Markus Aebi: Catalogue data in Autumn Semester 2017 |  |
| Name | Prof. em. Dr. Markus Aebi |
| Field | Mykologie |
| Address | Institut für Mikrobiologie ETH Zürich, HCI F 439 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| markus.aebi@micro.biol.ethz.ch | |
| Department | Biology |
| Relationship | Professor emeritus |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 551-0105-00L | Fundamentals of Biology IA | 5 credits | 5G | M. Aebi, E. Hafen, M. Peter | |
| Abstract | The course provides an introduction to the basics of molecular- and cell biology and genetics. | ||||
| Learning objective | Introduction to modern biology and to principal biological concepts. | ||||
| Content | The course is divided into several chapters: 1. Basic principles of Evolution. 2. Chemistry of Life: Water; Carbon and molecular diversity; biomolecules 3. The cell: structure; membrane structure and function, cell cycle 4. Metabolism: Respiration; Photosynthesis; Fermentation 5. Inheritance: meiosis and sexual reproduction; Mendelian genetics, chromosomal basis of inheritance, molecular basis of inheritance, from gene to protein, regulation of gene expression; genomes and their evolution | ||||
| Lecture notes | None. | ||||
| Literature | The text-book "Biology" (Campbell, Reece) (10th edition) is the basis of the course. The structure of the course is largely identical with that of the text-book. | ||||
| Prerequisites / Notice | Certain sections of the text-book must be studied by self-instruction. | ||||
| 551-0363-00L | Complex Carbohydrates - Biosynthesis, Structure & Function   Number of participants limited to minimum 2 and maximum 8. The enrolment is done by the D-BIOL study administration. | 6 credits | 7G | M. Aebi, T. Keys | |
| Abstract | In vitro & in vivo experiments will introduce current research on the biosynthesis, structure & function of protein-bound glycans in different pro- and eukaryotic microorganisms. | ||||
| Learning objective | Participants are familiar with the biosynthesis, structure and function of N-glycans in microorganisms and with the methods for their analysis. | ||||
| Content | * Topics: biosynthesis of asparagine-linked glycans in pro- and eukaryotes; structure of glycans in different organisms; methods to analyse the structure of glcans; function of glycans in protein quality control * Introductory lectures * Seminar with presentation and discussion of recent publications * Experiments that exemplify the current research done in the group | ||||
| 551-1105-00L | Glycobiology | 4 credits | 2V | M. Aebi, T. Hennet | |
| Abstract | Structural principles, nomenclature and different classes of glycosylation. The different pathways of N- and O-linked protein glycosylation and glycolipid biosynthesis in prokaryotes and eukaryotes are discussed. Specific glycan binding proteins and their role in deciphering the glycan code are presented. The role of glycans in infectious diseases, antigen mimicry and autoimmunity are discussed. | ||||
| Learning objective | Detailed knowledge in 1) the different areas of prokaryotic and eukaryotic glycobiology, in particular in the biosynthesis of glycoproteins and glycolipids, 2) the cellular machinery required for these pathways, 3) the principles of carbohydrate/protein interaction, 4) the function of lectins, 5) the role of glycans in infectious disease. | ||||
| Content | Structure and linkages; analytical approaches; N-linked protein glycosylation (ER, Golgi); glycan-assisted protein folding and quality control; O-linked protein glycosylation; glucosaminoglycans; glycolipids; prokaryotic glycosylation pathways; lectins; glycans and infectious disease | ||||
| Lecture notes | handouts | ||||
| Literature | Introduction to Glycobiology; M.E.Taylor, K.Drickamer, Oxford University Press, 2003 Essentials of Glycobiology (second edition); A.Varki et al. Cold Spring Harbor Laboratory Press, 2009 | ||||
| Prerequisites / Notice | The course will be in English. It will include the preparation of short essays (marked) about defined topics in Glycobiology. | ||||
| 551-1106-00L | Progress Reports in Microbiology and Immunology Students must sign up via secr.micro.biol.ethz.ch | 0 credits | 5S | J. Piel, M. Aebi, H.‑M. Fischer, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli | |
| Abstract | Presentation and discussion of current research results in the field of Microbiology and Infection Immunology | ||||
| Learning objective | Precise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims | ||||
| 551-1109-00L | Seminars in Microbiology | 0 credits | 2K | M. Aebi, H.‑M. Fischer, W.‑D. Hardt, M. Künzler, J. Piel, S. Sunagawa, J. Vorholt-Zambelli | |
| Abstract | Seminars by invited speakers covering selected microbiology themes. | ||||
| Learning objective | Discussion of selected microbiology themes presented by invited speakers. | ||||