Kurt Wüthrich: Catalogue data in Spring Semester 2015 |
| Name | Prof. Dr. Kurt Wüthrich |
| Field | Biophysik |
| Address | Inst. f. Molekularbiol.u.Biophysik ETH Zürich, HPK G 17 Otto-Stern-Weg 5 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 24 73 |
| Fax | +41 44 633 11 51 |
| kw@mol.biol.ethz.ch | |
| Department | Biology |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 551-0142-00L | Structure Determination of Biological Macromolecules by X-ray Crystallography and NMR | 6 credits | 3G | F. Allain, N. Ban, K. Locher, G. Wider, K. Wüthrich, further lecturers | |
| Abstract | The course provides an overview of experimental methods for the determination of structures of macromolecules at atomic resolution. | ||||
| Learning objective | Insight into the methodology, areas of application and limitations of two principal methods for the structure determination of biological macromolecules. | ||||
| Content | Part I: Methods for the determination of the structure of proteins and macromolecular complexes using X-ray diffraction in single crystals. Part II: Methods for the determination of protein structures in solution using nuclear magnetic resonance (NMR) spectroscopy. Experimental approaches to the characterization of intramolecular dynamics of proteins. | ||||
| Literature | 1) Wüthrich, K. NMR of Proteins and Nucleic Acids, Wiley-Interscience. 2) Blow, D. Outline of Crystallography for Biologists. Oxford University Press. | ||||
| 551-0434-00L | NMR Spectroscopy in Biology  Number of participants limited to 10 | 6 credits | 7G | F. Allain, G. Wider, K. Wüthrich | |
| Abstract | In this block course, students actively participate in ongoing research projects in the research groups of Profs. Allain, Wider and Wüthrich. The students will be tutored in their experimental work by doctoral or postdoctoral students. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as excercises and literature work. | ||||
| Learning objective | The course provides first "hands on" insight into applications of NMR spectroscopy in biological sciences. The course should enable the students to understand the potential and limitations of NMR applied to biological problems. | ||||
| Content | The topics include studies of proteins, RNA and protein-RNA interactions, Participation in one of the following projects will be possible: - NMR of RNA - NMR of several protein-RNA complexes (hnRNPF, nPTB, SR proteins) - NMR studies of glycoproteins - dynamics of protein-RNA complexes - Segmental isotopic labeling to study multidomain proteins -Structural and dynamic properties of FtsZ, the bacterial homolog of tubulin - investigations of the ubiquitinom - NMR Methods Development | ||||
| Lecture notes | No script | ||||
| Literature | Lists of individual reading assignments will be handed out. | ||||
| 551-1620-00L | Molecular Biology, Biophysics | 1 credit | 1K | R. Glockshuber, F. Allain, N. Ban, K. Locher, E. Weber-Ban, G. Wider, K. Wüthrich | |
| Abstract | The course consists of a series of research seminars on Structural Biology and Biophysics, given by both scientists of the National Center of Competence in Research (NCCR) in Structural Biology and external speakers. | ||||
| Learning objective | The goal of this course is to provide doctoral and postdoctoral students with a broad overview on the most recent developments in biochemistry, structural biology and biophysics. | ||||
| Prerequisites / Notice | Information on the individual seminars is provided on the following websites: http://www.structuralbiology.unizh.ch/events005.asp http://www.biol.ethz.ch/dbiol-cal/index | ||||