Bruno Alfred Gander: Catalogue data in Spring Semester 2019

Name	Prof. em. Dr. Bruno Alfred Gander
Field	Pharmazeutische Technologie und Applikationssysteme
E-mail	bruno.gander@retired.ethz.ch
Department	Chemistry and Applied Biosciences
Relationship	Retired Adjunct Professor

Number	Title	ECTS	Hours	Lecturers
535-0419-00L	Laboratory Course in Galenical Pharmacy	5 credits	9P	J.‑C. Leroux, B. A. Gander
Abstract	The students gain knowledge on excipients, the preparation of simple dosage forms under consideration of basic quality assurance requirements, on quality control of medicaments and pharmacopoeial requirements. This enables them to analyse and understand simple galenical problems, to study them experimentally, and to evaluate and present the data in a scientific format.
Learning objective	„Introductory stations“: The students dispose of knowledge on pharmaceutical excipients, preparation methods for simple important dosage forms, and related quality assurance and quality control aspects. With this knowledge, the students are able to prepare simple dosage forms under basic quality assurance measures and to control the galenical quality of the medicaments. The students also possess knowledge on relevant pharmacopoeial requirements and on contents of formularies and excipients handbooks. „Mini project“: The students are able to comprehend and analyse basic galenical problems in their context. The students are also able to use data and information from the literature and other resources to develop a relevant experimental plan for solving experimentally basic galenical problems under consideration of quality assurance issues. The students are finally able to present and evaluate the experiments and data in a scientifically sound oral presentation and written report (publication style).
Content	„Introductory stations“: Knowledge, comprehension and application of methods and techniques in the following areas: drug dissolution testing; disintegration of dosage forms; grinding and mixing of powders; granulation; extrusion; pelletization; flowability of powders; true and apparent densities of powders, sieve analyses; specific surfaces of powders; compression and in-process controls; quality control charts and quality control of tablets; working with inflammable solvents in coating processes; fluidized bed and drum coating processes; dispersion and homogenisation of liquid and semi-solid dosage forms; preparation of gels and ointments by means of the IKA-reactor and Stefan-mixer; preparation of liquid emulsions and suspensions by means of high-shear homogenizer; rheological measurements of viscous systems; particle size measurements by means of laser light diffractometry; zeta potential measurements; microscopy and microphotography; surfaced tension of liquid (tensiometry); water purification; sterilisation; sterility testing; freeze-drying; osmometry; conductometry; liposomes. „Mini project“ (selected topics): e.g., hydrocortison-loaded liposomes; stability of lysozyme; thermogels; swinging gels; preparation of hand crèmes; study of complex emulsifiers; diazepam tablets with modified drug release; acetylsalicylic acid tablets with sustained release.
Lecture notes	Printed script on selected methods; manuals and other documents.
Literature	Eur. Pharm. (European Pharmacopoeia) USP (United States Pharmacopeia) K.H. Bauer, K.-H. Frömming, C. Führer Lehrbuch der pharmazeutisK.H. Bauer, K.-H. Frömming, C. Führer, Lehrbuch der pharmazeutischen Technologie. 8. Auflage, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2006 C.D. Herzfeldt, J. Kreuter, Grundlagen der Arzneiformenlehre. Springer, Berlin, 1999 C.D. Herzfeldt, Propädeutikum der Arzneiformenlehre. 2. Auflage, Springer, Berlin, 2000
Prerequisites / Notice	Teaching methods: Demonstrations; Practical guided exercises; Self-guided literature research; Questionnaires; Seminars; Self-guided experimental project work. Requirements: Laboratory course in Pharmaceutical Analytics passed Lecture in Galenical Pharmacy I Lecture in Galenical Pharmacy II in the same semester or previously
535-0421-AAL	Galenical Pharmacy I+II Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.	4 credits	7R	J.‑C. Leroux, B. A. Gander
Abstract	Principles and technologies for the manufacturing of dosage forms and drug delivery systems. Knowledge of pharmaceutical excipients, materials, containers, liquid, solid and semi-solid dosage forms, their production, function, quality and application.
Learning objective	Knowledge of the most important pharmaceutical excipients, materials, containers, liquid, solid and semi-solid dosage forms, of their production, function, quality, stability and application. Comprehension of the molecular interactions in solid state, solution and colloidal systems.
Content	Introduction and overview of important fundamentals, principles and technologies for the development and manufacturing of dosage forms and drug delivery systems. Overview of the most important pharmaceutical excipients and polymers, their structure, properties and processing; importance of materials properties for containers. Pharmaceutical solvents, fundamentals of solubility and solubilization of drugs. Water treatment processes, sterilization techniques and quality requirements of pharmaceutical water. Parenteral dosage forms and liquid ophthalmics. Surfactants, micelle formation and colloidal systems. Liquid suspensions and emulsions. Stabilization measures in dosage forms. Important fundamentals, principles and technologies for the development and manufacturing of solid dosage forms and drug delivery systems. Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration.
Literature	M. E. Aulton and K. M. G. Taylor, Aulton's Pharmaceutics: The design and manufacture of medicines, 5th ed, Churchill Livingston, Philadelphia, 2017. (excepting chapters 25, 42 and 45)
535-0422-00L	Galenical Pharmacy II	2 credits	2G	J.‑C. Leroux, B. A. Gander
Abstract	Continues Galenical Pharmacy I. Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Suppositories. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration.
Learning objective	Introduction and overview of important fundamentals, principles and technologies for the development and manufacturing of dosage forms and drug delivery systems. In continuation of Galenical Pharmacy I. The students dispose of knowledge of properties, function, quality and application of dosage forms. The following topics will be covered: Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Suppositories. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration. Formulation of biotechnology products.
Content	Overview of important fundamentals, principles and technologies for the development and manufacturing of solid dosage forms and drug delivery systems. Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration.
Lecture notes	Scripts, documentations to the lectures and additional supporting materials can be either downloaded via the indicated link to the course , or they will be directly provided at each lecture.
Literature	A.T. Florence - An introduction to clinical pharmaceutics. Pharmaceutical Press, London 2010. L.V. Allen, N.G. Popovich, H.C. Ansel, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, 10th Ed, Lippincott Williams & Wilkins, Baltimore 2014. L. Felton, Remington - Essentials of Pharmaceutics, Pharmaceutical Press, London, 2013. M.E. Aulton. Pharmaceutics - The design and manufacture of medicines. 5th Ed. Elsevier, Philadelphia, 2017. Sinko P.J., Martin's Physical Pharmacy and Pharmaceutical Sciences, 7th ed, Wolters Kluwer, Philadelphia, 2017.
Prerequisites / Notice	Prior attendance of Galenical Pharmacy I is recommended.