehend von einfachen Enzymkinetiken betrachten wir zunächst die Dynamik von kleinerer Stoffwechselwegen und enden mit stöchiometrischen Modellen mittlerer Netzwerke. In der zweiten Kurshälfte konzentrieren wir uns auf die Analyse von typischen biologischen Omics Datensätzen. Wir starten mit multivariaten statistischen Methoden wie z. B. Clustering und Principal Component Analysis und enden mit Methoden um Netzwerke aus Daten zu lernen. | ||||
| Skript | Skripten zur Vorbereitung werden per Moodle zur Verfügung gestellt | ||||
| Literatur | Der Kurs wird nicht mit einem bestimmten Lehrbuch unterrichtet, aber 2 Bücher werden zur Unterstützung empfohlen: - Systems Biology (Klipp, Herwig, Kowald, Wierling und Lehrach) Wiley-VCH 2009 - A First Course in Systems Biology (Eberhardt O. Voight) Garland Science 2012 | ||||