Suchergebnis: Katalogdaten im Herbstsemester 2017

Nummer	Titel	Typ	ECTS	Umfang	Dozierende
Biologie Bachelor
3. Studienjahr, 5. Semester
Blockkurse Anmeldung zu Blockkursen muss zwingend über die website https://www.uzh.ch/zoolmed/ssl-dir/Blockkurse_UNIETH.php erfolgen. Anmeldung möglich von 24.7.2017 bis 6.8.2017.
Blockkurse im 1. Semesterviertel Von 19.9.2017 13:00 Uhr bis 11.10.2017 17:00 Uhr
551-0333-00L	Biodiversität und ökologische Bedeutung der Pilze Maximale Teilnehmerzahl: 8 Die Belegung erfolgt nur über das Studiensekretariat D-BIOL.	W	6 KP	7P	A. Leuchtmann, R. Berndt, B. Senn-Irlet
Kurzbeschreibung	Einführung in die Biologie, Systematik und Ökologie der wichtigsten Pilzgruppen. Die Kursteilnehmer(innen) untersuchen vor allem Material, das auf Exkursionen selbst gesammelt oder im Labor isoliert wurde.
Lernziel	Kennenlernen der Hauptgruppen pilzartiger Organismen, ihrer Merkmale, Lebensweise und ökologischen Bedeutung. Erlernen von Methoden, mit denen Pilze gesammelt, mikroskopisch untersucht und identifiziert werden können.
Inhalt	Die Studierenden lernen die Merkmale und Besonderheiten der Pilze und pilzartigen Organismen kennen und erhalten einen Überblick über die Systematik der Ascomycota und Basidiomycota, und eventuell weiterer ausgewählter Gruppen. Die Ökologie der Pilze wird anhand von ausgewählten Pilzgemeinschaften (z.B. Holz- und Streueabbauer, Dungbewohner, Endophyten) vorgestellt. Im Rahmen eines kleinen Projekts befassen sich die Teilnehmer/innen mit pflanzenparasitischen Pilzen (vor allem Rost- und Mehltaupilzen) und lernen, wie man diese Pilze findet, mikroskopiert und bestimmt. Auf mehreren Exkursionenen werden wir die Vielfalt und Ökologie der Pilze am natürlichen Standort studieren. Die Exkursionen dienen auch dem Sammeln von Material, an dem wir im Kurs die Mikroskopie und Präparation der Pilze üben werden.
Skript	Übersichten und Skriptunterlagen zum Kursstoff werden abgegeben.
Literatur	Webster, J., and Weber, R. W. S. 2007. Introduction to Fungi. Cambridge University Press, Oxford, 3rd edition, 841 S. Alexopoulos, C. J., Mims, C. W., and Blackwell, M. 1996. Introductory Mycology. John Wiley & Sons, 4th ed., 868 S. Dix, N. J., Webster, J. 1995. Fungal Ecology. Chapman & Hall, London, 549 S.
551-0347-00L	Molecular Mechanisms of Cell Growth and Polarity Number of participants limited to 12. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	R. Kroschewski, Y. Barral, S. Jessberger, M. Peter
Kurzbeschreibung	Introduction to the principles and molecular mechanisms of cell polarity, using animal cells and fungi as model systems.
Lernziel	The students learn to describe the principles and molecular mechanisms of cell polarity, using different model systems as examples: - Animal cells during epithelial and neuronal differentiation - Fungi during morphogenesis and aging. Based on lectures, literature reading, discussions, presentations and practical lab work the students will be able to compare experimental strategies in different model systems, and to develop open questions in the field of cell polarity. Students will also know about the mechanisms and consequences of asymmetric cell division such as those performed by stem cells and asymmetric protein functions during morphogenesis and aging.
Inhalt	During this Block-Course, the students will learn to (1) describe and compare the principles and molecular mechanisms of cell polarity in fungi and animal cells, (2) apply, evaluate and compare experimental strategies in the different model systems, and (3) select the best model system to answer a particular question. Students - in groups of 2 or max 3- will be integrated into a research project connected to the subject of the course, within one of the participating research groups. Lectures and technical notes will be given and informal discussions held to provide you with the theoretical background.
Skript	There will be optional papers to be read before the course start. They serve as framework orientation for the practical parts of this block course and will be made accessible to you shortly before the course starts on the relevant Moodle site.
Literatur	Documentation and recommended literature (review articles) will be provided during the course.
551-1129-00L	Understanding and Engineering Microbial Metabolism Number of participants limited to 6. The enrolment is done by the D-BIOL study administration.	W	6 KP	7P	J. Vorholt-Zambelli
Kurzbeschreibung	This laboratory course has a focus on current research topics in our laboratory related to metabolic engineering, the general understanding of metabolism, and is focused particularly on C1-metabolism. Projects will be conducted in small groups.
Lernziel	The course aims at introducing key principles of metabolic engineering and techniques applied in metabolism related research. The main focus of this block course is on practical work and will familiarize participants with complementary approaches, in particular genetic, biochemical and analytical techniques. Results will be presented by students in scientific presentations.
Inhalt	The course and will include topics such as pathway elucidation & engineering and related ongoing research projects in the lab. Experimental work applied during the course will comprise methods such as cloning work & transformation, growth determination, enzyme activity assays, liquid-chromatography mass-spectrometry and dynamic labeling experiments.
Skript	None
Literatur	Will be provided at the beginning of the course.
551-1711-00L	Translational Medicine and Bio-Entrepreneurship Number of participants limited to 30 The block course will only take place with a minimum of 10 participants. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	U. K. Genick, E. Hafen, M. Jenni
Kurzbeschreibung	The course gives students a look at the entire drug development process from bench to bedside. ETH and UZH alumni from the pharma, biotech, medtech, digital health and venture capital industry will discuss how intellectual property, regulatory and financial aspects shape this process. Student teams will develop their own business idea and pitch it to a group of entrepreneurs and investors.
Lernziel	Students know the basis of the drug development process, the basis of patenting and what is required to the start a life science company. The can develop a business idea and a rough financial plan and they can it to a panel of experts.
551-1119-00L	Microbial Community Genomics and Transcriptomics Number of participants limited to 5. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	S. Sunagawa
Kurzbeschreibung	Introduction to current research methods in the analysis of microbial communities using Next Generation Sequencing approaches - metagenomics and metatranscriptomics. Practical experience of work in a computational laboratory and an introduction to scientific programming.
Lernziel	Gain skills in data analysis and presentation for oral and written reports. Lectures introducing state-of-the-art in respective research areas and community microbiology, which is the target of ongoing research. Start to assess current literature.

Blockkurse im 2. Semesterviertel Von 12.10.2017 08:00 Uhr bis 3.11.2017 17:00 Uhr
Nummer	Titel	Typ	ECTS	Umfang	Dozierende
551-0345-00L	Mechanisms of Bacterial Pathogenesis Number of participants limited to 9. The enrolment is done by the D-BIOL study administration.	W	6 KP	7P	W.‑D. Hardt, M. Diard, B. Nguyen
Kurzbeschreibung	Forschungslaborpraktikum. In Kleingruppen werden Forschungsprojekte zu aktuellen Fragestellungen der Infektionsbiologie bearbeitet.
Lernziel	Einarbeitung in ein aktuelles Thema der zellulären Mikrobiologie bzw. der Molekularbiologie eines Infektionserregers. Experimentelles Arbeiten im Forschungslabor und Erlernen der infektionsbiologischen Arbeitsmethodik. Umgang mit der aktuellen Forschungsliteratur. Erstellung eines aussagekräftigen Versuchsprotokolls. Erfolgskontrolle: mündliche Präsentation der Forschungsresultate und Bewertung des Forschungsberichts.
Inhalt	Forschungsprojekte zum Modell-Pathogen Salmonella.
Skript	keines.
Literatur	Literatur wird jeweils aktuell zu jedem Projekt angegeben.
551-0421-00L	Biologie und Ökologie der Pilze im Wald Maximale Teilnehmerzahl: 10 Die Belegung erfolgt nur über das Studiensekretariat Biologie.	W	6 KP	7G	I. L. Brunner, S. H. Egli, D. H. Rigling
Kurzbeschreibung	Einführung in die biologischen und ökologischen Grundlagen der Pilze im Wald. Behandlung der Mykorrhizapilze, der saproben Pilze und der pathogenen Pilze und ihrer funktioneller Bedeutung im Wald. Vorstellung aktueller methodischer Forschungsansätze anhand ausgewählter Beispiele mit praktischen Arbeiten im Wald und im Labor, sowie mit Exkursionen und Vorlesungen.
Lernziel	Kenntnis der Pilze im Wald und ihrer ökologischen Bedeutung. Kennenlernen von aktuellen methodischen Foschungsansätzen. Selbständige und vertiefte Beschäftigung mit ausgewählten Aspekten der Pilze im Wald.
Inhalt	Einführung in die Pilze im Wald, Übersicht über die Systematik der Waldpilze, Bestimmung der Pilze und Herstellung von Reinkulturen aus Fruchtkörpern. Kennenlernen der verschiedenden Ernährungsweisen und Substratgruppen, Ansetzen der Pilzkulturen zu Versuchen zum Ligninabbau. Kenntnis der Giftpilze und Pilzgifte sowie weiterer Sekundärmetaboliten. Bedeutende pathogene Pilze von Waldbäumen. Feld- und Laborversuche zur Identifizierung und Quantifizierung von pathogenen Bodenpilzen am Beispiel des Hallimaschs. Vegetative Inkompatibilitäts-Systeme bei Pilzen. Viren und cytoplasmatische genetische Elemente in Pilzen und deren Anwendung für die biologische Bekämpfung von Pilzkrankheiten. Vertieftes Kennenlernen der Morphologie, Wirtspezifität und Ökologie der Mykorrhiza. Erlernen von methodischen Ansätzen zur Erfassung der Pilzdiversität. Messen des Mykorrhizainfektionspotentials eines Bodens. Vermittlung der Grundlagen des Pilzschutzes und dessen Umsetzung. Exkursion ins Pilzreservat La Chanéaz, FR.
Skript	Unterlagen zum Kurs werden abgegeben.
Literatur	Breitenbach J, Kränzlin F. 1980-2005. Pilze der Schweiz, Bände 1-6. Flammer R, Horak E. 2003. Giftpilze-Pilzgifte. Schwabe, Basel. Flück M. 2006. Pilzführer Schweiz. Haupt, Bern. Smith S.E, Read D.J. 1997. Mycorrhizal Symbiosis. Academic Press, 2nd ed.
Voraussetzungen / Besonderes	Der Blockkurs findet an der Eidg. Forschungsanstalt WSL in Birmensdorf statt. Der Wald vor der Haustüre des Institutes macht diesen Kurs besonders praxisnah. Erreichbarkeit mit Tram 14 bis Triemli, danach PTT-Bus 220 oder 350 bis Birmensdorf Sternen/WSL, oder mit S9 bis Birmensdorf SBB und mit PTT-Bus eine Station in Richtung Zürich bis Birmensdorf Sternen/WSL.
551-0359-00L	Plant Biochemistry Number of participants limited to 15. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	S. C. Zeeman, B. Pfister
Kurzbeschreibung	In diesem Blockkurs nehmen Studierende an aktuellen Forschungsprojekten zum Pflanzenmetabolismus unter der individuellen Betreuung durch (Post)Doktorierende teil. In einer begleitenden Serie von Vorlesungen werden der theoretische Hintergrund und die Verknüpfung der Projekte vorgestellt. In einer abschliessenden Posterpräsentation diskutieren die Studierenden ihre Projekte und Ergebnisse.
Lernziel	In diesem Blockkurs nehmen Studierende an Forschungsprojekten zum Pflanzenmetabolismus unter der individuellen Betreuung durch (Post-)Doktorierende teil.
Inhalt	Die Teilnahme an einem Projekt aus folgender Liste ist möglich: Photosynthese Stoffwechsel; Wie wird photo-assimilierter Kohlenstoff in den Pflanzen verteilt um das Pflanzenwachstum aufrecht zu erhalten? Biologie der Chloroplasten; Wie wird die Funktion der Chloroplasten in die der gesamten Zelle integriert? Stärkebiosynthese und -abbau; Wie werden komplexe, semi-kristalline Stärkekörner aus Einfachzuckern hergestellt und wie werden die so gespeicherten Kohlenhydrate beim Abbau der Stärkekörner freigesetzt? Stoffwechsel Regulation durch Protein-Protein Interaktion; Wie und warum interagieren Proteine miteinander die im Stärke Stoffwechsel involviert sind um Enzyme mit mehreren Untereinheiten und Enzymkomplexe zu bilden? Zucker Sensoren; Wie wissen Pflanzen wie viel Zucker vorhanden ist und wie beeinflusst dies die Entwicklung?
Skript	Kein Sript
Literatur	Beschreibungen der möglichen Projekte inklusive Literatur zum Einlesen werden vorab ausgeteilt.
551-1513-00L	Cancer Cell Signaling: Mechanisms, Targets and Therapeutic Approaches Number of participants limited to 10. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	W. Krek, W. Kovacs
Kurzbeschreibung	This course will consider the pathogenetic landscape of cancer, explore how abnormalities of cellular informationmanagement cause cancer and demonstrate how the integrated application of modern omics technologies, mouse cancer models and human pathology provides a foundation for developing individualized cancer therapeutics. The course combines practical work with discussions and presentations.
Lernziel	Insights into and overview about the genetic alterations that underlie different cancer types, the complex cancer cell circuitries governing tumor development, modern approaches used in contemporary basic and translational cancer research and sophisticated strategies to control individual cancers and combat drug resistance.
551-1147-00L	Bioactive Natural Products from Bacteria Number of participants limited to 8. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	J. Piel
Kurzbeschreibung	Lab course. In small groups projects of relevance to current research questions in the field of bacterial natural product biosynthesis are addressed.
Lernziel	Introduction to relevant subjects of the secondary metabolism of bacteria. Training in practical work in a research laboratory. Scientific writing in form of a research report.
Inhalt	Research project on bacteria that produce bioactive natural products (e.g., Streptomycetes, Cyanobacteria, uncultivated bacteria). The techniques used will depend on the project, e.g. PCR, cloning, natural product analysis, precursor feeding studies, enzyme expression and analysis.
Skript	none.
Literatur	Will be provided for each of the projects at the beginning of the course.
551-0351-00L	Membrane Biology Number of participants limited to 21. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	V. Korkhov, Y. Barral, B. Kornmann, U. Kutay, A. Rodriguez-Villalon, G. Schertler
Kurzbeschreibung	The course will introduce the students to the key concepts in membrane biology and will allow them to be involved in laboratory projects related to that broad field. The course will consist of lectures, literature discussions, and practical laboratory work in small groups. Results of the practical projects will be presented during the poster session at the end of the course.
Lernziel	The aim of the course is to expose the students to a wide range of modern research areas encompassed by the field of membrane biology.
Inhalt	Students will be engaged in research projects aimed at understanding the biological membranes at the molecular, organellar and cellular levels. Students will design and perform experiments, evaluate experimental results, analyze the current scientific literature and understand the relevance of their work in the context of the current state of the membrane biology field.
Skript	No script
Literatur	The recommended literature, including reviews and primary research articles, will be provided during the course
Voraussetzungen / Besonderes	The course will be taught in English. All general lectures will be held at ETH Hoenggerberg; special lectures will be organized by individual participating groups. Students will be divided into small groups to carry out experiments at ETH or at the Paul Scherrer Institute. Travel to the Paul Scherrer Insitute will be organized by car rental or public transportation.
551-1201-00L	Computational Methods in Genome and Sequence Analysis Number of participants limited to 5. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	A. Wutz
Kurzbeschreibung	This course aims to provide students with a comprehensive overview of computational methods for sequence analysis and assist with developing skills for application of computational approaches by experimental scientists in the life sciences.
Lernziel	Methods for analyzing animal genomes are increasingly becoming important for applications in human health and biotechnology suggesting that the experience will be useful to develop relevant expertise for a broad range of functions. Students will have the opportunity to advance their knowledge in programming by focusing on algorithms for genome and gene sequence analysis. A major goal of the course will be to lead the student to an independent and empowered attitude towards computational problems. For reaching this goal the students will work on an implementation of a solution for a set real-world problem in genome and sequence analysis under guided supervision.
Inhalt	•Understanding the information in biological sequences and quantifying similarity •Introduction to algorithms for sequence comparison and searches •Implementation of sequence comparisons and searches in Python •Accessing data formats associated with genome sequence analysis tasks •Understanding the anatomy of a real world sequence analysis project •Applying tools for sequence alignment and estimating error rates •Ability to implement a solution to a problem in sequence analysis using Python •Accessing genome annotation and retrieving relevant information in Pandas •Application of Genomic intervals and arrays for sequence analysis with HTSeq The course will consist of a series of lectures, assignments for implementing elementary tasks in Python, project development and discussion workshops, and 3 and a half week of practical work implementing a Pythons script as a solution to a real world problem associated with sequence analysis. At the end of the course students will explain their solutions and demonstrate the functionality of their implementations, which will then be discussed and commented on by the group. It is expected that students will be able to apply the knowledge to improve on concrete problems.
Voraussetzungen / Besonderes	- It is recommended to bring your own computer with a Python installation to the course - simple computers can be provided - Programming basics with Python

Blockkurse im 3. Semesterviertel Von 7.11.2017 13:00 Uhr bis 29.11.2017 17:00 Uhr
Nummer	Titel	Typ	ECTS	Umfang	Dozierende
551-0355-00L	Phytopathology Number of participants limited to 12. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	M. Maurhofer Bringolf, B. McDonald
Kurzbeschreibung	Theoretische und praktische Grundkenntnisse der Phytopathologie (Interaktion von Pflanzen und pathogenen Mikroorganismen, Morphologie und Lebensweise von pflanzenpathogenen Pilzen, Evolution von pflanzenpathogenen Pilzen, biologische Bekämpfung von Pflanzenkrankheiten)
Lernziel	Grundkenntnisse der Phytopathologie (Interaktionen zwischen Pflanzen und pflanzenpathogenen Mikroorganismen, Morphologie und Lebensweise von pflanzenpathogenen Pilzen, Evolution von pflanzenpathogenen Pilzenpflanzenpathogenen Pilzen, biologische Bekämpfung von Pflanzenkrankheiten) Einblick in aktuelle Forschungsprojekte in Theorie und Praxis
Inhalt	Praktischer Unterricht: Durchführung von Versuchen im Rahmen von aktuellen Forschungsprojekten in der Phytopathologie Makro- und mikroskopische Diagnostik von Pflanzenkrankheiten Theoretischer Unterricht: Einführung in die Phytopathologie. Schwerpunkte: Interaktionen zwischen Pflanzen und pflanzenpathogenen Mikroorganismen, Morphologie und Lebensweise von pflanzenpathogenen Pilzen, Evolution von pflanzenpathogenen Pilzen, biologische Bekämpfung von Pflanzenkrankheiten. Unterrichtssprache ist Englisch und Deutsch
Skript	wird am Anfang des Blockkurses verteilt
529-0739-01L	Biological Chemistry B: New Enzymes from Directed Evolution Experiments Number of participants limited to 12.	W	6 KP	7G	P. A. Kast
Kurzbeschreibung	During the block course in the fall semester, we will carry out biological-chemical enzyme evolution experiments using molecular genetic mutation technologies and in vivo selection in recombinant bacterial strains. The class with its very dense program consists of the practical course itself and an integrated series of seminar/lecture sessions.
Lernziel	All technologies used for the experiments will be explained to the students in theory and in practice with the goal that they will be able to independently apply them for the course project and in future research endeavors. After the course, an individual report about the results obtained has to be prepared.
Inhalt	The class deals with a specifically designed and genuine research project. We intend to carry out biological-chemical enzyme evolution experiments using molecular genetic mutation technologies and in vivo selection in recombinant bacterial strains. By working in parallel, teams of 2 participants each will generate a variety of different variants of a chorismate mutase. Individual enzyme catalysts will be purified and subsequently characterized using several different spectroscopic methods. The detailed chemical-physical analyses include determination of the enzymes' kinetic parameters, their molecular mass, and the integrity of the protein structure. The results obtained from the individual evolution experiments will be compared and discussed at the end of the class in a final seminar. We expect that during this lab course we will not only generate novel enzymes, but also gain new mechanistic insights into the investigated catalyst.
Skript	A script will be distributed to the participants on the first day of the course.
Literatur	General literature to "Directed Evolution" and chorismate mutases, e.g.: – Taylor, S. V., P. Kast & D. Hilvert. 2001. Investigating and engineering enzymes by genetic selection. Angew. Chem. Int. Ed. 40: 3310-3335. – Jäckel, C., P. Kast & D. Hilvert. 2008. Protein design by directed evolution. Annu. Rev. Biophys. 37: 153-173. – Roderer, K. & P. Kast. 2009. Evolutionary cycles for pericyclic reactions – Or why we keep mutating mutases. Chimia 63: 313-317. Further literature will be indicated in the distributed script.
Voraussetzungen / Besonderes	This laboratory course will involve experiments that require a tight schedule and, particularly in the second half, very long (!) working days. The maximum number of participants for the laboratory class is limited, but surplus applicants may contact P. Kast directly to have their names added to a waiting list. A valid registration is considered a commitment for attendance of the entire course, as involved material orders and experimental preparations are necessary and, once the class has started, the flow of the experiments must not be interrupted by individual absences. In case of an emergency, please immediately notify P. Kast. For more information see http://www.kast.ethz.ch/teaching.html, from where you can also download a flyer.
551-0336-00L	Methods in Cellular Biochemistry Number of participants limited to 18. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	P. Picotti, J. Fernandes de Matos, U. Kutay, M. Peter, K. Weis
Kurzbeschreibung	Students will learn about biochemical approaches to analyze cellular functions. The course consists of practical projects in small groups, lectures and literature discussions. The course concludes with the presentation of results at a poster session.
Lernziel	Students will learn to design, carry out and assess experiments using current biochemical and cell biological strategies to analyze cellular functions in a wide range of model systems. In particular they will learn novel imaging techniques along with biochemical approaches to understand fundamental cellular pathways. Furthermore, they will learn to assess strengths and limitations of the different approaches and be able to discuss their validity for the analysis of cellular functions.
Literatur	Documentation and recommended literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / Besonderes	This course will be taught in English.
551-1515-00L	Insulin Signaling Number of participants limited to 12. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	M. Stoffel
Kurzbeschreibung	Introduction to the physiological and biochemical action of insulin signaling and its role in the fasted/feeding response and in obesity and diabetes.
Lernziel	The students will obtain an overview about the current topics of research in insulin signaling and how it impacts on growth, metabolism and cell differentiation. They will learn to design experiments and use techniques necessary to analyze different aspects of insulin signaling,including physiological actions in whole animals as well as in tissue culture. Through lectures and literature seminars, they will learn about the open questions of insulin signaling research and discuss approaches to address these questions experimentally. In practical lab projects the students will perform physiological in vivo studies as well as biochemical experiments. Finally, they will learn how to present and discuss their data. Student assessment is a graded semester performance based on individual performance in the laboratory, a written exam and the lab data presentation.
752-4020-00L	Expt. Lebensmittelmikrobiologie für Biologen Maximale Teilnehmerzahl: 20 Voraussetzung: Als Vorbereitung für das Praktikum, wird der Besuch der LE Lebensmittel-Mikrobiologie (752-4005-00L) dringend empfohlen.	W	6 KP	7G	M. Schuppler, M. Loessner, M. Schmelcher
Kurzbeschreibung	Vermittlung des praktischen Basiswissens zur Diagnostik von Mikroorganismen in Lebensmitteln. Die vielfältigen Laborexperimente werden durch theoretische Einführungen ergänzt. Der Schwerpunkt liegt auf modernen Methoden der molekularen Diagnostik und dem Schnellnachweis von Krankheitserregern in Lebensmitteln in Anlehnung an aktuelle Forschungsthemen des Labors für Lebensmittelmikrobiologie.
Lernziel	Einführung in Methodik und Techniken der Lebensmittelmikrobiologie
Inhalt	Vermittlung des praktischen Basiswissens zur mikrobiologischen Untersuchung von Lebensmitteln anhand der Durchführung sowohl klassischer Nachweisverfahren als auch moderner Methoden zur molekularen Diagnostik und zum Schnellnachweis von Krankheitserregern in Lebensmitteln.
Skript	Skripte werden zu Beginn des Praktikums ausgegeben
Literatur	- Krämer: "Lebensmittel-Mikrobiologie" (Ulmer; UTB) - Süssmuth et al.: "Mikrobiologisch-Biochemisches Praktikum" (Thieme)
Voraussetzungen / Besonderes	Wichtiger Hinweis! Im Praktikum wird unter anderem mit dem Krankheitserreger Listeria monocytogenes gearbeitet, welcher eine erhebliche Gefährdung für Schwangere darstellt. Aus Gründen der Biosicherheit ist daher eine Teilnahme am Praktikum bei bestehender Schwangerschaft nicht möglich!
551-0363-00L	Complex Carbohydrates - Biosynthesis, Structure & Function Number of participants limited to minimum 2 and maximum 8. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	M. Aebi, T. Keys
Kurzbeschreibung	In vitro & in vivo Experimente führen in die aktuelle Forschung über Biosynthese, Struktur & Funktion von protein-gebundenen Glykanen in verschiedenen pro- und eukaryotischen Mikroorganismen ein.
Lernziel	Die Teilnehmer sind vertraut mit der Biosynthese, Struktur und Funktion von N-Glykanen in Mikroorganismen und den Methoden zur Untersuchung derselben.
Inhalt	* Themen: Biosynthese von Asparagin-gebundenen Glykanen in Pro- und Eukaryoten; Struktur der Glykane in verschiedenen Organismen; Methoden zur Analyse der Glykanstruktur; Funktion von Glykanen in der Proteinqualitätskontrolle * Einführende Vorlesungen in die behandelten Themen * Seminar mit Präsentation und Besprechung aktueller Veröffentlichungen * Experimente, die Themen aus der aktuellen Forschung der Arbeitsgruppe beispielhaft darstellen
551-0117-00L	Plant Volatiles in Plant Insect Interactions Findet dieses Semester nicht statt. Number of participants limited to 16. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	C. De Moraes
Kurzbeschreibung	During the course students will become familiar with methods for the collection and analysis of plant-derived volatile organic compounds and explore the role of these compounds in mediating plant-insect interactions.
Lernziel	The course will cover six main topics that will be connected throughout the experimental phase: 1) Plant volatile biosynthesis and classification 2) Insect olfactory physiology 3) Volatile-mediated plant-herbivore interactions 4) Volatile-mediated multitrophic interactions 5) Manipulation of plant volatile emission by vector- borne disease agents 6) Methods for volatile collection and analysis The lab practical will be performed in a system consisting of the cabbage butterfly Pieris brasicae, its host plant Brassica oleracea (Brussels sprouts), and the parasitoid wasp Cotesia glomerata (natural enemy of P. brasicae). Students will collect volatiles from herbivore-damaged and undamaged plants and learn how to identify and quantify these compounds through gas chromatography coupled with mass spectrometry and flame ionization detection (GG-MS-FID). Afterwards, they will be able to compare volatile emissions from herbivore-damaged and undamaged plants and identify important volatile compounds associated with herbivory. Finally, students will evaluate the effect of herbivore-induced volatile compounds on the behavior of the herbivore (P. brassicae) and its natural enemy (C. glomerata), using different behavioral assays, inculding Y-tube olfactometers and wind tunnels.
Skript	No script
Literatur	The recommended literature, including reviews and primary research articles, will be provided during the course.

Blockkurse im 4. Semesterviertel Von 30.11.2017 08:00 Uhr bis 22.12.2017 17:00 Uhr
Nummer	Titel	Typ	ECTS	Umfang	Dozierende
551-0361-00L	Biologie der Moose und Farne Maximale Teilnehmerzahl: 20 Die Belegung erfolgt nur über das Studiensekretariat D-BIOL.	W	6 KP	7G	R. Holderegger, A. L. Bergamini
Kurzbeschreibung	Moose: Basiswissen zu Morphologie, Ökologie, Biogeographie und Gefährdung; Kennenlernen häufiger Arten; Anleitung zur selbständigen Bestimmungsarbeit; Exkursion. Farne: Vermittlung grundlegender Kenntnisse zu Generationszyklus, Evolution und Ökologie; Kennenlernen der schweizerischen Farnflora; Exkursionen.
Lernziel	Moose: Basiswissen zu Morphologie, Ökologie, Biogeographie und Gefährdung von Moosen; Kennenlernen häufiger Arten; Anleitung zur selbständigen Bestimmungsarbeit. Farne: Vermittlung grundlegender Kenntnisse zu Generationszyklus, Evolution und Ökologie der Farne; Kennenlernen der schweizerischen Farnflora.
Inhalt	Moose: Systematik und Morphologie der Horn-, Leber- und Laubmoose sowie weiterführende Themen zu Ökologie, Biogeographie, Diversität und Gefährdung; eine ganztägige Exkursion. Teil Farne: Generationszyklus; evolutionäre Gruppen der Farne, Bärlappe und Schachtelhalme; Fortpflanzungsbiologie; Mikro- und Makroevolution; Ökologie; ganztägige und halbtägige Exkursionen.
Skript	Unterrichtsmaterial wird abgegeben.
Literatur	Vanderpoorten A. and Goffinet B. 2009. Introduction to Bryophytes. Cambridge University Press, Cambridge (nicht obligatorisch).
Voraussetzungen / Besonderes	Teilnehmende müssen ein Poster zu einem speziellen Thema vorstellen. Note besteht aus Poster Präsentation und Mitarbeit während des Kurses. Voraussetzungen: Erst- und Zweitjahres Kurse in Botanik und Evolution.
551-1309-00L	RNA-Biology Number of participants limited to 20. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	B. Mateescu, F. Allain, C. Beyer, J. Hall, R. Santoro, O. Voinnet, K. Weis, A. Wutz
Kurzbeschreibung	Introduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells.
Lernziel	The students will obtain an overview about the diversity of current RNA-research. They will learn to design experiments and use techniques necessary to analyze different aspects of RNA biology. Through lectures and literature seminars, they will learn about the burning questions of RNA research and discuss approaches to address these questions experimentally. In practical lab projects the students will work in one of the participating laboratories. Finally, they will learn how to present and discuss their data in an appropriate manner. Student assessment is a graded semester performance based on individual performance in the laboratory, the written exam and the poster presentation.
Literatur	Documentation and recommended literature will be provided at the beginning and during the course.
Voraussetzungen / Besonderes	The course will be taught in English.
551-1511-00L	Parallels Between Tissue Repair and Cancer Number of participants limited to 15. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	S. Werner, U. Auf dem Keller, M. Bordoli, M. Schäfer
Kurzbeschreibung	This course aims at the understanding of the cellular and molecular mechanisms underlying tissue repair processes in response to different insults. The focus will be on repair of the skin and the liver. In addition, we will highlight the parallels and differences between tissue repair and cancer.
Lernziel	To learn the cellular and molecular principles underlying tissue repair processes, in particular in the skin and in the liver, and the parallels and differences to cancer. To learn modern technologies in Molecular and Cellular Biology as well as Histology and to use these technologies to study questions related to mechanisms underlying tissue repair and cancer.
Inhalt	This course aims at the understanding of the cellular and molecular mechanisms underlying tissue repair processes in response to different insults. The focus will be on repair of the skin and the liver. In addition, we will highlight the parallels and differences between tissue repair and cancer. Experimental approaches include biochemical studies, molecular and cellular studies using cultured cell lines and primary cells, as well as analysis of murine and human tissues. The course combines practical work with lectures, discussions, project preparations and presentations.
Skript	siehe Lernmaterialien
551-0371-00L	Growth Control: Insights from Yeast and Flies Number of participants limited to 8. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	H. Stocker, R. C. Dechant, M. Peter
Kurzbeschreibung	All organisms have to control their growth in accordance with environmental conditions. This course focuses on the analysis of growth regulation in the model organisms yeast and Drosophila. The participants will perform experiments in small teams to study insulin/TOR signaling as a key regulator of cellular growth. A particular focus will be the discussion of current research.
Lernziel	The aims of the block course are that participants (I) understand the function and evolution of insulin/TOR signaling (II) learn how genetic approaches in different organisms contribute to the understanding of human diseases such as cancer (III) will get familiarized with reading and discussing research articles (IV) get a first exposure to current research.
Inhalt	The block course consists of (I) experiments: Teams of two students each will join research labs to work on current projects focusing on growth regulation in both single-cell eukaryotes (yeast) and multicellular animals (Drosophila). The students will present their projects and results to their colleagues. (II) lectures on growth regulation in yeast and Drosophila. (III) journal clubs to discuss recent literature.
Skript	Lecture handouts
Literatur	Original research articles will be discussed during the course.
551-1403-00L	Imaging Bacterial Cells in a Native State by Electron Cryotomography Number of participants limited to 3. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	M. Pilhofer
Kurzbeschreibung	The goal is to acquire the techniques to image bacteria by electron cryotomography, resolving their structure in a native state, in 3D, and to macromolecular resolution. In a small group, students will perform wet lab experiments, data collection with stat-of-the-art equipment, data processing and analyses. The key method and its application in bacterial cell biology will be introduced by lectures
Lernziel	Students will acquire the skills to cultivate bacteria, plunge-freeze samples for cryotomography, collect data using an electron cryomicroscope, process raw data, analyze tomograms, perform subtomogram averaging, model structures of interest, and generate movies for visualization. https://www.mol.biol.ethz.ch/groups/pilhofer_group/
551-1417-00L	In Vivo Cryo-EM Analysis of Dynein Motor Proteins Number of participants limited to 3. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	T. Ishikawa
Kurzbeschreibung	Motor proteins convert chemical energy into mechanical motion. In this block course, we study dynein motor proteins in cilia. Dynein causes conformational change upon ATP hydrolysis and finally generate ciliary bending motion. Participants will analyze cryo-EM data of cilia and visualize in vivo 3D structure of dynein to learn how motor proteins function in the cell.
Lernziel	The goal of this course is to be familiar with structural biology techniques of cryo-electron tomography and single particle cryo-EM studies on motor proteins. The main focus is 3D image analysis of cryo-EM datasets acquired by highest-end microscopes. Participants will learn structure-function relationship at various scales: how the conformational change of motor proteins causes mechanical force and generates cellular motility.
Inhalt	Motor proteins, such as dynein, myosin and kinesin, hydrolyze ATP to ADP and phosphate to convert chemical energy to mechanical motion. Their function is essential for intracellular transport, muscle contraction and other cellular motility as well as cell division. Motor proteins have been major targets of biophysical studies. There exist questions from atomic to tissue levels – how ATP hydrolysis causes conformational change of motor proteins; how their motion is regulated by calcium, phosphorylation and other factors; how motions of multiple motor proteins are coordinated to generate cellular motility. Structural biology has been playing central roles to answer these questions. X-ray crystallography and single particle cryo-EM address structural analysis at atomic resolution and try to reveal molecular mechanism of conformational change. Cryo-electron tomography analyze localization and 3D structure of motor proteins in the cell to explain how motions of molecular motors happen in the context of cellular environment and are integrated into cellular motion. In this course, we study dyneins in cilia. Cilia are force-generating organelles, made by nine microtubules and thousands of dyneins. Dynein hydrolyzes ATP and undergoes conformational change, generating linear motion with respect to the microtubule. As a whole system, cilia integrate motions of these dyneins and orchestrate beating motion. To explain ciliary motion at molecular level, we need to know dynein conformational change in the cellular context. Cryo-electron tomography is recently developed technique to study molecular structures in vivo and therefore a suitable method to study dynein in cilia. Recently spatial resolution of these cryo-EM techniques was dramatically improved, driven by development of new types of detectors and electron optics. The participants of this course will learn a program to analyze cryo-electron tomography and single particle cryo-EM data, acquired by highest-end electron microscopes and detectors in ETH and other places, and reconstruct 3D structure (tomogram) of cilia from various organisms (from green algae to human). They will further learn a program to study molecular structures from these tomograms (called subtomogram averaging) and apply it to reconstruct high-resolution 3D structure of dyneins, microtubules and regulatory proteins. This practical course is therefore mainly computational, but we will also provide students a chance of cilia preparation from green algae, cryo-EM data collection using an electron microscope in PSI and site-visit of highest-end electron microscope facility in ETH.
Skript	Scripts will be distributed during the course.
Literatur	An overview is given in the following review articles. Further literature will be indicated during the course. Ishikawa (2017) “Axoneme structure from motile cilia” Cold Spring Harb. Perspect Biol. 9. doi: 10.1101/cshperspect.a028076. Ishikawa (2017) “Cryo-electron tomography of motile cilia and flagella” Cilia 4, 3. doi: 10.1186/s13630-014-0012-7.

Blockkurse in der 1. Semesterhälfte Von 19.9.2017 13:00 Uhr bis 3.11.2017 17:00 Uhr.
Nummer	Titel	Typ	ECTS	Umfang	Dozierende
701-2437-01L	Limnoökologie (inkl. zwei praktischen Kursen) Der Kurs «701-2437-01L Limnoökologie» muss im Blockkurstool als «BIO 309 Limnoecology» angemeldet werden.	W	12 KP	3V + 6U + 4P	J. Jokela, P. Spaak, F. Altermatt, K. J. Räsänen, C. T. Robinson
Kurzbeschreibung	Dieser Kurs verbindet Limnologie (Süsswasser im allgemeinen Sinn) mit ökologischen und evolutionären Konzepten. Dabei werden Flüsse, Grundwasser und Seen behandelt. Der Blockkurs besteht aus einem Vorlesungsteil, Forschungsarbeiten, Exkursionen und aus zwei Bestimmungskursen zu einheimischen Makroinvertebraten sowie Kryptogamen und Mikroinvertebraten.
Lernziel	Während diesem Kurs erhalten die Studierenden einen Überblick über die typischen Süsswasserökosysteme. Nach diesem Kurs sind Sie fähig Anpassungen der Organismen an ihre Habitate sowie die Interaktionen (z.B. Nahrungsnetz) zwischen den Organismen zu verstehen. Während dem experimentellen Teil lernen Sie, wie man aquatische Ökosysteme untersucht und ihre Interaktionen verfolgt. Sie werden biologische und physikalische Daten erheben, interpretieren und wissenschaftlich präsentieren. Zudem werden Sie fähig sein mit Bestimmungsschlüsseln umzugehen, sowie die wichtigsten Vertreter in der Schweiz (Makroinvertebraten, Mikroinvertebraten und Krypotgamen) zu benennen.
Inhalt	Dieser Kurs beinhaltet Vorlesungen, einen experimentellen Teil, Feldexkursionen sowie zwei Bestimmungskurse (Makroinvertebraten und Mikroinvertebraten & Kryptogamen). Vorlesung: Der Vorlesungsteil deckt die Ökologie und Evolution von aquatischen Organismen im fliessenden und stehenden Wasser ab. Die Themengebiete umfassen: Adaption, Ausbreitungsmuster, biotische Interaktionen, konzeptionelle Paradigmen der Süsswasserökosysteme sowie angewandte Fallstudien und experimentelle Untersuchungen von ökologischen und evolutiven Prozessen in Süssgewässer. Praktischer Teil: Der praktische Teil beinhaltet eine Exkursion an den Greifensee und eine dreitägige Exkursion an die Glatt bei Niederuzwil, wo selbständig kleine Forschungsprojekte durchgeführt werden. In einem Forschungspraktikum werden Sie zudem die Möglichkeit haben, in Forschungsgruppen der Eawag eigenen Kleingruppen-Projekten nachzugehen. Bestimmungskurse: Die zwei taxonomischen Bestimmungskurse behandeln aquatische Wirbellose (z.B. Krebstiere, aquatische Insekten, Zooplankton) sowie Kryptogamen. Das Ziel ist es, die typischen aquatischen Taxa der Schweiz kennenzulernen, diese mit Hilfe von Bestimmungsschlüsseln zu identifizieren und eine Idee zu erhalten, wie diese Organismen in der Forschung und in der Praxis (Bioindikation) eingesetzt bzw. untersucht werden. Die Originalsprache des Kurses ist Deutsch.
Skript	Handouts und Folien werden im Kurs laufend abgegeben.
Voraussetzungen / Besonderes	Die Teilnehmerzahl des Doppelblockkurses ist auf 14 Biologiestudierende beschränkt. Der Kurs beinhaltet eine mehrtägige Exkursion an die Glatt bei Niederuzwil vom 4.-6.Oktober 2017.

Blockkurse in den Semesterferien
Nummer	Titel	Typ	ECTS	Umfang	Dozierende
551-0438-00L	Protein Folding, Assembly and Degradation Number of participants limited to 14. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	R. Glockshuber, E. Weber-Ban
Kurzbeschreibung	Students will carry out defined research projects related to the current research topics of the groups of Prof. Glockshuber and Prof. Weber-Ban. The topics include mechanistic studies on the assembly of adhesive pili from pathogenic bacteria, disulfide bond formation in the bacterial periplasm, ATP-dependent chaperone-protease complexes and formation of amyloid deposits in Alzheimer's disese.
Lernziel	The course should enable the students to understand and apply biophysical methods, in particular kinetic and spectroscopic methods, to unravel the mechanism of complex reactions of biological macromolecules and assemblies in a quantitative manner.
Inhalt	The students will be tutored in their experimental work by doctoral or postdoctoral students from the Glockshuber or Weber-Ban group. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as excercises on the numeric evaluation of biophysical data, and literature work. Participation in one of the following projects will be possible: Projects of the Glockshuber group: - Purification, biophysical characterization and structure determiation of enzymes required for disulfide bond formation in the periplasm of Gram-negative bacteria. - Mechanistic studies on the assembly of type 1 pili from pathogenic Escherichia coli strains. In vitro reconstitution of pilus assembly from all purified components. Characterization of folding, stability and assembly behaviour of individual pilus subunits. - Identification of intermediates in the aggregation of the human Abeta peptide Experimental work on these projects involves - Molecular cloning, recombinant protein production in E. coli and protein purification - Protein crystallization - Thermodynamic and kinetic characterization of conformational changes in proteins and protein-ligand interactions by fluorescence and circular dischoism spectroscopy - Analysis of rapid reactions by stopped-flow fluorescence - Negative-stain electron microscopy - Light scattering Projects of the Weber-Ban group: - Generation and purification of site-directed variants of the E. coli ClpA/P protease and chaperone-proteasome complexes from other organisms, their biophysical characterization, including rapid kinetics by stopped-flow methods, ATPase activity measurtements, negative-stain electron microscopy and light scattering
Skript	No script
Literatur	Literature related to the individual projects will be provided on the first day of the course.
Voraussetzungen / Besonderes	Attendance of the concept course "Biomolecular Structure and Mechanism I: Protein Structure and Function" (551-0307-00L) in the autumn semester is highly recommended for acquiring the theoretical background to this block course.
551-1709-00L	Genomic and Genetic Methods in Cell and Developmental Biology Number of participants limited to 11. The enrolment is done by the D-BIOL study administration.	W	6 KP	7G	A. Wutz, C. Beyer, M. Kopf, T. Schroeder, G. Schwank
Kurzbeschreibung	This course aims to provide students with a comprehensive overview of mammalian developmental biology and stem cell systems both on the theoretical as well as the experimental level. Centering the course on genetic and genomic methods engages the students in contemporary research and prepares for future studies in the course of semester and master projects.
Lernziel	- Understanding mammalian development - Introduction to stem cells systems - Working with cultured cells - Translational aspects of mammalian cell biology
Inhalt	The course will consist of a series of lectures, assay assignments, project development and discussion workshops, and 2 and a half week of lab work with different mammalian cell systems embedded in real life research projects. At the end of the course students will take an exam consisting of questions on the topic of the lectures and workshops. It is expected that students will be able to apply the knowledge to concrete problems.

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