Ulrich Suter: Catalogue data in Spring Semester 2020
|Name||Prof. Dr. Ulrich Suter|
Inst. f. Molecular Health Sciences
ETH Zürich, HPL F 36
|Telephone||+41 44 633 34 32|
|551-0103-AAL||Fundamentals of Biology II: Cell Biology|
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.
Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
|5 credits||11R||U. Kutay, Y. Barral, E. Hafen, G. Schertler, U. Suter, S. Werner|
|Abstract||The goal of this course is to provide students with a wide general understanding in cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.|
|Objective||The goal of this course is to provide students with a wide general understanding cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.|
|Content||The focus is animal cells and the development of multicellular organisms with a clear emphasis on the molecular basis of cellular structures and phenomena. The topics include biological membranes, the cytoskeleton, protein sorting, energy metabolism, cell cycle and division, viruses, extracellular matrix, cell signaling, embryonic development and cancer research.|
|Literature||Alberts et al. 'Molecular Biology of the Cell' 6th edition, 2014, ISBN 9780815344322 (hard cover) and ISBN 9780815345244 (paperback).|
Analyzing cells & molecules / Gebhard Schertler/8/ 439-463;
Membrane structure / Gebhard Schertler/ 10/ 565-595;
Compartments and Sorting/ Ulrike Kutay/12+14+6/641-694/755-758/782-783/315-320/325 -333/Table 6-2/Figure6-20, 6-21, 6-32, 6-34;
Intracellular Membrane Traffic/ Ulrike Kutay/13/695-752;
The Cytoskeleton/ Ulrike Kutay/ 16/889 - 948 (only the essentials);
Membrane Transport of Small Molecules and the Electrical Properties of Membranes /Sabine Werner/11/597 - 633;
Mechanisms of Cell Communication / Sabine Werner/15/813-876;
Cancer/ Sabine Werner/20/1091-1141;
Cell Junctions and Extracellular Matrix/Ueli Suter / 1035-1081;
Stem Cells and Tissue Renewal/Ueli Suter /1217-1262;
Development of Multicellular organisms/ Ernst Hafen/ 21/ 1145-1179 /1184-1198/1198-1213;
Cell Migration/Joao Matos/951-960;
Cell Death/Joao Matos/1021-1032;
Cell Cycle/chromosome segregation/Cell division/Meiosis/Joao Matos/ 963-1018.
|Prerequisites / Notice||none|
|551-0104-00L||Fundamentals of Biology II |
Registrations via myStudies until 29.1.2020 at the latest. Subsequent registrations will not be considered.
|8 credits||8P||M. Gstaiger, E. Dultz, C. H. Giese, W. Kovacs, D. Santelia, H. Stocker, U. Suter, S. Werner|
|Abstract||This introductory Laboratory course introduces the student to the entire range of classical and modern molecular biosciences. In the second year (Praktikum GL Bio II) the students will perform three praktikum days in:|
- Molecular Biology
- Plant Physiology
- Genetics and
- Cell Biology II.
(total of 12 experiments)
Each experiment takes one full day.
|Objective||Introduction to theoretical and experimental biology|
Moodle www-link for general Praktikum-information and course material: Moodle
The general Praktikum information (Assignment list, Instructions and Schedule & Performance Sheet) will also be sent to the students directly (E-mail).
|Content||The class is divided into four blocks: Cell Biology II, Genetics, Molecular Biology and Plant Physiology. One block lasts three weeks.|
CELL BIOLOGY II:
- Cells: Cell types & staining methods, cell fusion & cell motility,
- Tissue and development: histology of mice embryos & embryogenesis
- Repair mechanisms: DNA repair & wound healing,
- Yeast genetics
- Drosophila genetics
- Human genetics
- Molecular biology & protein crystallization
- Enzyme kinetics
- Redox potential & stability of a protein
- Plants and light
- Phytohormones and other growth factors
- Molecular biology of systemic gene silencing
- Literature and presentations
The students will also prepare short presentations (approx. 10 min) of the various topics within this course.
|Lecture notes||Laboratory manuals|
CELL BIOLOGY II
- The protocols can be downloaded from: Moodle
- The protocols can be found from: Moodle
- The protocols can be found from: Moodle
- The protocols can be found from: Moodle
|Prerequisites / Notice||THE PRAKTIKUM RULES:|
Your attendance is obligatory and you have to attend all 12 Praktikum days. Absences are only acceptable if you are able to provide a Doctor’s certificate. The original Dr's certificate has to be given to Dr. M. Gstaiger (HPM F43) within five days of the absence of the Praktikum day.
If there will be any exceptional or important situations then you should directly contact the Director of Studies of D-Biol, who will decide if you are allowed to miss a Praktikum day or not.
1. Due to the increased number of students, the official Praktikum registration has to be done, using myStudies, preferably at the end of HS18 but not later than Wednesday January 30, 2020.
2. Later registration is NOT possible and can NOT be accepted!
3. The course registration for FS20 is usually possible at the end of HS18 and you will obtain an E-mail from the Rectorate when the course registration using myStudies is possible.
Students can register for a practice group via myStudies. As soon as the course unit is registered in myStudies, a text box appears indicating that a group can be selected. Accordingly, students can select a group in the next step. If more than 180 students register, the surplus students will be placed on a waiting list and then allocated by the course responsible.
The Praktikum GL BioII FS20 will take place during the following days and therefore, you have to make sure already now that you do not have any other activities & commitments during these days:
PRAKTIKUM DAYS DURING FS19 (Fridays):
21.2. / 28.2. / 6.3. / 13.3. / 20.3. / 27.3. / 3.4. / 24.4. / 8.5. / 15.5. / 22.5. / 29.5
No Praktikum during the Easter break: 9.4.-17.4. 2020
|551-0326-00L||Cell Biology||6 credits||4V||S. Werner, M. Bordoli, W. Kovacs, M. Schäfer, U. Suter, A. Wutz|
|Abstract||This Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.|
|Objective||-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.|
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
|551-0512-00L||Current Topics in Molecular and Cellular Neurobiology |
Does not take place this semester.
Number of participants limited to 8
|2 credits||1S||U. Suter|
|Abstract||The course is a literature seminar or "journal club". Each Friday a student, or a member of the Suter Lab in the Institute of Molecular Health Sciences, will present a paper from the recent literature.|
|Objective||The course introduces you to recent developments in the fields of cellular and molecular neurobiology. It also supports you to develop your skills in critically reading the scientific literature. You should be able to grasp what the authors wanted to learn e.g. their goals, why the authors chose the experimental approach they used, the strengths and weaknesses of the experiments and the data presented, and how the work fits into the wider literature in the field. You will present one paper yourself, which provides you with practice in public speaking.|
|Content||You will present one paper yourself. Give an introduction to the field of the paper, then show and comment on the main results (all the papers we present are available online, so you can show original figures with a beamer). Finish with a summary of the main points and a discussion of their significance.|
You are expected to take part in the discussion and to ask questions. To prepare for this you should read all the papers beforehand (they will be announced a week in advance of the presentation).
|Lecture notes||Presentations will be made available after the seminars.|
|Literature||We cover a range of themes related to development and neurobiology. Before starting your preparations, you are required to check with Laura Montani (firstname.lastname@example.org), who helps you with finding an appropriate paper.|
|Prerequisites / Notice||You must attend at least 80% of the journal clubs, and give a presentation of your own. At the end of the semester there will be a 30 minute oral exam on the material presented during the semester. The grade will be based on the exam (45%), your presentation (45%), and a contribution based on your active participation in discussion of other presentations (10%).|
|551-1516-00L||Neuron-Glia Interactions and Myelination in Health and Disease |
Number of participants limited to 15.
The enrolment is done by the D-BIOL study administration.
|6 credits||7G||U. Suter|
|Abstract||The course provides general basic insights and new perspectives in the development, plasticity and repair of the nervous system. The focus is on molecular, cellular and transgenic approaches.|
|Objective||Through a combination of practical work with lectures, discussions, project preparations and presentations, the students learns basic principles of neural plasticity and repair in health and disease. The course is closely linked to ongoing research projects in the lab to provide the participants with direct insights into current experimental approaches and strategies.|