Uwe Sauer: Katalogdaten im Frühjahrssemester 2017

NameHerr Prof. Dr. Uwe Sauer
LehrgebietSystembiologie
Adresse
Inst. f. Molekulare Systembiologie
ETH Zürich, HPM H 28
Otto-Stern-Weg 3
8093 Zürich
SWITZERLAND
Telefon+41 44 633 36 72
E-Mailsauer@imsb.biol.ethz.ch
DepartementBiologie
BeziehungOrdentlicher Professor

NummerTitelECTSUmfangDozierende
551-0001-AALGeneral Biology I
Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben.

Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen.
3 KP6RU. Sauer, O. Y. Martin, A. Widmer
KurzbeschreibungOrganismic biology to teach the basic principles of classical and molecular genetics, evolutionary biology and phylogeny.
First in a series of two lectures given over two semesters for students of agricultural and food sciences, as well as of environmental sciences.
LernzielThe understanding of basic principles of biology (inheritance, evolution and phylogeny) and an overview of the diversity of life.
InhaltThe first semester focuses on the organismal biology aspects of genetics, evolution and diversity of life in the Campbell chapters 12-34.

Week 1-7 by Alex Widmer, Chapters 12-25
12 Cell biology Mitosis
13 Genetics Sexual life cycles and meiosis
14 Genetics Mendelian genetics
15 Genetics Linkage and chromosomes
20 Genetics Evolution of genomes
21 Evolution How evolution works
22 Evolution Phylogentic reconstructions
23 Evolution Microevolution
24 Evolution Species and speciation
25 Evolution Macroevolution

Week 8-14 by Oliver Martin, Chapters 26-34
26 Diversity of Life Introdution to viruses
27 Diversity of Life Prokaryotes
28 Diversity of Life Origin & evolution of eukaryotes
29 Diversity of Life Nonvascular&seedless vascular plants
30 Diversity of Life Seed plants
31 Diversity of Life Introduction to fungi
32 Diversity of Life Overview of animal diversity
33 Diversity of Life Introduction to invertebrates
34 Diversity of Life Origin & evolution of vertebrates
SkriptNo script
LiteraturCampbell et al. (2015) Biology - A Global Approach. 10th Edition (Global Edition
551-0002-AALGeneral Biology II
Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben.

Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen.
4 KP6RU. Sauer, R. Aebersold, W. Gruissem
KurzbeschreibungBasics of biochemistry (macromolecules, membranes, cellular structures, metabolism), molecular genetics (gene expression and its regulation; from gene to protein), and physiology of higher plants (structure, growth, development, nutrition, transport, reproduction)
LernzielThe understanding of basic concepts of molecular biology and physiology.
InhaltHow cells function at the level of molecules and higher structures.
Molecular processes during gene expression.
Plant physiology.

The following Campbell chapters will be covered:

Week 1-5: Prof. Sauer
5 Biological macromolecules and lipids
7 Cell structure and function
8 Cell membranes
10 Respiration: introduction to metabolism
10 Cell respiration
11 Photosynthetic processes

Week 6-9: Prof. Aebersold
16 Nucleic acids and inheritance
17 Expression of genes
18 Control of gene expression
19 DNA Technology

Week 9-13: Prof. Gruissem
35 Plant Structure and Growth
36 Transport in vascular plants
37 Plant nutrition
38 Reproduction of flowering plants
39 Plants signal and behavior
SkriptNo script
LiteraturCampbell, Reece et al: "Biologie" (10th global edition); Pearson 2015.
Voraussetzungen / BesonderesBasic general and organic chemistry
551-0002-00LAllgemeine Biologie II Belegung eingeschränkt - Details anzeigen 4 KP4GU. Sauer, R. Aebersold, W. Gruissem
KurzbeschreibungGrundlagen der
Biochemie (Makromoleküle, Membranen, Zellstrukturen, Stoffwechsel)
Molekulargenetik (Genexpression und Regulation, vom Gen zum Protein)
Physiologie höherer Pflanzen (Struktur, Wachstum, Entwicklung, Nährstoffe, Transport und Reproduktion)
LernzielVerständnis grundlegender Konzepte molekularer Biologie und Physiologie.
InhaltZellluläre Funktionen auf der Ebenen von Molekülen und Strukturen.
Molekulare Vorgänge in der Prozessierung vom Gen zum Protein.
Pflanzenphysiologie.

Die folgenden Campbell Kapitel werden behandelt:

Woche 1-5: Prof. Sauer
5 Biological macromolecules and lipids
7 Cell structure and function
8 Cell membranes
10 Respiration: introduction to metabolism
10 Cell respiration
11 Photosynthetic processes

Woche 6-9: Prof. Aebersold
16 Nucleic acids and inheritance
17 Expression of genes
18 Control of gene expression
19 DNA Technology

Woche 9-13: Prof. Gruissem
35 Plant Structure and Growth
36 Transport in vascular plants
37 Plant nutrition
38 Reproduction of flowering plants
39 Plants signal and behavior
SkriptKein Skript
LiteraturCampbell, Reece et al: "Biologie" (10th global edition); Pearson 2015.
551-0324-00LSystems Biology6 KP4VR. Aebersold, B. Christen, M. Claassen, E. Hafen, U. Sauer
KurzbeschreibungIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Lernziel- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
InhaltOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Skriptno script
LiteraturThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
551-0342-00LMetabolomics Belegung eingeschränkt - Details anzeigen
Number of participants limited to 15.

The enrolment is done by the D-BIOL study administration.
6 KP7GN. Zamboni, U. Sauer
KurzbeschreibungThe course covers all basic aspects of metabolome measurements, from sample sampling to mass spectrometry and data analysis. Participants work in groups and independently perform and interpret metabolomic experiments.
LernzielPerforming and reporting a metabolomic experiment, understanding pro and cons of mass spectrometry based metabolomics. Knowledge of workflows and tools to assist experiment interpretation, and metabolite identification.
InhaltBasics of metabolomics: workflows, sample preparation, targeted and untargeted mass spectrometry, instrumentation, separation techniques (GC, LC, CE), metabolite identification, data interpretation and integration, normalization, QCs, maintenance.

Soft skills to be trained: project planning, presentation, reporting, independent working style, team work.
551-1174-00LSystembiologie4 KP2V + 2UU. Sauer, K. M. Borgwardt, J. Stelling, N. Zamboni
KurzbeschreibungThe course teaches computational methods and first hands-on applications by starting from biological problems/phenomena that students in the 4th semester are somewhat familiar with. During the exercises, students will obtain first experience with programming their own analyses/models for data analysis/interpretation.
LernzielWe will teach little if any novel biological knowledge or analysis methods, but focus on training the ability of use existing knowledge (for example from enzyme kinetics, regulatory mechanisms or analytical methods) to understand biological problems that arise when considering molecular elements in their context and to translate some of these problems into a form that can be solved by computational methods. Specific goals are:
- understand the limitations of intuitive reasoning
- obtain a first overview of computational approaches in systems biology
- train ability to translate biological problems into computational problems
- solve practical problems by programming with MATLAB
- make first experiences in computational interpretation of biological data
- understand typical abstractions in modeling molecular systems
InhaltDuring the first 7 weeks, the will focus on mechanistic modeling. Starting from simple enzyme kinetics, we will move through the dynamics of small pathways that also include regulation and end with flux balance analysis of a medium size metabolic network. During the second 7 weeks, the focus will shift to the analysis of larger data sets, such as metabolomics and transcriptomics that are often generated in biology. Here we will go through multivariate statistical methods that include clustering and principal component analysis, ending with first methods to learn networks from data.
SkriptNo script
LiteraturThe course is not taught by a particular book, but two books are suggested for further reading:
- Systems Biology (Klipp, Herwig, Kowald, Wierling und Lehrach) Wiley-VCH 2009
- A First Course in Systems Biology (Eberhardt O. Voight) Garland Science 2012