Renato Zenobi: Catalogue data in Spring Semester 2020 |  |
| Name | Prof. Dr. Renato Zenobi |
| Field | Analytische Chemie |
| Address | Lab. für Organische Chemie ETH Zürich, HCI E 329 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 632 43 76 |
| Fax | +41 44 632 12 92 |
| renato.zenobi@org.chem.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 529-0051-AAL | Analytical Chemistry I Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. All other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 3 credits | 6R | D. Günther, R. Zenobi | |
| Abstract | Introduction into the most important spectroscopical methods and their applications to gain structural information. | ||||
| Learning objective | Knowledge about the necessary theoretical background of spectroscopical methods and their practical applications | ||||
| Content | Application oriented basics of organic and inorganic instrumental analysis and of the empirical employment of structure elucidation methods: Mass spectrometry: Ionization methods, mass separation, isotope signals, rules of fragmentation, rearrangements. NMR spectroscopy: Experimental basics, chemical shift, spin-spin coupling. IR spectroscopy: Revisiting topics like harmonic oscillator, normal vibrations, coupled oscillating systems (in accordance to the basics of the related lecture in physical chemistry); sample preparation, acquisition techniques, law of Lambert and Beer, interpretation of IR spectra; Raman spectroscopy. UV/VIS spectroscopy: Basics, interpretation of electron spectra. Circular dichroism (CD) und optical rotation dispersion (ORD). Atomic absorption, emission, and X-ray fluorescence spectroscopy: Basics, sample preparation. | ||||
| Lecture notes | Script will be provided for factory costs. | ||||
| Literature | - R. Kellner, J.-M. Mermet, M. Otto, H. M. Widmer (Eds.) Analytical Chemistry, Wiley-VCH, Weinheim, 1998; - D. A. Skoog und J. J. Leary, Instrumentelle Analytik, Springer, Heidelberg, 1996; - M. Hesse, H. Meier, B. Zeeh, Spektroskopische Methoden in der organischen Chemie, 5. überarbeitete Auflage, Thieme, Stuttgart, 1995 - E. Pretsch, P. Bühlmann, C. Affolter, M. Badertscher, Spektroskopische Daten zur Strukturaufklärung organischer verbindungen, 4. Auflage, Springer, Berlin/Heidelberg, 2001- Kläntschi N., Lienemann P., Richner P., Vonmont H: Elementanalytik. Instrumenteller Nachweis und Bestimmung von Elementen und deren Verbindungen. Spektrum Analytik, 1996, Hardcover, 339 S., ISBN 3-86025-134-1. | ||||
| Prerequisites / Notice | Excercises are integrated in the lectures. In addition, attendance in the lecture 529-0289-00 "Instrumental analysis of organic compounts" (4th semester) is recommended. | ||||
| 529-0054-00L | Physical and Analytical Chemistry | 10 credits | 15P | E. C. Meister, R. Zenobi, M. Badertscher, M.‑O. Ebert, K. Eyer, B. Hattendorf, Y. Yamakoshi | |
| Abstract | Practical introduction to important experimental methods in physical and analytical chemistry. | ||||
| Learning objective | The students have to carry out selected experiments in physical chemistry and evaluate measurement data. They acquire a good knowledge about the most important practical techniques in analytical chemistry. Laboratory reports have to be written to each experiment. | ||||
| Content | Physical chemistry part: Short recapitulation of statistics and analysis of measurement data. Writing experimental reports with regard to publication of scientific works. Basic physical chemistry experiments (a maximum of six experiments from the following themes): 1. Phase diagrams (liquid-vapour and solid-liquid phase diagrams, cryoscopy); 2. electrochemistry and electronics; 3. quantum chemistry studies; 4. kinetics; 5. thermochemistry; 6. speed of sound in gases and liquids; 7. surface tension. Analytical chemistry part: 1. Introduction to the concept of sampling, quantitative elemental analysis and trace analysis, atomic spectroscopic methods, comparative measurements with electrochemical methods; 2. Separation methods, their principles and optimisation: comparison of the different chromatographic methods, effect of the stationary and mobile phases, common errors/artefacts, liquid chromatography, gas chromatography (injection methods). 3. Spectroscopic methods in organic structure determination: recording of IR and UV/VIS spectra, recording technique in NMR Mandatory exercises in spectroscopy in an accompanying tutorial 529-0289-00 "Instrumentalanalyse organischer Verbindungen" are an integral part of this course. | ||||
| Lecture notes | Descriptions for experiments available online. | ||||
| Literature | Für PC-Teil: Erich Meister, Grundpraktikum Physikalische Cheme, 2. Aufl. Vdf UTB, Zürich 2012. | ||||
| Prerequisites / Notice | Prerequisites: 529-0051-00 "Analytische Chemie I (3. Semester)" 529-0058-00 "Analytische Chemie II (4. Semester)" in parallel to the lab class, or completed in an earlier semester. The course 529-0289-00L "Instumentalanalyse organischer Verbindungen" is an obligatory component of the lab class / praktikum. | ||||
| 529-0058-AAL | Analytical Chemistry II Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. This course does not offer a lecture of its own but it is linked to the course 529-0058-00L. | 3 credits | 6R | D. Günther, M.‑O. Ebert, P. Lienemann, G. Schwarz, R. Zenobi | |
| Abstract | Enhanced knowledge about the elemental analysis and spectrocopical techniques with close relation to practical applications. This course is based on the knowledge from analytical chemistry I. Separation methods are included. | ||||
| Learning objective | Use and applications of the elemental analysis and spectroscopical knowledge to solve relevant analytical problems. | ||||
| Content | Combined application of spectroscopic methods for structure determination, and practical application of element analysis. More complex NMR methods: recording techniques, application of exchange phenomena, double resonance, spin-lattice relaxation, nuclear Overhauser effect, applications of experimental 2d and multipulse NMR spectroscopy, shift reagents. Application of chromatographic and electrophoretic separation methods: basics, working technique, quality assessment of a separation method, van-Deemter equation, gas chromatography, liquid chromatography (HPLC, ion chromatography, gel permeation, packing materials, gradient elution, retention index), electrophoresis, electroosmotic flow, zone electrophoresis, capillary electrophoresis, isoelectrical focussing, electrochromatography, 2d gel electrophoresis, SDS-PAGE, field flow fractionation, enhanced knowledge in atomic absorption spectroscopy, atomic emission spectroscopy, X-ray fluorescence spectroscopy, ICP-OES, ICP-MS. | ||||
| Literature | general: R. Kellner, J.-M. Mermet, M. Otto, H. M. Widmer (Eds.) Analytical Chemistry, Wiley-VCH, Weinheim, 1998; XRF: R. Schramm, X-Ray Fluorescence Analysis: Practical and Easy, Fluxana, Kleve, 2012; ICP-MS: R. Thomas, Practical Guide to ICP-MS - A Tutorial for beginners, 3rd Edition, CRC Press, Taylor & Francis Group, Boca Raton, 2013 (especially: chapters 1-15, 19 and 21). Separation methods: S. Ahuja (Ed.), Chromatography and Separation Science, Volume 4 of series "Separation Science and Technology", Elsevier Academic Press, San Diego, 2003. K. Robards, P. R. Haddad, and P. E. Jackson, Principle and Practise of Modern Chromatographic Methods, Academic Press, London, 1994. F. Foret, L. Krivankova, and P. Bocek, Capillary Zone Electrophoresis, VCH, Weinheim (1993) | ||||
| Prerequisites / Notice | None. | ||||
| 529-0280-00L | Analytical Chemistry Seminar | 0 credits | 1K | R. Zenobi | |
| Abstract | Analytical Chemistry Seminar | ||||
| Learning objective | Presentation and discussion of current research topics in analytical chemistry | ||||
| Content | Presentation and discussion of current research topics in analytical chemistry | ||||
| 529-0289-00L | Spectra Interpretation of Organic Compounds | 2 credits | 2G | R. Zenobi, M. Badertscher, K. Eyer, Y. Yamakoshi | |
| Abstract | Exercises in interpretation of molecular spectra | ||||
| Learning objective | Mastering the interpretation of molecular spectra. | ||||
| Content | In the first part of the lecture, the students work in small groups on solving particular problems in structure elucidation, interpreting mass, 1H-NMR, 13C-NMR, IR, and UV/VIS spectra, optionally in discussion with the lecturers. In the second part the problems are solved by a lecturer. | ||||
| Lecture notes | Spectroscopic problems will be distributed | ||||
| Literature | E. Pretsch, P. Bühlmann, M. Badertscher, Structure Determination of Organic Compounds: Tables of Spectral Data, Springer-Verlag, Berlin, 2009, 4th revised and enlarged Engl. ed. E. Pretsch, G. Tóth, M. E. Munk, M. Badertscher, Computer-Aided Structure Elucidation: Spectra Interpretation and Structure Generation, Wiley-VCH, Weinheim, 2002. | ||||
| Prerequisites / Notice | The course is based on the lectures Analytical Chemistry I (529-0051-00) and Analytical Chemistry II (529-0058-00). Solutions to the problems will be posted on the internet. | ||||
| 529-0290-00L | Organic Chemistry (Seminar)  | 0 credits | 2S | J. W. Bode, E. M. Carreira, D. Hilvert, H. Wennemers, R. Zenobi | |
| Abstract | Seminars on Current Topics in Organic Chemistry, Chemical Biology, and Analytical Chemistry. | ||||
| Learning objective | Awareness of contemporary trends in science. | ||||
| 529-0299-00L | Organic Chemistry | 0 credits | 1.5K | J. W. Bode, E. M. Carreira, P. Chen, D. Hilvert, H. Wennemers, R. Zenobi | |
| Abstract | Updates on Research and Contemporary Literature in Organic Chemistry and Chemical Biology. | ||||
| Learning objective | Problem solving in organic chemistry and chemical biology. | ||||