Carlo Thilgen: Catalogue data in Autumn Semester 2022 |
| Name | Prof. Dr. Carlo Thilgen |
| Address | Lab. für Organische Chemie ETH Zürich, HCI G 317 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 632 29 35 |
| thilgen@org.chem.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Adjunct Professor |
| Number | Title | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 529-0229-00L | Practical Course Organic Chemistry (for Students of Biology and Pharmaceutical Sciences)  Latest online enrolment is 10 days before the beginning of the semester. Students who did not pass the first-year examinations need the lecturers' written permission to take this course. | 8 credits | 12P | C. Thilgen, Y. Yamakoshi | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Analytical part: basic operations for the separation of mixtures of organic compounds (recrystallization, distillation, extraction, chromatography) Synthetic part (main part): at least 8 synthetic steps (one- or two-step syntheses). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Learn the basic techniques for the preparation and purification of organic compounds. Learn to take accurate notes of the experiments and to write reports. Deepen the understanding of reaction mechanisms. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Analytical part: basic operations for the separation of mixtures of organic compounds (recrystallization, distillation, extraction, chromatography). Synthetic part (main part): at least 8 synthetic steps (one- or two-step syntheses) from the following classes of reactions: 1. nucleophilic substitution at C(sp3), 2. elimination or electrophilic addition to C=C, 3. electrophilic aromatic substitution, 4. oxidation, 5. reduction, 6. Grignard reaction, 7. synthesis of a carboxylic acid derivative, 8. Aldol-, Claisen-, Mannich-, Michael reaction or Robinson annulation. Introduction to database searches (Reaxys, SciFinder). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Documentation will be handed out at the beginning of the course. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | 1) P. Wörfel, M. Bitzer, U. Claus, H. Felber, M. Hübel, B. Vollenweider, Laborpraxis (Bd. 1: Einführung, allgemeine Methoden; Bd. 2: Messmethoden; Bd. 3: Trennungsmethoden; Bd. 4: Analytische Methoden); Birkhäuser Verlag; Basel; 1990. 2) J. Leonard, B. Lygo, G. Procter; Advanced Practical Organic Chemistry; CRC Press Taylor & Francis Group; Boca Raton, FL; 2013. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | The basic reactions of Organic Chemistry and their mechanisms should be known and the corresponding exam have been passed (cf. course 529-1012-00L Organic Chemistry II for Students of Biology, Pharmaceutical Sciences, and Health Sci. and Tech.). As a prerequisite, all participants need to pass the "Safety Test HCI Chemie_V2 English" (see https://moodle-app2.let.ethz.ch). A printout of the certificate generated by the system needs to be presented to the teaching assistants prior to starting lab work. Safety concept: https://chab.ethz.ch/studium/bachelor1.html | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Competencies |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0810-01L | Laboratory Course Organic Chemistry II - Admittance is limited and depends on the availability of hosting research labs. - Interested students are asked to contact Prof. C. Thilgen (thilgen@org.chem.ethz.ch) before the end of the preceding semester for further details. - In case of admittance, the actual enrolment needs to be done via the D-BIOL study administration. | 12 credits | 14P | C. Thilgen | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | An organic-synthetic sub-project of the current research of a group from the Laboratory of Organic Chemistry is carried out under the guidance of doctoral students. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Learn to plan and carry out challenging multistep syntheses making use of modern methods; reach a deeper understanding of organic reactions through experimental work; develop an organic-synthetic research project; take accurate notes, write a publication style report, and present the obtained results in a seminar. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | An organic-synthetic sub-project of the current research of a group from the Laboratory of Organic Chemistry is carried out under the guidance of doctoral students. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | No course notes. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | No set textbooks. Literature will be indicated or provided by the supervising TAs. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Course prerequisites: Accomplished laboratory course Organic Chemistry I (529-0229-00 or 529-0016-00) and passed session exams Organic Chemistry I (529-0221-00 or 529-1011-00) / Organic Chemistry II (529-0222-00 or 529-1012-00). The number of participants per course is limited to 4. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-1011-00L | Organic Chemistry I (for Biol./Pharm.Sc./HST) | 4 credits | 4G | C. Thilgen | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Fundamentals of Organic Chemistry: molecular structure. Bonding and functional groups; nomenclature; resonance and aromaticity; stereochemistry; conformation; bond strength; organic acids and bases; basic reaction thermodynamics and kinetcs; reactive intermediates: carbanions, carbenium ions and radicals. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding the basic concepts and definitions of organic chemistry. Knowledge of the functional groups and classes of compounds that are important in biological systems. Foundations for the understanding of the relationship between structure and reactivity. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Organic molecules: Isolation, separation and characterization of organic compounds. Classical structure theory: constitution, covalent bonding, bonding geometry, functional groups, classes of compounds, nomenclature. Electron delocalization: resonance, aromaticity. Stereochemistry: chirality, configuration, topicity. Conformational analysis. Bond energies, non-covalent interactions. Organic acids and bases. Basic reaction thermodynamics and kinetcs; reactive intermediates: carbanions, carbenium ions and radicals. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Printed lecture notes are available. Exercises, answer keys and other handouts can be downloaded from the Moodle course "Organic Chemistry I" of the current semester (https://moodle-app2.let.ethz.ch). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | · Basisbuch Organische Chemie. Carsten Schmuck, Pearson Studium, 2018. (Kompaktes Lehrbuch für die ersten beiden Semester; 412 Seiten). · Organische Chemie. K. Peter C. Vollhardt, Neil E. Schore, Übers. hrsg. von Holger Butenschön, 6. Aufl., Wiley-VCH, 2020. · Organic Chemistry: Structure and Function. K. Peter C. Vollhardt, Neil E. Schore, 8th ed., W. H. Freeman & Company, 2018. · Organic Chemistry. T. W. Graham Solomons, Craig B. Fryhle, Scott A. Snyder, 12th ed., Wiley, 2016. · Organische Chemie. J. Clayden, N. Greeves, S. Warren, 2. Aufl., Springer Berlin, 2017 (Korr. Nachdr. 2. Auflage 2013). · Organic Chemistry. J. Clayden, N. Greeves, S. Warren, 2nd ed., Oxford University Press, 2012. · Organische Chemie. Paula Y. Bruice, 5. akt. Aufl., Pearson Studium, 2011. · Organic Chemistry. Paula Y. Bruice, 8th ed., Pearson, 2016. · Essential Organic Chemistry. Paula Y. Bruice, 3rd ed., Pearson, 2015. (Designed for a one-term course) · Organic Chemistry I as a Second Language – Translating the basic concepts (Taschenbuch mit Übungen: 400 Seiten). David R. Klein; 4th ed., Wiley, 2016. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | The course consists of lectures (36 hours) and problem-solving lessons (20 hours, groups of ca. 25 people). In addition, online exercises are available in the e-learning environment Moodle (Course OC I). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||