Search result: Catalogue data in Spring Semester 2019

Number	Title	Type	ECTS	Hours	Lecturers
Biology Bachelor
2. Year, 4. Semester
Core Courses
529-1024-00L	Physical Chemistry II (for Biology and Pharmacy)	O	4 credits	2V + 1U	R. Riek
Abstract	Kinetics of chemical and biochemical reactions, in particular catalyzed reactions. Surface- and transport-phenomena, characterization of open systems.
Objective	Knowledge on the basics of time dependent process in chemical and biological systems.
Content	Grundbegriffe: Stofftransport, Transport in kontinuierlichen Systemen, Wärmeleitung, Viskosität von Gasen, Laminare Strömung durch Rohre, Ionenleitfähigkeit, Elektrisch geladene Grenzflächen, Elektrophorese, Sedimentation im Zentrifugalfeld, Eigenschaften der Plasmamembran, Transport durch Membranen, Membranpotentiale Reaktionsgeschwindigkeitsgesetze, Elementarreaktionen und zusammengesetzte Reaktionen, Molekularität, Reaktionsordnung, Experimentelle Methoden der Reaktionskinetik. Einfache Theorie chemischer Reaktionen: Temperaturabhängigkeit der Gleichgewichtskonstante und Arrheniusgleichung, Stosstheorie, Reaktionsquerschnitte, Theorie des Übergangszustandes. Zusammengesetzte Reaktionen: Reaktionsmechanismen und komplexe kinetische Systeme, Näherungsverfahren. Enzymkinetik. Kinetik geladener Teilchen. Diffusion und diffusionskontrollierte Reaktionen.
Lecture notes	Handouts werden in der Vorlesung verteilt
Literature	Adam, G., Läuger, P., Stark, G., 2003: Physikalische Chemie und Biophysik, 4. Aufl., Springer Verlag, Berlin.
Prerequisites / Notice	Voraussetzungen: Physikalische Chemie I
551-0104-00L	Fundamentals of Biology II Registrations via myStudies until 30.1.2019 at the latest. Subsequent registrations will not be considered.	O	8 credits	8P	M. Gstaiger, E. Dultz, C. H. Giese, W. Kovacs, D. Santelia, H. Stocker, U. Suter, S. Werner
Abstract	This introductory Laboratory course introduces the student to the entire range of classical and modern molecular biosciences. In the second year (Praktikum GL Bio II) the students will perform three praktikum days in: - Molecular Biology - Plant Physiology - Genetics and - Cell Biology II. (total of 12 experiments) Each experiment takes one full day.
Objective	Introduction to theoretical and experimental biology Moodle www-link for general Praktikum-information and course material: Moodle The general Praktikum information (Assignment list, Instructions and Schedule & Performance Sheet) will also be sent to the students directly (E-mail).
Content	The class is divided into four blocks: Cell Biology II, Genetics, Molecular Biology and Plant Physiology. One block lasts three weeks. CELL BIOLOGY II: - Cells: Cell types & staining methods, cell fusion & cell motility, - Tissue and development: histology of mice embryos & embryogenesis - Repair mechanisms: DNA repair & wound healing, GENETICS: - Yeast genetics - Drosophila genetics - Human genetics MOLECULAR BIOLOGY - Molecular biology & protein crystallization - Enzyme kinetics - Redox potential & stability of a protein PLANT PHYSIOLOGY: - Plants and light - Phytohormones and other growth factors - Molecular biology of systemic gene silencing - Literature and presentations The students will also prepare short presentations (approx. 10 min) of the various topics within this course.
Lecture notes	Laboratory manuals CELL BIOLOGY II - The protocols can be downloaded from: Moodle MOLECULAR BIOLOGY: - The protocols can be found from: Moodle PLANT PHYSIOLOGY - The protocols can be found from: Moodle GENETICS - The protocols can be found from: Moodle
Prerequisites / Notice	THE PRAKTIKUM RULES: Your attendance is obligatory and you have to attend all 12 Praktikum days. Absences are only acceptable if you are able to provide a Doctor’s certificate. The original Dr's certificate has to be given to Dr. M. Gstaiger (HPM F43) within five days of the absence of the Praktikum day. If there will be any exceptional or important situations then you should directly contact the Director of Studies of D-Biol, who will decide if you are allowed to miss a Praktikum day or not. HIGHLY IMPORTANT!! 1. Due to the increased number of students, the official Praktikum registration has to be done, using myStudies, preferably at the end of HS18 but not later than Wednesday January 30, 2019. 2. Later registration is NOT possible and can NOT be accepted! 3. The course registration for FS19 is usually possible at the end of HS18 and you will obtain an E-mail from the Rectorate when the course registration using myStudies is possible. Students can register for a practice group via myStudies. As soon as the course unit is registered in myStudies, a text box appears indicating that a group can be selected. Accordingly, students can select a group in the next step. If more than 180 students register, the surplus students will be placed on a waiting list and then allocated by the course responsible. The Praktikum GL BioII FS19 will take place during the following days and therefore, you have to make sure already now that you do not have any other activities & commitments during these days: PRAKTIKUM DAYS DURING FS19 (Fridays): 22.2 / 1.3 / 8.3 / 15.3 / 22.3 / 29.3 / 5.4 / 12.4 / 3.5 / 10.5 / 17.5 / 24.5 No Praktikum during the Easter break: 19.4.-26.4. 2019
551-1298-00L	Genetics, Genomics, Bioinformatics	O	4 credits	2V + 2U	E. Hafen, C. Beyer, B. Christen, U. K. Genick, J. Piel, R. Schlapbach, G. Schwank, S. Sunagawa, K. Weis, A. Wutz
Abstract	The course provides the basis of modern genetics, genomics and bioinformatics. A special focus is placed on the use of these tools for the understanding of biological processes in bacteria, model organisms and humans. The unit uses the principle of blended learning consisting of self-study modules in Moodle, tasks and input lectures by experts from the department.
Objective	At the end of this course you know the most important genetic tools in different organisms. You can use the essential methods in bioinformatics by using online tools. You know the advantages and disadvantages of various model organisms to understand biological processes. You know the various mutagenesis methods and other tools to disrupt gene function and can discuss their merits and drawbacks. You are aware of the difficulties in choosing a phenotype for selection in a mutagenesis experiment. Finally, you can describe how you would study a specific biological process by choosing a model organism and the appropriate genetic or genomic tools.
Content	The appearance and function of an organism (phenotype) is determined by the interplay between its genome (genotype) and the environment: Genotype + environment = phenotype. Understanding these interactions to the point where we can ultimately predict the phenotype from knowledge of the genotype and environmental factors is one oft the great challenges of biology. In the course Bio IA you learnt about the composition and function of the genome and how it is inherited. The goal of this course is that you learn how genetic, genomic and bioinformatics methods are used to understand biological processes (the connection between genotype and phenotype). In the first two weeks you will renew and deepen your knowledge of the basic principles of genetics and genomics in interactive learning modules on the Moodle platform. This is followed by an introduction of the basic tools of bioinformatics. You learn to search for specific genome sequences, to align them and to construct pedigrees of related genes. After you have mastered the basic principles you will learn how to study biological processes either by inactivating specific genes or by randomly mutagenizing the entire genome. You will be introduced to different model organisms (bacteria, yeast, Drosophila, mouse) and humans. Conventional genetic methods rely on the alteration of the function of single genes and on the observation of the effect on the organism (phenotype). Based on the observed phenotype one deduces the normal function of the gene. This is a strong simplification since, even if environmental factors are controlled, phenotypes are very rarely controlled by a single gene. It is therefore important to understand the influence of the entire genome in conjunction with environmental factors on a given phenotype (e.g. a human disease). Modern methods in genomics now permit first approaches in this direction. Therefore, the focus of the second part of the unit is on genome-wide association studies. You learn, how the influence of the entire genome on a specific phenotype is detected and what challenges are involved in the analysis and the interpretation of the results. We will examine these methods in model organisms and humans. You will also learn how the genome of cancer cells changes under the constant selection for these cells to survive and how this genome analysis provides new insights into diagnosis and therapy. This course is based on active learning. Each week consists of a learning unit with clearly defined learning goals. In the first two hours you will learn the basics from texts, videos and questionnaires on the Moodle platform. In the third lecture an expert on the topic of the week (e.g. genetic screens in yeast) from the department will give an input lecture that builds on the basic knowledge that you acquired. In the fourth lecture you will discuss the tests and topics of the week with the expert. During the semester you will have access to assistants and lecturers via the Moodle online forum. At the beginning of the learning unit you will take a short multiple-choice test on the content of the course. This formative assessment does not count for your final grade but gives you and us a way to determine where you stand also in relation to your fellow students. A similar formative assessment test will be given at the end of the semester. In this way, we can determine the learning gain during the course and obtain a quantitative feedback on the course. The exam is based on the learning goals of the individual chapters and the questions in the formative assessments.
Lecture notes	The learning material and slides of the input lectures are available on Moodle. There you will also find further information (articles, links, videos).
Literature	All texts and references will be available on Moodle. To follow the most recent developments in this rapidly evolving field follow the following experts on Twitter: @dgmacarthur @EricTopol und/oder @ehafen
Prerequisites / Notice	The course builds on the course Bio IA, in particular on that course's content regarding genetics and genomics. The course is based on self-learning units on Moodle, input lectures by experts from D-BIOL and exercises.
551-0108-00L	Fundamentals of Biology II: Plant Biology	O	2 credits	2V	O. Voinnet, W. Gruissem, S. C. Zeeman
Abstract	Water balance, assimilation, transport in plants; developmental biology, stress physiology.
Objective	Water balance, assimilation, transport in plants; developmental biology, stress physiology.
Lecture notes	Plant Biology: Handouts of the powerpoint presentation will be distributed. It can also be viewed in a password-protected web link.
Literature	Smith, A.M., et al.: Plant Biology, Garland Science, New York, Oxford, 2010
551-0110-00L	Fundamentals of Biology II: Microbiology	O	2 credits	2V	J. Vorholt-Zambelli, W.‑D. Hardt, J. Piel
Abstract	Bacterial cell biology, molecular genetics, gene regulation, growth physiology, metabolism (Bacteria and Archaea), natural products, microbial interactions
Objective	Basic principles of cell structure, growth physiology, energy metabolism, gene expression and regulation. Biodiversity of Bacteria and Archaea. Phylogeny and evolution.
Content	Bacterial cell biology, molecular genetics, gene regulation, growth physiology, metabolism (Bacteria and Archaea), natural products, microbial interactions
Literature	Brock, Biology of Microorganisms (Madigan, M.T. and Martinko, J.M., eds.), 14th ed., Pearson Prentice Hall, 2015

Elective Blocks
Biodiversity
Number	Title	Type	ECTS	Hours	Lecturers
551-1174-00L	Systems Biology	O	4 credits	2V + 2U	U. Sauer, K. M. Borgwardt, J. Stelling, N. Zamboni
Abstract	The course teaches computational methods and first hands-on applications by starting from biological problems/phenomena that students in the 4th semester are somewhat familiar with. During the exercises, students will obtain first experience with programming their own analyses/models for data analysis/interpretation.
Objective	We will teach little if any novel biological knowledge or analysis methods, but focus on training the ability of use existing knowledge (for example from enzyme kinetics, regulatory mechanisms or analytical methods) to understand biological problems that arise when considering molecular elements in their context and to translate some of these problems into a form that can be solved by computational methods. Specific goals are: - understand the limitations of intuitive reasoning - obtain a first overview of computational approaches in systems biology - train ability to translate biological problems into computational problems - solve practical problems by programming with MATLAB - make first experiences in computational interpretation of biological data - understand typical abstractions in modeling molecular systems
Content	During the first 7 weeks, the will focus on mechanistic modeling. Starting from simple enzyme kinetics, we will move through the dynamics of small pathways that also include regulation and end with flux balance analysis of a medium size metabolic network. During the second 7 weeks, the focus will shift to the analysis of larger data sets, such as metabolomics and transcriptomics that are often generated in biology. Here we will go through multivariate statistical methods that include clustering and principal component analysis, ending with first methods to learn networks from data.
Lecture notes	Kein Skript
Literature	The course is not taught by a particular book, but two books are suggested for further reading: - Systems Biology (Klipp, Herwig, Kowald, Wierling und Lehrach) Wiley-VCH 2009 - A First Course in Systems Biology (Eberhardt O. Voight) Garland Science 2012
376-0152-00L	Anatomy and Physiology II	O	5 credits	4V	M. Ristow, K. De Bock, M. Kopf, L. Slomianka, C. Spengler
Abstract	Basic knowledge of the anatomy and physiology of the gastrointestinal tract, endocrine organs, urinary system and the reproductive system. Knowlewdge of the basic mechanisms of pathobiology. Study of all human tissues and selected organs by examining slides under the light microscope.
Objective	Foundations of human anatomy and physiology and basics of clinical pathophysiology
Content	Short overview of human anatomy, physiology and general pathology. 3rd semester: Principles of histology and embryology. Anatomy and physiology: nervous system, muscle, sensory organs, circulatory system, respiratory system. 4rd semester: Anatomy and physiology: gastrointestinal tract, endocrine system, metabolism and thermoregulation, integumentary system, blood and immune system, urinary system, circadian rhythm, reproductive system, pregnancy and birth.
Literature	Anatomie: Martini, Timmons, Tallitsch, "Anatomie", Pearson; oder Schiebler, Korf, "Anatomie", Steinkopff / Springer; oder Spornitz, "Anatomie und Physiologie, Lehrbuch und Atlas für Pflege-und Gesundheitsfachberufe", Springer Physiologie: Thews/Mutschler/Vaupel: Anatomie, Physiologie, Pathophysiologie des Menschen, Wissenschaftliche Verlagsgesellschaft, Stuttgart oder Schmidt/Lang/Thews: Physiologie des Menschen, Springer-Verlag, Heidelberg
Prerequisites / Notice	Der Besuch der Anatomie und Physiologie I - Vorlesung ist Voraussetzung, da die Anatomie und Physiologie II - Vorlesung auf dem Wissen der im vorangegangenen Semester gelesenen Anatomie und Physiologie I - Vorlesung aufbaut.
701-0360-00L	Systematic Biology: Plants	O	5 credits	2V + 3P	A. Leuchtmann
Abstract	The lecture provides an overview of the diversity of ferns and seed-plants. The fundamentals of systematics are given considering morphological, phylogenetic and ecological aspects. Regarding plant species, emphasis is laid on the flora of Switzerland, but also examples of pharmaceutical relevance and crop plants will be included.
Objective	Students know: - the fundamentals of plant systematics - the higher-level plant groups based on morphological and biological characteristics - selected families of flowering plants - selected species and their ecology, with special focus on the flora of Switzerland - examples of medicinal and crop plants - ecological factors of sites and the most important vegetation types of the lowlands.
Content	Die Vorlesung gibt einen Überblick über Moose, Farne, Gymnospermen und Angiospermen. Ausgewählte Familien der Angiospermen werden ausführlich behandelt. Weitere Themen sind Grundlagen der Pflanzensystematik, Generationswechsel, phylogenetische Stammbäume, morphologische Begriffe, sowie Lebensweise und Ökologie der Pflanzen. Anhand ausgewählter Beispiele wird auf die Bedeutung der Pflanzen als Arznei-, Zeiger- und Nutzpflanzen eingegangen. Zudem wird eine Übersicht über Standorteigenschaften und Vegetation des Tieflandes in der Schweiz gegeben. Im praktischen Teil lernen die Studierenden Merkmale von Blütenpflanzen zu analysieren und üben das Bestimmen von Pflanzenarten. Auf Exkursionen werden Artkenntnisse vermittelt und ein Einblick gegeben in Flora und Vegetation ausgewählter Standorte im Schweizer Mittelland, wobei auch einheimische Arzneipflanzen berücksichtigt werden.
Literature	Baltisberger et al., Systematische Botanik. Einheimische Farn- und Samenpflanzen. vdf Hochschulverlag AG an der ETH Zürich (4. Aufl. 2013) Hess et al., Bestimmunsschlüssel zur Flora der Schweiz. Springer, Basel (7. Aufl. 2015) Baltisberger, Conradin, Frey & Rudow, 2016: eBot6. Internetapplikation. Für Studierende frei zugänglich unter http://www.balti.ethz.ch/tiki-index.php?page=eBot6.
Prerequisites / Notice	Für Studierende der Pharmazeutischen Wissenschaften Bsc obligatorisch, für Studierende Biologie Bsc und Umweltnaturwissenschaften Bsc mit Vertiefungen in Ökologie und Evolution (Biologie), Wald und Landschaft oder Umweltbiologie besonders empfohlen.
701-0264-01L	Supplementary Course Systematic Botany Prerequisite: successful participation in 701-0360-00L Systematic Biology: Plants. It is recommended to enroll for both lectures in the same semester.	E-	1 credit	2P	A. Leuchtmann
Abstract	Botanical excursions to Lower Engiadina providing extended systematic-botanical knowledge
Objective	Participants know characters of important plant families and are able to assign species accordingly. They have gained extended knowledge of plant species, particularly of those relevant for the exam, and have received insight into flora and vegetation of the Lower Engiadina valley.
Content	Exkursion in der montanen Stufe bei Klosters am ersten Tag, zwei weitere Exkursionen im Unterengadin. Vertiefung der systematisch-taxonomischen Kenntnisse und Einblick in Flora und Vegetation eines zentralalpinen Trockentals. Gruppenarbeit mit ausgewählten, neuen Pflanzenarten.
Literature	Baltisberger et al., Systematische Botanik. Einheimische Farn- und Samenpflanzen. vdf Hochschulverlag AG an der ETH Zürich (4. Aufl. 2013) Hess et al. 2015. Bestimmunsschlüssel zur Flora der Schweiz. 7. Aufl., Springer, Basel.
Prerequisites / Notice	Der Kurs richtet sich an Studierende Biologie Bsc und Umweltnaturwissenschaften Bsc; auch Studierende Pharmazeutische Wissenschaften Bsc sind willkommen. Der Besuch von "701-0360-00L Systematische Biologie: Pflanzen" wird vorausgesetzt, da der Kurs darauf aufbaut. Diese Lehrveranstaltung ist auf maximal 50 Teilnehmende beschränkt. Schriftliche Anmeldungen erforderlich, die nach Reihenfolge des Eingangs berücksichtigt werden. Kosten für Verpflegung und Unterkunft in Mehrbettzimmern (2 Nächte) müssen von den Teilnehmern übernommen werden (Fr. 80.-).
701-0245-00L	Introduction to Evolutionary Biology	O	2 credits	2V	G. Velicer, S. Wielgoss
Abstract	This course introduces important questions about the evolutionary processes involved in the generation and maintenance of biological diversity across all domains of life and how evolutionary science investigates these questions.
Objective	This course introduces important questions about the evolutionary processes involved in the generation and maintenance of biological diversity across all domains of life and how evolutionary science investigates these questions. The topics covered range from different forms of selection, phylogenetic analysis, population genetics, life history theory, the evolution of sex, social evolution to human evolution. These topics are important for the understanding of a number of evolutionary problems in the basic and applied sciences.
Content	Topics likely to be covered in this course include research methods in evolutionary biology, adaptation, evolution of sex, evolutionary transitions, human evolution, infectious disease evolution, life history evolution, macroevolution, mechanisms of evolution, phylogenetic analysis, population dynamics, population genetics, social evolution, speciation and types of selection.
Literature	Textbook: Evolutionary Analysis Scott Freeman and Jon Herron 5th Edition, English.
Prerequisites / Notice	The exam is based on lecture and textbook.

Cellular and Molecular Biology
Number	Title	Type	ECTS	Hours	Lecturers
551-1174-00L	Systems Biology	O	4 credits	2V + 2U	U. Sauer, K. M. Borgwardt, J. Stelling, N. Zamboni
Abstract	The course teaches computational methods and first hands-on applications by starting from biological problems/phenomena that students in the 4th semester are somewhat familiar with. During the exercises, students will obtain first experience with programming their own analyses/models for data analysis/interpretation.
Objective	We will teach little if any novel biological knowledge or analysis methods, but focus on training the ability of use existing knowledge (for example from enzyme kinetics, regulatory mechanisms or analytical methods) to understand biological problems that arise when considering molecular elements in their context and to translate some of these problems into a form that can be solved by computational methods. Specific goals are: - understand the limitations of intuitive reasoning - obtain a first overview of computational approaches in systems biology - train ability to translate biological problems into computational problems - solve practical problems by programming with MATLAB - make first experiences in computational interpretation of biological data - understand typical abstractions in modeling molecular systems
Content	During the first 7 weeks, the will focus on mechanistic modeling. Starting from simple enzyme kinetics, we will move through the dynamics of small pathways that also include regulation and end with flux balance analysis of a medium size metabolic network. During the second 7 weeks, the focus will shift to the analysis of larger data sets, such as metabolomics and transcriptomics that are often generated in biology. Here we will go through multivariate statistical methods that include clustering and principal component analysis, ending with first methods to learn networks from data.
Lecture notes	Kein Skript
Literature	The course is not taught by a particular book, but two books are suggested for further reading: - Systems Biology (Klipp, Herwig, Kowald, Wierling und Lehrach) Wiley-VCH 2009 - A First Course in Systems Biology (Eberhardt O. Voight) Garland Science 2012
376-0152-00L	Anatomy and Physiology II	O	5 credits	4V	M. Ristow, K. De Bock, M. Kopf, L. Slomianka, C. Spengler
Abstract	Basic knowledge of the anatomy and physiology of the gastrointestinal tract, endocrine organs, urinary system and the reproductive system. Knowlewdge of the basic mechanisms of pathobiology. Study of all human tissues and selected organs by examining slides under the light microscope.
Objective	Foundations of human anatomy and physiology and basics of clinical pathophysiology
Content	Short overview of human anatomy, physiology and general pathology. 3rd semester: Principles of histology and embryology. Anatomy and physiology: nervous system, muscle, sensory organs, circulatory system, respiratory system. 4rd semester: Anatomy and physiology: gastrointestinal tract, endocrine system, metabolism and thermoregulation, integumentary system, blood and immune system, urinary system, circadian rhythm, reproductive system, pregnancy and birth.
Literature	Anatomie: Martini, Timmons, Tallitsch, "Anatomie", Pearson; oder Schiebler, Korf, "Anatomie", Steinkopff / Springer; oder Spornitz, "Anatomie und Physiologie, Lehrbuch und Atlas für Pflege-und Gesundheitsfachberufe", Springer Physiologie: Thews/Mutschler/Vaupel: Anatomie, Physiologie, Pathophysiologie des Menschen, Wissenschaftliche Verlagsgesellschaft, Stuttgart oder Schmidt/Lang/Thews: Physiologie des Menschen, Springer-Verlag, Heidelberg
Prerequisites / Notice	Der Besuch der Anatomie und Physiologie I - Vorlesung ist Voraussetzung, da die Anatomie und Physiologie II - Vorlesung auf dem Wissen der im vorangegangenen Semester gelesenen Anatomie und Physiologie I - Vorlesung aufbaut.
529-0430-00L	Practical Course Physical Chemistry (for Biol./Pharm.Sci.)	O	3 credits	4P	E. C. Meister
Abstract	Practical introduction to important basic experimental methods in physical chemistry. Investigation of qualitative and quantitative relations between physico-chemical quantities of the systems under study.
Objective	The students have to carry out selected experiments in physical chemistry using important measurement methods and devices. The measured data have to be processed, mostly with the aid of computers, and considering error propagation and statistics. Detailed laboratory reports have to be written to each experiment.
Content	Basic physical chemistry experiments covering chemical thermodynamics and kinetics, electrochemistry, viscosity and optical spectroscopy. Computer simulation of physical-chemical phenomena.
Lecture notes	Erich Meister, Grundpraktikum Physikalische Chemie: Theorie und Experimente, 2. Auflage, vdf Hochschul-Verlag an der ETH, Zürich, 2012. Supplementary material to experiments is available.
701-0245-00L	Introduction to Evolutionary Biology	O	2 credits	2V	G. Velicer, S. Wielgoss
Abstract	This course introduces important questions about the evolutionary processes involved in the generation and maintenance of biological diversity across all domains of life and how evolutionary science investigates these questions.
Objective	This course introduces important questions about the evolutionary processes involved in the generation and maintenance of biological diversity across all domains of life and how evolutionary science investigates these questions. The topics covered range from different forms of selection, phylogenetic analysis, population genetics, life history theory, the evolution of sex, social evolution to human evolution. These topics are important for the understanding of a number of evolutionary problems in the basic and applied sciences.
Content	Topics likely to be covered in this course include research methods in evolutionary biology, adaptation, evolution of sex, evolutionary transitions, human evolution, infectious disease evolution, life history evolution, macroevolution, mechanisms of evolution, phylogenetic analysis, population dynamics, population genetics, social evolution, speciation and types of selection.
Literature	Textbook: Evolutionary Analysis Scott Freeman and Jon Herron 5th Edition, English.
Prerequisites / Notice	The exam is based on lecture and textbook.

Biological Chemistry
Number	Title	Type	ECTS	Hours	Lecturers
551-1174-00L	Systems Biology	W	4 credits	2V + 2U	U. Sauer, K. M. Borgwardt, J. Stelling, N. Zamboni
Abstract	The course teaches computational methods and first hands-on applications by starting from biological problems/phenomena that students in the 4th semester are somewhat familiar with. During the exercises, students will obtain first experience with programming their own analyses/models for data analysis/interpretation.
Objective	We will teach little if any novel biological knowledge or analysis methods, but focus on training the ability of use existing knowledge (for example from enzyme kinetics, regulatory mechanisms or analytical methods) to understand biological problems that arise when considering molecular elements in their context and to translate some of these problems into a form that can be solved by computational methods. Specific goals are: - understand the limitations of intuitive reasoning - obtain a first overview of computational approaches in systems biology - train ability to translate biological problems into computational problems - solve practical problems by programming with MATLAB - make first experiences in computational interpretation of biological data - understand typical abstractions in modeling molecular systems
Content	During the first 7 weeks, the will focus on mechanistic modeling. Starting from simple enzyme kinetics, we will move through the dynamics of small pathways that also include regulation and end with flux balance analysis of a medium size metabolic network. During the second 7 weeks, the focus will shift to the analysis of larger data sets, such as metabolomics and transcriptomics that are often generated in biology. Here we will go through multivariate statistical methods that include clustering and principal component analysis, ending with first methods to learn networks from data.
Lecture notes	Kein Skript
Literature	The course is not taught by a particular book, but two books are suggested for further reading: - Systems Biology (Klipp, Herwig, Kowald, Wierling und Lehrach) Wiley-VCH 2009 - A First Course in Systems Biology (Eberhardt O. Voight) Garland Science 2012
529-0222-00L	Organic Chemistry II	O	3 credits	2V + 1U	J. W. Bode, B. Morandi
Abstract	This course builds on the material learned in Organic Chemistry I or Organic Chemistry II for Biology/Pharmacy Students. Topics include advanced concepts and mechanisms of organic reactions and introductions to pericyclic and organometallic reactions. These topics are combined to the planning and execution of multiple step syntheses of complex molecules.
Objective	Goals of this course include the a deeper understanding of basic organic reactions and mechanism as well as advanced and catalytic transformations (for example, Mitsunobu reactions, Corey-Chaykovsky epoxidation, Stetter reactions, etc). Reactive intermediates including carbenes and nitrenes are covered, along with methods for their generation and use in complex molecule synthesis. Frontier molecular orbital theory (FMO) is introduced and used to rationalize pericyclic reactions including Diels Alder reactions, cycloadditions, and rearrangements (Cope, Claisen). The basic concepts and key reactions of catalytic organometallic chemistry, which are key methods in modern organic synthesis, and introduced, with an emphasis on their catalytic cycles and elementrary steps. All of these topics are combined in an overview of strategies for complex molecule synthesis, with specific examples from natural product derived molecules used as medicines.
Content	Oxidation and reduction of organic compounds, redox netural reactions and rearrangments, advanced transformations of functional groups and reaction mechanismes, kinetic and thermodynamic control of organic reactions, carbenes and nitrenes, frontier molecular orbital theory (FMO), cycloadditions and pericyclic reactions, introduction to organometallic chemistry and catalytic cross couplings, introduction to peptide synthesis and protecting groups, retrosynthetic analysis of complex organic molecules, planning and execution of multi-step reaction.
Lecture notes	The lecture notes and additional documents including problem sets are available as PDF files online, without charge. Link: http://www.bode.ethz.ch/education.html
Literature	Clayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012.
529-0430-00L	Practical Course Physical Chemistry (for Biol./Pharm.Sci.)	O	3 credits	4P	E. C. Meister
Abstract	Practical introduction to important basic experimental methods in physical chemistry. Investigation of qualitative and quantitative relations between physico-chemical quantities of the systems under study.
Objective	The students have to carry out selected experiments in physical chemistry using important measurement methods and devices. The measured data have to be processed, mostly with the aid of computers, and considering error propagation and statistics. Detailed laboratory reports have to be written to each experiment.
Content	Basic physical chemistry experiments covering chemical thermodynamics and kinetics, electrochemistry, viscosity and optical spectroscopy. Computer simulation of physical-chemical phenomena.
Lecture notes	Erich Meister, Grundpraktikum Physikalische Chemie: Theorie und Experimente, 2. Auflage, vdf Hochschul-Verlag an der ETH, Zürich, 2012. Supplementary material to experiments is available.
376-0152-00L	Anatomy and Physiology II	W	5 credits	4V	M. Ristow, K. De Bock, M. Kopf, L. Slomianka, C. Spengler
Abstract	Basic knowledge of the anatomy and physiology of the gastrointestinal tract, endocrine organs, urinary system and the reproductive system. Knowlewdge of the basic mechanisms of pathobiology. Study of all human tissues and selected organs by examining slides under the light microscope.
Objective	Foundations of human anatomy and physiology and basics of clinical pathophysiology
Content	Short overview of human anatomy, physiology and general pathology. 3rd semester: Principles of histology and embryology. Anatomy and physiology: nervous system, muscle, sensory organs, circulatory system, respiratory system. 4rd semester: Anatomy and physiology: gastrointestinal tract, endocrine system, metabolism and thermoregulation, integumentary system, blood and immune system, urinary system, circadian rhythm, reproductive system, pregnancy and birth.
Literature	Anatomie: Martini, Timmons, Tallitsch, "Anatomie", Pearson; oder Schiebler, Korf, "Anatomie", Steinkopff / Springer; oder Spornitz, "Anatomie und Physiologie, Lehrbuch und Atlas für Pflege-und Gesundheitsfachberufe", Springer Physiologie: Thews/Mutschler/Vaupel: Anatomie, Physiologie, Pathophysiologie des Menschen, Wissenschaftliche Verlagsgesellschaft, Stuttgart oder Schmidt/Lang/Thews: Physiologie des Menschen, Springer-Verlag, Heidelberg
Prerequisites / Notice	Der Besuch der Anatomie und Physiologie I - Vorlesung ist Voraussetzung, da die Anatomie und Physiologie II - Vorlesung auf dem Wissen der im vorangegangenen Semester gelesenen Anatomie und Physiologie I - Vorlesung aufbaut.

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