Markus Aebi: Catalogue data in Autumn Semester 2018

Award: The Golden Owl
Name Prof. em. Dr. Markus Aebi
Institut für Mikrobiologie
ETH Zürich, HCI F 439
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
Telephone+41 44 632 64 13
RelationshipProfessor emeritus

551-0105-00LFundamentals of Biology IA5 credits5GM. Aebi, E. Hafen, M. Peter
AbstractThe course provides an introduction to the basics of molecular- and cell biology and genetics.
ObjectiveIntroduction to modern biology and to principal biological concepts.
ContentThe course is divided into several chapters:
1. Basic principles of Evolution.
2. Chemistry of Life: Water; Carbon and molecular diversity; biomolecules
3. The cell: structure; membrane structure and function, cell cycle
4. Metabolism: Respiration; Photosynthesis; Fermentation
5. Inheritance: meiosis and sexual reproduction; Mendelian genetics, chromosomal basis of inheritance, molecular basis of inheritance, from gene to protein, regulation of gene expression; genomes and their evolution
Lecture notesNone.
LiteratureThe text-book "Biology" (Campbell, Reece) (10th edition) is the basis of the course.
The structure of the course is largely identical with that of the text-book.
Prerequisites / NoticeCertain sections of the text-book must be studied by self-instruction.
551-0363-00LComplex Carbohydrates - Biosynthesis, Structure & Function Information Restricted registration - show details
Number of participants limited to minimum 2 and maximum 8.

The enrolment is done by the D-BIOL study administration.
6 credits7GM. Aebi, T. Keys
AbstractIn vitro & in vivo experiments will introduce current research on the biosynthesis, structure & function of protein-bound glycans in different pro- and eukaryotic microorganisms.
ObjectiveParticipants are familiar with the biosynthesis, structure and function of N-glycans in microorganisms and with the methods for their analysis.
Content* Topics: biosynthesis of asparagine-linked glycans in pro- and eukaryotes; structure of glycans in different organisms; methods to analyse the structure of glcans; function of glycans in protein quality control
* Introductory lectures
* Seminar with presentation and discussion of recent publications
* Experiments that exemplify the current research done in the group
551-1105-00LGlycobiology4 credits2VM. Aebi, T. Hennet
AbstractStructural principles, nomenclature and different classes of glycosylation. The different pathways of N- and O-linked protein glycosylation and glycolipid biosynthesis in prokaryotes and eukaryotes are discussed. Specific glycan binding proteins and their role in deciphering the glycan code are presented. The role of glycans in infectious diseases, antigen mimicry and autoimmunity are discussed.
ObjectiveDetailed knowledge in 1) the different areas of prokaryotic and eukaryotic glycobiology, in particular in the biosynthesis of glycoproteins and glycolipids, 2) the cellular machinery required for these pathways, 3) the principles of carbohydrate/protein interaction, 4) the function of lectins, 5) the role of glycans in infectious disease.
ContentStructure and linkages; analytical approaches; N-linked protein glycosylation (ER, Golgi); glycan-assisted protein folding and quality control; O-linked protein glycosylation; glucosaminoglycans; glycolipids; prokaryotic glycosylation pathways; lectins; glycans and infectious disease
Lecture noteshandouts
LiteratureIntroduction to Glycobiology; M.E.Taylor, K.Drickamer, Oxford University Press, 2003
Essentials of Glycobiology (third edition); A.Varki et al. Cold Spring Harbor Laboratory Press, 2017
Prerequisites / NoticeThe course will be in English. It will include the preparation of short essays (marked) about defined topics in Glycobiology.
551-1106-00LProgress Reports in Microbiology and Immunology
Students must sign up via
0 credits5SJ. Piel, M. Aebi, H.‑M. Fischer, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli
AbstractPresentation and discussion of current research results in the field of Microbiology and Infection Immunology
ObjectivePrecise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims
551-1109-00LSeminars in Microbiology0 credits2KM. Aebi, H.‑M. Fischer, W.‑D. Hardt, M. Künzler, J. Piel, S. Sunagawa, J. Vorholt-Zambelli
AbstractSeminars by invited speakers covering selected microbiology themes.
ObjectiveDiscussion of selected microbiology themes presented by invited speakers.