Uwe Sauer: Katalogdaten im Frühjahrssemester 2017 |
Name | Herr Prof. Dr. Uwe Sauer |
Lehrgebiet | Systembiologie |
Adresse | Inst. f. Molekulare Systembiologie ETH Zürich, HPM H 28 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND |
Telefon | +41 44 633 36 72 |
sauer@imsb.biol.ethz.ch | |
Departement | Biologie |
Beziehung | Ordentlicher Professor |
Nummer | Titel | ECTS | Umfang | Dozierende | |
---|---|---|---|---|---|
551-0001-AAL | General Biology I Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen. | 3 KP | 6R | U. Sauer, O. Y. Martin, A. Widmer | |
Kurzbeschreibung | Organismic biology to teach the basic principles of classical and molecular genetics, evolutionary biology and phylogeny. First in a series of two lectures given over two semesters for students of agricultural and food sciences, as well as of environmental sciences. | ||||
Lernziel | The understanding of basic principles of biology (inheritance, evolution and phylogeny) and an overview of the diversity of life. | ||||
Inhalt | The first semester focuses on the organismal biology aspects of genetics, evolution and diversity of life in the Campbell chapters 12-34. Week 1-7 by Alex Widmer, Chapters 12-25 12 Cell biology Mitosis 13 Genetics Sexual life cycles and meiosis 14 Genetics Mendelian genetics 15 Genetics Linkage and chromosomes 20 Genetics Evolution of genomes 21 Evolution How evolution works 22 Evolution Phylogentic reconstructions 23 Evolution Microevolution 24 Evolution Species and speciation 25 Evolution Macroevolution Week 8-14 by Oliver Martin, Chapters 26-34 26 Diversity of Life Introdution to viruses 27 Diversity of Life Prokaryotes 28 Diversity of Life Origin & evolution of eukaryotes 29 Diversity of Life Nonvascular&seedless vascular plants 30 Diversity of Life Seed plants 31 Diversity of Life Introduction to fungi 32 Diversity of Life Overview of animal diversity 33 Diversity of Life Introduction to invertebrates 34 Diversity of Life Origin & evolution of vertebrates | ||||
Skript | No script | ||||
Literatur | Campbell et al. (2015) Biology - A Global Approach. 10th Edition (Global Edition | ||||
551-0002-AAL | General Biology II Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen. | 4 KP | 6R | U. Sauer, R. Aebersold, W. Gruissem | |
Kurzbeschreibung | Basics of biochemistry (macromolecules, membranes, cellular structures, metabolism), molecular genetics (gene expression and its regulation; from gene to protein), and physiology of higher plants (structure, growth, development, nutrition, transport, reproduction) | ||||
Lernziel | The understanding of basic concepts of molecular biology and physiology. | ||||
Inhalt | How cells function at the level of molecules and higher structures. Molecular processes during gene expression. Plant physiology. The following Campbell chapters will be covered: Week 1-5: Prof. Sauer 5 Biological macromolecules and lipids 7 Cell structure and function 8 Cell membranes 10 Respiration: introduction to metabolism 10 Cell respiration 11 Photosynthetic processes Week 6-9: Prof. Aebersold 16 Nucleic acids and inheritance 17 Expression of genes 18 Control of gene expression 19 DNA Technology Week 9-13: Prof. Gruissem 35 Plant Structure and Growth 36 Transport in vascular plants 37 Plant nutrition 38 Reproduction of flowering plants 39 Plants signal and behavior | ||||
Skript | No script | ||||
Literatur | Campbell, Reece et al: "Biologie" (10th global edition); Pearson 2015. | ||||
Voraussetzungen / Besonderes | Basic general and organic chemistry | ||||
551-0002-00L | Allgemeine Biologie II | 4 KP | 4G | U. Sauer, R. Aebersold, W. Gruissem | |
Kurzbeschreibung | Grundlagen der Biochemie (Makromoleküle, Membranen, Zellstrukturen, Stoffwechsel) Molekulargenetik (Genexpression und Regulation, vom Gen zum Protein) Physiologie höherer Pflanzen (Struktur, Wachstum, Entwicklung, Nährstoffe, Transport und Reproduktion) | ||||
Lernziel | Verständnis grundlegender Konzepte molekularer Biologie und Physiologie. | ||||
Inhalt | Zellluläre Funktionen auf der Ebenen von Molekülen und Strukturen. Molekulare Vorgänge in der Prozessierung vom Gen zum Protein. Pflanzenphysiologie. Die folgenden Campbell Kapitel werden behandelt: Woche 1-5: Prof. Sauer 5 Biological macromolecules and lipids 7 Cell structure and function 8 Cell membranes 10 Respiration: introduction to metabolism 10 Cell respiration 11 Photosynthetic processes Woche 6-9: Prof. Aebersold 16 Nucleic acids and inheritance 17 Expression of genes 18 Control of gene expression 19 DNA Technology Woche 9-13: Prof. Gruissem 35 Plant Structure and Growth 36 Transport in vascular plants 37 Plant nutrition 38 Reproduction of flowering plants 39 Plants signal and behavior | ||||
Skript | Kein Skript | ||||
Literatur | Campbell, Reece et al: "Biologie" (10th global edition); Pearson 2015. | ||||
551-0324-00L | Systems Biology | 6 KP | 4V | R. Aebersold, B. Christen, M. Claassen, E. Hafen, U. Sauer | |
Kurzbeschreibung | Introduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects. | ||||
Lernziel | - obtain an overview of global analytical methods - obtain an overview of computational methods in systems biology - understand the concepts of systems biology | ||||
Inhalt | Overview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology. | ||||
Skript | no script | ||||
Literatur | The course is not taught by a particular book, but some books are suggested for further reading: - Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005 | ||||
551-0342-00L | Metabolomics Number of participants limited to 15. The enrolment is done by the D-BIOL study administration. | 6 KP | 7G | N. Zamboni, U. Sauer | |
Kurzbeschreibung | The course covers all basic aspects of metabolome measurements, from sample sampling to mass spectrometry and data analysis. Participants work in groups and independently perform and interpret metabolomic experiments. | ||||
Lernziel | Performing and reporting a metabolomic experiment, understanding pro and cons of mass spectrometry based metabolomics. Knowledge of workflows and tools to assist experiment interpretation, and metabolite identification. | ||||
Inhalt | Basics of metabolomics: workflows, sample preparation, targeted and untargeted mass spectrometry, instrumentation, separation techniques (GC, LC, CE), metabolite identification, data interpretation and integration, normalization, QCs, maintenance. Soft skills to be trained: project planning, presentation, reporting, independent working style, team work. | ||||
551-1174-00L | Systembiologie | 4 KP | 2V + 2U | U. Sauer, K. M. Borgwardt, J. Stelling, N. Zamboni | |
Kurzbeschreibung | The course teaches computational methods and first hands-on applications by starting from biological problems/phenomena that students in the 4th semester are somewhat familiar with. During the exercises, students will obtain first experience with programming their own analyses/models for data analysis/interpretation. | ||||
Lernziel | We will teach little if any novel biological knowledge or analysis methods, but focus on training the ability of use existing knowledge (for example from enzyme kinetics, regulatory mechanisms or analytical methods) to understand biological problems that arise when considering molecular elements in their context and to translate some of these problems into a form that can be solved by computational methods. Specific goals are: - understand the limitations of intuitive reasoning - obtain a first overview of computational approaches in systems biology - train ability to translate biological problems into computational problems - solve practical problems by programming with MATLAB - make first experiences in computational interpretation of biological data - understand typical abstractions in modeling molecular systems | ||||
Inhalt | During the first 7 weeks, the will focus on mechanistic modeling. Starting from simple enzyme kinetics, we will move through the dynamics of small pathways that also include regulation and end with flux balance analysis of a medium size metabolic network. During the second 7 weeks, the focus will shift to the analysis of larger data sets, such as metabolomics and transcriptomics that are often generated in biology. Here we will go through multivariate statistical methods that include clustering and principal component analysis, ending with first methods to learn networks from data. | ||||
Skript | No script | ||||
Literatur | The course is not taught by a particular book, but two books are suggested for further reading: - Systems Biology (Klipp, Herwig, Kowald, Wierling und Lehrach) Wiley-VCH 2009 - A First Course in Systems Biology (Eberhardt O. Voight) Garland Science 2012 |